Identification of Asthma Phenotypes in the Spanish MEGA Cohort Study Using Cluster Analysis

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Identification of Asthma Phenotypes in the Spanish MEGA Cohort Study Using Cluster Analysis

Matabuena, Marcos (författare): University of Santiago de Compostela

Salgado, Francisco Javier (författare): University of Santiago de Compostela

Nieto-Fontarigo, Juan José (författare): Lund University,Lunds universitet,Respiratorisk immunofarmakologi,Forskargrupper vid Lunds universitet,Respiratory Immunopharmacology,Lund University Research Groups,University of Santiago de Compostela,Health Research Institute of Santiago de Compostela (IDIS)

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Álvarez-Puebla, María J. (författare): University of Navarra

Arismendi, Ebymar (författare): Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),University of Barcelona,Hospital Clínic of Barcelona,CIBER Enfermedades Respiratorias (CIBERES)

Barranco, Pilar (författare): CIBER Enfermedades Respiratorias (CIBERES),University Hospital La Paz

Bobolea, Irina (författare): University of Barcelona,CIBER Enfermedades Respiratorias (CIBERES),Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Hospital Clínic of Barcelona

Caballero, María L. (författare): University Hospital La Paz

Cañas, José Antonio (författare): Hospital Fundación Jiménez Díaz,CIBER Enfermedades Respiratorias (CIBERES)

Cárdaba, Blanca (författare): CIBER Enfermedades Respiratorias (CIBERES)

Cruz, María Jesus (författare): Autonomous University of Barcelona,CIBER Enfermedades Respiratorias (CIBERES),Vall d'Hebron University Hospital

Curto, Elena (författare): Sant Pau Biomedical Research Institute,CIBER Enfermedades Respiratorias (CIBERES),Hospital de Sant Pau,Autonomous University of Barcelona

Domínguez-Ortega, Javier (författare): University Hospital La Paz

Luna, Juan Alberto (författare): University Hospital La Paz

Martínez-Rivera, Carlos (författare): CIBER Enfermedades Respiratorias (CIBERES),Hospital Universitari Germans Trias i Pujol

Mullol, Joaquim (författare): CIBER Enfermedades Respiratorias (CIBERES),Hospital Clínic of Barcelona,Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),University of Barcelona

Muñoz, Xavier (författare): Vall d'Hebron University Hospital,Autonomous University of Barcelona,CIBER Enfermedades Respiratorias (CIBERES)

Rodriguez-Garcia, Javier (författare): CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN)

Olaguibel, José María (författare): CIBER Enfermedades Respiratorias (CIBERES),University of Navarra

Picado, César (författare): CIBER Enfermedades Respiratorias (CIBERES),University of Barcelona,Hospital Clínic of Barcelona,Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)

Plaza, Vicente (författare): Sant Pau Biomedical Research Institute,Hospital de Sant Pau,Autonomous University of Barcelona,CIBER Enfermedades Respiratorias (CIBERES)

Quirce, Santiago (författare): CIBER Enfermedades Respiratorias (CIBERES),University Hospital La Paz

Rial, Manuel J. (författare): University of A Coruña

Romero-Mesones, Christian (författare): Vall d'Hebron University Hospital

Sastre, Beatriz (författare): CIBER Enfermedades Respiratorias (CIBERES),Hospital Fundación Jiménez Díaz

Soto-Retes, Lorena (författare): Sant Pau Biomedical Research Institute,Autonomous University of Barcelona,Hospital de Sant Pau,CIBER Enfermedades Respiratorias (CIBERES)

Valero, Antonio (författare): Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),CIBER Enfermedades Respiratorias (CIBERES),University of Barcelona,Hospital Clínic of Barcelona

Valverde-Monge, Marcela (författare): Hospital Fundación Jiménez Díaz

Del Pozo, Victoria (författare): Hospital Fundación Jiménez Díaz,CIBER Enfermedades Respiratorias (CIBERES),Health Research Institute Jiménez Díaz Foundation

Sastre, Joaquín (författare): Hospital Fundación Jiménez Díaz,CIBER Enfermedades Respiratorias (CIBERES)

González-Barcala, Francisco Javier (författare): Complejo Hospitalario Universitario de Santiago,CIBER Enfermedades Respiratorias (CIBERES),CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN)

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Elsevier BV, 2023
2023
Engelska.
Ingår i: Archivos de Bronconeumologia. - : Elsevier BV. - 0300-2896. ; 59:4, s. 223-231

Relaterad länk:: http://dx.doi.org/10...; visa fler...; https://lup.lub.lu.s...; https://doi.org/10.1...; visa färre...

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Introduction: The definition of asthma phenotypes has not been fully established, neither there are cluster studies showing homogeneous results to solidly establish clear phenotypes. The purpose of this study was to develop a classification algorithm based on unsupervised cluster analysis, identifying clusters that represent clinically relevant asthma phenotypes that may share asthma-related outcomes. Methods: We performed a multicentre prospective cohort study, including adult patients with asthma (N = 512) from the MEGA study (Mechanisms underlying the Genesis and evolution of Asthma). A standardised clinical history was completed for each patient. Cluster analysis was performed using the kernel k-groups algorithm. Results: Four clusters were identified. Cluster 1 (31.5% of subjects) includes adult-onset atopic patients with better lung function, lower BMI, good asthma control, low ICS dose, and few exacerbations. Cluster 2 (23.6%) is made of adolescent-onset atopic asthma patients with normal lung function, but low adherence to treatment (59% well-controlled) and smokers (48%). Cluster 3 (17.1%) includes adult-onset patients, mostly severe non-atopic, with overweight, the worse lung function and asthma control, and receiving combination of treatments. Cluster 4 (26.7%) consists of the elderly-onset patients, mostly female, atopic (64%), with high BMI and normal lung function, prevalence of smokers and comorbidities. Conclusion: We defined four phenotypes of asthma using unsupervised cluster analysis. These clusters are clinically relevant and differ from each other as regards FEV1, age of onset, age, BMI, atopy, asthma severity, exacerbations, control, social class, smoking and nasal polyps.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

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Av lärosätet: Lunds universitet

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Identification of Asthma Phenotypes in the Spanish MEGA Cohort Study Using Cluster Analysis

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