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Identification of A...
Identification of Asthma Phenotypes in the Spanish MEGA Cohort Study Using Cluster Analysis
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- Matabuena, Marcos (author)
- University of Santiago de Compostela
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- Salgado, Francisco Javier (author)
- University of Santiago de Compostela
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- Nieto-Fontarigo, Juan José (author)
- Lund University,Lunds universitet,Respiratorisk immunofarmakologi,Forskargrupper vid Lunds universitet,Respiratory Immunopharmacology,Lund University Research Groups,University of Santiago de Compostela,Health Research Institute of Santiago de Compostela (IDIS)
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- Álvarez-Puebla, María J. (author)
- University of Navarra
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- Arismendi, Ebymar (author)
- University of Barcelona,Hospital Clínic of Barcelona,Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),CIBER Enfermedades Respiratorias (CIBERES)
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- Barranco, Pilar (author)
- CIBER Enfermedades Respiratorias (CIBERES),University Hospital La Paz
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- Bobolea, Irina (author)
- Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Hospital Clínic of Barcelona,University of Barcelona,CIBER Enfermedades Respiratorias (CIBERES)
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- Caballero, María L. (author)
- University Hospital La Paz
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- Cañas, José Antonio (author)
- Hospital Fundación Jiménez Díaz,CIBER Enfermedades Respiratorias (CIBERES)
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- Cárdaba, Blanca (author)
- CIBER Enfermedades Respiratorias (CIBERES)
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- Cruz, María Jesus (author)
- Autonomous University of Barcelona,Vall d'Hebron University Hospital,CIBER Enfermedades Respiratorias (CIBERES)
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- Curto, Elena (author)
- CIBER Enfermedades Respiratorias (CIBERES),Sant Pau Biomedical Research Institute,Autonomous University of Barcelona,Hospital de Sant Pau
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- Domínguez-Ortega, Javier (author)
- University Hospital La Paz
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- Luna, Juan Alberto (author)
- University Hospital La Paz
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- Martínez-Rivera, Carlos (author)
- Hospital Universitari Germans Trias i Pujol,CIBER Enfermedades Respiratorias (CIBERES)
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- Mullol, Joaquim (author)
- University of Barcelona,CIBER Enfermedades Respiratorias (CIBERES),Hospital Clínic of Barcelona,Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)
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- Muñoz, Xavier (author)
- Autonomous University of Barcelona,Vall d'Hebron University Hospital,CIBER Enfermedades Respiratorias (CIBERES)
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- Rodriguez-Garcia, Javier (author)
- CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN)
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- Olaguibel, José María (author)
- CIBER Enfermedades Respiratorias (CIBERES),University of Navarra
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- Picado, César (author)
- University of Barcelona,Hospital Clínic of Barcelona,CIBER Enfermedades Respiratorias (CIBERES),Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)
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- Plaza, Vicente (author)
- CIBER Enfermedades Respiratorias (CIBERES),Sant Pau Biomedical Research Institute,Autonomous University of Barcelona,Hospital de Sant Pau
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- Quirce, Santiago (author)
- University Hospital La Paz,CIBER Enfermedades Respiratorias (CIBERES)
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- Rial, Manuel J. (author)
- University of A Coruña
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- Romero-Mesones, Christian (author)
- Vall d'Hebron University Hospital
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- Sastre, Beatriz (author)
- Hospital Fundación Jiménez Díaz,CIBER Enfermedades Respiratorias (CIBERES)
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- Soto-Retes, Lorena (author)
- Hospital de Sant Pau,Autonomous University of Barcelona,Sant Pau Biomedical Research Institute,CIBER Enfermedades Respiratorias (CIBERES)
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- Valero, Antonio (author)
- University of Barcelona,Hospital Clínic of Barcelona,Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),CIBER Enfermedades Respiratorias (CIBERES)
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- Valverde-Monge, Marcela (author)
- Hospital Fundación Jiménez Díaz
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- Del Pozo, Victoria (author)
- CIBER Enfermedades Respiratorias (CIBERES),Health Research Institute Jiménez Díaz Foundation,Hospital Fundación Jiménez Díaz
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- Sastre, Joaquín (author)
- CIBER Enfermedades Respiratorias (CIBERES),Hospital Fundación Jiménez Díaz
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- González-Barcala, Francisco Javier (author)
- Complejo Hospitalario Universitario de Santiago,CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),CIBER Enfermedades Respiratorias (CIBERES)
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
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In: Archivos de Bronconeumologia. - : Elsevier BV. - 0300-2896. ; 59:4, s. 223-231
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Introduction: The definition of asthma phenotypes has not been fully established, neither there are cluster studies showing homogeneous results to solidly establish clear phenotypes. The purpose of this study was to develop a classification algorithm based on unsupervised cluster analysis, identifying clusters that represent clinically relevant asthma phenotypes that may share asthma-related outcomes. Methods: We performed a multicentre prospective cohort study, including adult patients with asthma (N = 512) from the MEGA study (Mechanisms underlying the Genesis and evolution of Asthma). A standardised clinical history was completed for each patient. Cluster analysis was performed using the kernel k-groups algorithm. Results: Four clusters were identified. Cluster 1 (31.5% of subjects) includes adult-onset atopic patients with better lung function, lower BMI, good asthma control, low ICS dose, and few exacerbations. Cluster 2 (23.6%) is made of adolescent-onset atopic asthma patients with normal lung function, but low adherence to treatment (59% well-controlled) and smokers (48%). Cluster 3 (17.1%) includes adult-onset patients, mostly severe non-atopic, with overweight, the worse lung function and asthma control, and receiving combination of treatments. Cluster 4 (26.7%) consists of the elderly-onset patients, mostly female, atopic (64%), with high BMI and normal lung function, prevalence of smokers and comorbidities. Conclusion: We defined four phenotypes of asthma using unsupervised cluster analysis. These clusters are clinically relevant and differ from each other as regards FEV1, age of onset, age, BMI, atopy, asthma severity, exacerbations, control, social class, smoking and nasal polyps.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Asthma
- Asthma endotypes
- Asthma phenotypes
- Clustering analysis
Publication and Content Type
- art (subject category)
- ref (subject category)
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Matabuena, Marco ...
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Salgado, Francis ...
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Nieto-Fontarigo, ...
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Álvarez-Puebla, ...
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Arismendi, Ebyma ...
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Barranco, Pilar
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Bobolea, Irina
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Caballero, María ...
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Cañas, José Anto ...
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Cárdaba, Blanca
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Cruz, María Jesu ...
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Curto, Elena
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Domínguez-Ortega ...
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Luna, Juan Alber ...
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Martínez-Rivera, ...
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Mullol, Joaquim
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Muñoz, Xavier
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Rodriguez-Garcia ...
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Olaguibel, José ...
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Picado, César
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Plaza, Vicente
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Quirce, Santiago
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Rial, Manuel J.
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Romero-Mesones, ...
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Sastre, Beatriz
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Soto-Retes, Lore ...
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Valero, Antonio
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Valverde-Monge, ...
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Del Pozo, Victor ...
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Sastre, Joaquín
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González-Barcala ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
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Archivos de Bron ...
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Lund University