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WFRF:(Lakhani Sunil R.)
 

Search: WFRF:(Lakhani Sunil R.) > (2016) > Breast cancer genom...

  • Smid, MarcelErasmus University Rotterdam (author)

Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-09-26
  • Springer Science and Business Media LLC,2016

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:941ca49e-9b75-4f4b-b2af-64aa170d33be
  • https://lup.lub.lu.se/record/941ca49e-9b75-4f4b-b2af-64aa170d33beURI
  • https://doi.org/10.1038/ncomms12910DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • A recent comprehensive whole genome analysis of a large breast cancer cohort was used to link known and novel drivers and substitution signatures to the transcriptome of 266 cases. Here, we validate that subtype-specific aberrations show concordant expression changes for, for example, TP53, PIK3CA, PTEN, CCND1 and CDH1. We find that CCND3 expression levels do not correlate with amplification, while increased GATA3 expression in mutant GATA3 cancers suggests GATA3 is an oncogene. In luminal cases the total number of substitutions, irrespective of type, associates with cell cycle gene expression and adverse outcome, whereas the number of mutations of signatures 3 and 13 associates with immune-response specific gene expression, increased numbers of tumour-infiltrating lymphocytes and better outcome. Thus, while earlier reports imply that the sheer number of somatic aberrations could trigger an immune-response, our data suggests that substitutions of a particular type are more effective in doing so than others.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rodríguez-González, F GermánErasmus University Rotterdam (author)
  • Sieuwerts, Anieta MErasmus University Rotterdam (author)
  • Salgado, RobertoUniversité Libre de Bruxelles (ULB) (author)
  • Prager-Van der Smissen, Wendy J CErasmus University Rotterdam (author)
  • Vlugt-Daane, Michelle van derErasmus University Rotterdam (author)
  • van Galen, AnneErasmus University Rotterdam (author)
  • Nik-Zainal, SerenaWellcome Trust Sanger Institute (author)
  • Staaf, JohanLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-jst (author)
  • Brinkman, Arie BRadboud University Nijmegen (author)
  • van de Vijver, Marc JAcademic Medical Center of University of Amsterdam (AMC) (author)
  • Richardson, Andrea LBrigham and Women's Hospital / Harvard Medical School (author)
  • Fatima, AquilaErasmus University Rotterdam (author)
  • Berentsen, KimRadboud University Nijmegen (author)
  • Butler, AdamWellcome Trust Sanger Institute (author)
  • Martin, SanchaWellcome Trust Sanger Institute (author)
  • Davies, Helen RWellcome Trust Sanger Institute (author)
  • Debets, RenoErasmus University Rotterdam (author)
  • Gelder, Marion E Meijer-VanErasmus University Rotterdam (author)
  • van Deurzen, Carolien H MErasmus University Rotterdam (author)
  • MacGrogan, GaëtanInstitut Bergoníe (author)
  • Van den Eynden, Gert G G MUniversity of Antwerp (author)
  • Purdie, ColinNinewells Hospital and Medical School (author)
  • Thompson, Alastair MNinewells Hospital and Medical School (author)
  • Caldas, CarlosUniversity of Cambridge (author)
  • Span, Paul NRadboud University Nijmegen (author)
  • Simpson, Peter TUniversity of Queensland (author)
  • Lakhani, Sunil RUniversity of Queensland (author)
  • Van Laere, StevenUniversity of Antwerp (author)
  • Desmedt, ChristineUniversité Libre de Bruxelles (ULB) (author)
  • Ringnér, MarkusLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)thep-mri (author)
  • Tommasi, StefaniaIstituto Tumori 'Giovanni Paolo II' (author)
  • Eyford, JorunnUniversity of Iceland (author)
  • Broeks, AnnegienNetherlands Cancer Institute (author)
  • Vincent-Salomon, AnneCurie Institute, Paris (author)
  • Futreal, P AndrewUniversity of Texas (author)
  • Knappskog, StianUniversity of Bergen (author)
  • King, TariMemorial Sloan-Kettering Cancer Center (author)
  • Thomas, GillesCentre Léon Bérard (author)
  • Viari, AlainCentre Léon Bérard (author)
  • Langerød, AnitaOslo university hospital (author)
  • Børresen-Dale, Anne-LiseOslo university hospital (author)
  • Birney, EwanEuropean Bioinformatics Institute (author)
  • Stunnenberg, Hendrik GRadboud University Nijmegen (author)
  • Stratton, MikeWellcome Trust Sanger Institute (author)
  • Foekens, John AErasmus University Rotterdam (author)
  • Martens, John W MErasmus University Rotterdam (author)
  • Erasmus University RotterdamUniversité Libre de Bruxelles (ULB) (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Science and Business Media LLC72041-1723

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