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The Mitochondrial D...
The Mitochondrial DNA (mtDNA)-Associated Protein SWIB5 Influences mtDNA Architecture and Homologous Recombination
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- Blomme, Jonas (author)
- Ghent University
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- Van Aken, Olivier (author)
- Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science,University of Western Australia, Crawley
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- Van Leene, Jelle (author)
- Ghent University
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- Jégu, Teddy (author)
- University of Paris-Saclay
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- De Rycke, Riet Maria (author)
- Ghent University
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- De Bruyne, Michiel (author)
- Ghent University
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- Vercruysse, Jasmien (author)
- Ghent University
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- Nolf, Jonah (author)
- Ghent University
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- Van Daele, Twiggy (author)
- Ghent University
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- De Milde, Liesbeth (author)
- Ghent University
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- Vermeersch, Mattias (author)
- Ghent University
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- Colas des Francs-Small, Catherine (author)
- University of Western Australia, Crawley
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- De Jaeger, Geert (author)
- Ghent University
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- Benhamed, Moussa (author)
- University of Paris-Saclay
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- Millar, A. Harvey (author)
- University of Western Australia, Crawley
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- Inzé, Dirk (author)
- Ghent University
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- Gonzalez, Nathalie (author)
- Flanders Interuniversity Institute for Biotechnology,Ghent University
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(creator_code:org_t)
- 2017-04-18
- 2017
- English 20 s.
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In: Plant Cell. - : Oxford University Press (OUP). - 1040-4651 .- 1532-298X. ; 29:5, s. 1137-1156
- Related links:
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http://dx.doi.org/10...
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http://www.plantcell...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In addition to the nucleus, mitochondria and chloroplasts in plant cells also contain genomes. Efficient DNA repair pathways are crucial in these organelles to fix damage resulting from endogenous and exogenous factors. Plant organellar genomes are complex compared to their animal counterparts and although several plant-specific mediators of organelle DNA repair have been reported, many regulators remain to be identified. Here, we show that a mitochondrial SWI/SNF (nucleosome remodeling) complex B protein, SWIB5, is capable of associating with mitochondrial DNA (mtDNA) in Arabidopsis thaliana. Gain- and loss-of-function mutants provided evidence for a role of SWIB5 in influencing mtDNA architecture and homologous recombination at specific intermediate-sized repeats both under normal and genotoxic conditions. SWIB5 interacts with other mitochondrial SWIB proteins. Gene expression and mutant phenotypic analysis of SWIB5 and SWIB family members suggests a link between organellar genome maintenance and cell proliferation. Taken together, our work presents a protein family that influences mtDNA architecture and homologous recombination in plants and suggests a link between organelle functioning and plant development.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
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- art (subject category)
- ref (subject category)
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Plant Cell
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- By the author/editor
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Blomme, Jonas
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Van Aken, Olivie ...
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Van Leene, Jelle
-
Jégu, Teddy
-
De Rycke, Riet M ...
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De Bruyne, Michi ...
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show more...
-
Vercruysse, Jasm ...
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Nolf, Jonah
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Van Daele, Twigg ...
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De Milde, Liesbe ...
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Vermeersch, Matt ...
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Colas des Francs ...
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De Jaeger, Geert
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Benhamed, Moussa
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Millar, A. Harve ...
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Inzé, Dirk
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Gonzalez, Nathal ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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Plant Cell
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Lund University