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Gamma-glutamyltrans...
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Kozakova, MichaelaUniversity of Pisa
(författare)
Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-04-29
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Springer Science and Business Media LLC,2020
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:94447c57-05f9-4481-b9f7-891fe6bd79c8
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https://lup.lub.lu.se/record/94447c57-05f9-4481-b9f7-891fe6bd79c8URI
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https://doi.org/10.1038/s41371-020-0337-1DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Plasma gamma-glutamyltransferase (GGT) was suggested to reflect the level of systemic oxidative stress. Oxidative stress induces changes in arterial structure and function and contributes to the development of hypertension. Therefore, GGT may be associated with arterial remodeling and blood pressure (BP) increment, even in absence of disease. To test this hypothesis, we evaluated, in 825 healthy subjects at low cardiometabolic risk, the associations of plasma GGT with carotid artery intima-media thickness (IMT), luminal diameter and prehypertension; in 154 subjects was evaluated also the association with aortic stiffness (cfPWV). Associations were controlled for insulin sensitivity, C-reactive protein, and life-style habits. In the main population, BP was remeasured after 3 years. Carotid diameter and cfPWV, but not IMT, were directly and independently related to plasma GGT. Subjects with prehypertension (N = 330) had higher GGT as compared with subjects with normal BP (22 [14] vs 17 [11] IU/L; adjusted P = 0.001), and within prehypertensive subjects, those who developed hypertension during 3 years had higher GGT than those without incident hypertension (27 [16] vs 21 [14] IU/L; adjusted P < 0.05). Within subjects with arterial stiffness measurement, those with prehypertension (N = 79) had higher both GGT and arterial stiffness (25 [14] vs 16 [20] IU/L and 9.11 ± 1.24 vs 7.90 ± 0.94 m/s; adjusted P < 0.01 and <0.05). In the view of previous evidence linking plasma GGT concentration to the level of systemic oxidative stress, our findings suggest a role of oxidative stress in subclinical arterial damage and in prehypertension, even in healthy subjects free of cardiometabolic risk. Arterial organ damage may represent the link between GGT and hypertension.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Gastaldelli, AmaliaCNR Institute of Clinical Physiology (IFC-CNR)
(författare)
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Morizzo, CarmelaUniversity of Pisa
(författare)
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Højlund, KurtUniversity of Southern Denmark,Odense University Hospital
(författare)
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Nilsson, Peter MLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-pni
(författare)
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Ferrannini, EleUniversity of Pisa
(författare)
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Palombo, CarloUniversity of Pisa
(författare)
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Nilssone, P.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-pni
(creator_code:cre_t)
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Persson, MargarethaLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-mpe
(creator_code:cre_t)
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Östling, GerdLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-gos
(creator_code:cre_t)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-ome
(creator_code:cre_t)
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Burri, PhilippeLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-pbu
(creator_code:cre_t)
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University of PisaCNR Institute of Clinical Physiology (IFC-CNR)
(creator_code:org_t)
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RISC Investigators
Sammanhörande titlar
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Ingår i:Journal of Human Hypertension: Springer Science and Business Media LLC1476-55270950-9240
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Kozakova, Michae ...
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Gastaldelli, Ama ...
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Morizzo, Carmela
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Højlund, Kurt
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Nilsson, Peter M
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Ferrannini, Ele
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visa fler...
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Palombo, Carlo
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Nilssone, P.
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Persson, Margare ...
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Östling, Gerd
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Melander, Olle
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Burri, Philippe
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Kardiologi
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Journal of Human ...
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Lunds universitet