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Hård af Segerstad, Elin M.Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
(författare)
Associations of dietary patterns between age 9 and 24 months with risk of celiac disease autoimmunity and celiac disease among children at increased risk
- Artikel/kapitelEngelska2023
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LIBRIS-ID:oai:lup.lub.lu.se:9445a2e4-67fc-4ab3-85e1-25222d26549e
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https://lup.lub.lu.se/record/9445a2e4-67fc-4ab3-85e1-25222d26549eURI
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https://doi.org/10.1016/j.ajcnut.2023.08.009DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Background: Higher gluten intake in childhood is associated with increased incidence of celiac disease autoimmunity (CDA) and celiac disease. It remains to be studied whether different dietary patterns independent of gluten intake contribute to the incidence. Objectives: This study aimed to explore associations of dietary patterns by age 2 y with risk of CDA and celiac disease in genetically susceptible children. Methods: Data was used from 6726 participants at genetic risk of type 1 diabetes and celiac disease enrolled in the observational cohort, The Environmental Determinants of Diabetes in the Young (TEDDY) study. Children were annually screened for tissue transglutaminase autoantibodies (tTGAs) from age 2 y. Principal component analysis extracted dietary patterns, based on intake of 27 food groups assessed by 3-d food records at age 9 to 24 mo. The primary outcome was CDA (i.e., persistently tTGA-positive in at least 2 consecutive samples), and the secondary outcome was celiac disease. During follow-up to mean age 11.0 (standard deviation 3.6) y, 1296 (19.3%) children developed CDA, and 529 (7.9%) were diagnosed with celiac disease. Associations of adherence to dietary patterns (per 5-unit increase) with the study outcomes were estimated by Cox regression models adjusted for risk factors including gluten intake. Results: At age 9 mo, a dietary pattern higher in the food groups vegetable fats and milk was associated with reduced risk of CDA (hazard ratio [HR]: 0.88; 95% confidence interval [CI]: 0.79, 0.98; P = 0.02). At 24 mo, a dietary pattern higher in the food groups wheat, vegetable fats, and juices, and lower in milk, meat, and oats at age 24 mo was associated with increased risk of CDA (HR: 1.18; 95% CI: 1.05, 1.33; P < 0.001) and celiac disease (HR: 1.24; 95% CI: 1.03, 1.50; P = 0.03). Conclusions: Dietary patterns in early childhood are associated with risk of CDA and celiac disease in genetically predisposed children, independent of gluten intake.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mramba, Lazarus K.University of South Florida
(författare)
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Liu, XiangUniversity of South Florida
(författare)
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Uusitalo, UllaUniversity of South Florida
(författare)
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Yang, JiminUniversity of South Florida
(författare)
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Norris, JillColorado School of Public Health
(författare)
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Virtanen, Suvi M.Tampere University Hospital,University of Tampere,Finnish National Institute for Health and Welfare
(författare)
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Liu, EdwinThe Children's Hospital, Aurora
(författare)
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Kurppa, KalleTampere University Hospital,University of Tampere
(författare)
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Koletzko, SibylleUniversity Hospital Munich,University of Warmia and Mazury
(författare)
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Ziegler, Annette G.Helmholtz Zentrum München,Klinikum rechts der Isar
(författare)
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Toppari, JormaTurku University Hospital,University of Turku
(författare)
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Rewers, MarianBarbara Davis Center for Childhood Diabetes
(författare)
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Akolkar, BeenaNational Institute of Diabetes and Digestive and Kidney Diseases
(författare)
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Krischer, Jeffrey P.University of South Florida
(författare)
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Aronsson, Carin AndrénLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)smi-can
(författare)
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Agardh, DanielLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)med-dia
(författare)
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Celiaki och diabetesForskargrupper vid Lunds universitet
(creator_code:org_t)
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TEDDY Study Group
Sammanhörande titlar
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Ingår i:American Journal of Clinical Nutrition118:6, s. 1099-11050002-9165
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Hård af Segersta ...
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Mramba, Lazarus ...
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Liu, Xiang
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Uusitalo, Ulla
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Norris, Jill
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Virtanen, Suvi M ...
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Liu, Edwin
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Kurppa, Kalle
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Toppari, Jorma
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Rewers, Marian
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Agardh, Daniel
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