Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes

Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. Results & conclusion: cg19888088 (cross-ancestry) in EBF3, cg01952260 (Europeans) and cg07077240 (South Asians) in HERC3 were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants in CASC15. The findings were not replicated and were not significant in cord blood.

Page, Christian MNorwegian Institute of Public Health (författare)
Joubert, Bonnie RNational Institute of Environmental Health Sciences (författare)
London, Stephanie JNational Institute of Environmental Health Sciences (författare)
Lee-Ødegård, SindreUniversity of Oslo (författare)
Opsahl, Julia OUniversity of Oslo (författare)
Sletner, LineAkershus University Hospital (författare)
Jenum, Anne KUniversity of Oslo (författare)
Qvigstad, ElisabethOslo university hospital (författare)
Prasad, Rashmi BLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki(Swepub:lu)med-rpa (författare)
Moen, Gunn-HelenUniversity of Queensland (författare)
Birkeland, Kåre IUniversity of Oslo (författare)
Sommer, ChristineOslo university hospital (författare)
Oslo university hospitalNorwegian Institute of Public Health (creator_code:org_t)

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