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Sökning: WFRF:(Olsen Markus Harboe) > (2022) > Protocol for an ind...

  • Skrifvars, Markus B.Helsinki University Central Hospital (författare)

Protocol for an individual patient data meta-analysis on blood pressure targets after cardiac arrest

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-06-09
  • Wiley,2022

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:94c5530d-275e-44f0-aa34-24a49d54b223
  • https://lup.lub.lu.se/record/94c5530d-275e-44f0-aa34-24a49d54b223URI
  • https://doi.org/10.1111/aas.14090DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background: Hypotension is common after cardiac arrest (CA), and current guidelines recommend using vasopressors to target mean arterial blood pressure (MAP) higher than 65 mmHg. Pilot trials have compared higher and lower MAP targets. We will review the evidence on whether higher MAP improves outcome after cardiac arrest. Methods: This systematic review and meta-analysis will be conducted based on a systematic search of relevant major medical databases from their inception onwards, including MEDLINE, Embase and the Cochrane Central Register of Controlled Trials (CENTRAL), as well as clinical trial registries. We will identify randomised controlled trials published in the English language that compare targeting a MAP higher than 65–70 mmHg in CA patients using vasopressors, inotropes and intravenous fluids. The data extraction will be performed separately by two authors (a third author will be involved in case of disagreement), followed by a bias assessment with the Cochrane Risk of Bias tool using an eight-step procedure for assessing if thresholds for clinical significance are crossed. The outcomes will be all-cause mortality, functional long-term outcomes and serious adverse events. We will contact the authors of the identified trials to request individual anonymised patient data to enable individual patient data meta-analysis, aggregate data meta-analyses, trial sequential analyses and multivariable regression, controlling for baseline characteristics. The certainty of the evidence will be assessed by the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. We will register this systematic review with Prospero and aim to redo it when larger trials are published in the near future. Conclusions: This protocol defines the performance of a systematic review on whether a higher MAP after cardiac arrest improves patient outcome. Repeating this systematic review including more data likely will allow for more certainty regarding the effect of the intervention and possible sub-groups differences.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ameloot, KoenUniversity Hospitals Leuven,Hospital Oost-Limburg,Hasselt University (författare)
  • Grand, JohannesCopenhagen University Hospital (författare)
  • Reinikainen, MattiUniversity of Eastern Finland (författare)
  • Hästbacka, JohannaHelsinki University Central Hospital (författare)
  • Niemelä, VilleHelsinki University Central Hospital (författare)
  • Hassager, ChristianCopenhagen University Hospital (författare)
  • Kjaergaard, JesperCopenhagen University Hospital (författare)
  • Åneman, AndersMacquarie University, Sydney,University of New South Wales,South Western Sydney Local Health District (författare)
  • Tiainen, MarjaanaHelsinki University Central Hospital (författare)
  • Nielsen, NiklasLund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Kliniska Vetenskaper, Helsingborg,Institutionen för kliniska vetenskaper, Lund,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Sciences, Helsingborg,Department of Clinical Sciences, Lund,Center for cardiac arrest,Lund University Research Groups,Helsingborg Hospital(Swepub:lu)med-nni (författare)
  • Ullen, SusannSkåne University Hospital,Clinical Studies Sweden-Forum South(Swepub:lu)su7040ul (författare)
  • Dankiewicz, JosefLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-jfd (författare)
  • Olsen, Markus HarboeCopenhagen University Hospital (författare)
  • Jørgensen, Caroline KampCopenhagen University Hospital (författare)
  • Saxena, ManojUniversity of New South Wales (författare)
  • Jakobsen, Janus C.Copenhagen University Hospital,University of Southern Denmark (författare)
  • Helsinki University Central HospitalUniversity Hospitals Leuven (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Acta Anaesthesiologica Scandinavica: Wiley66:7, s. 890-8970001-51721399-6576

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