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  • Ruifrok, Anneloes EAmsterdam UMC - Vrije Universiteit Amsterdam,Academic Medical Center of University of Amsterdam (AMC) (author)

Study protocol : Differential effects of diet and physical activity based interventions in pregnancy on maternal and fetal outcomes: Individual patient data (IPD) meta-analysis and health economic evaluation

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-11-04
  • Springer Science and Business Media LLC,2014

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:94ca3163-55ff-4682-8577-19627bdff628
  • https://lup.lub.lu.se/record/94ca3163-55ff-4682-8577-19627bdff628URI
  • https://doi.org/10.1186/2046-4053-3-131DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • BackgroundPregnant women who gain excess weight are at risk of complications during pregnancy and in the long term. Interventions based on diet and physical activity minimise gestational weight gain with varied effect on clinical outcomes. The effect of interventions on varied groups of women based on body mass index, age, ethnicity, socioeconomic status, parity, and underlying medical conditions is not clear. Our individual patient data (IPD) meta-analysis of randomised trials will assess the differential effect of diet- and physical activity-based interventions on maternal weight gain and pregnancy outcomes in clinically relevant subgroups of women.Methods/designRandomised trials on diet and physical activity in pregnancy will be identified by searching the following databases: MEDLINE, EMBASE, BIOSIS, LILACS, Pascal, Science Citation Index, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects, and Health Technology Assessment Database. Primary researchers of the identified trials are invited to join the International Weight Management in Pregnancy Collaborative Network and share their individual patient data. We will reanalyse each study separately and confirm the findings with the original authors. Then, for each intervention type and outcome, we will perform as appropriate either a one-step or a two-step IPD meta-analysis to obtain summary estimates of effects and 95% confidence intervals, for all women combined and for each subgroup of interest. The primary outcomes are gestational weight gain and composite adverse maternal and fetal outcomes. The difference in effects between subgroups will be estimated and between-study heterogeneity suitably quantified and explored. The potential for publication bias and availability bias in the IPD obtained will be investigated. We will conduct a model-based economic evaluation to assess the cost effectiveness of the interventions to manage weight gain in pregnancy and undertake a value of information analysis to inform future research.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rogozinska, EwelinaQueen Mary University (author)
  • van Poppel, Mireille N MAmsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Rayanagoudar, GirishQueen Mary University (author)
  • Kerry, SallyQueen Mary University (author)
  • de Groot, Christianne J MAmsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Yeo, Seon AeUniversity of North Carolina (author)
  • Molyneaux, EmmaKing's College London (author)
  • Barakat Carballo, RubenTechnical University of Madrid (author)
  • Perales, MariaTechnical University of Madrid (author)
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  • Cecatti, Jose GUniversity of Campinas (author)
  • Surita, FernandaUniversity of Campinas (author)
  • Dodd, JodieUniversity of Adelaide (author)
  • Owens, JulieUniversity of Adelaide (author)
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  • Petrella, ElisabettaUniversity of Modena and Reggio Emilia (author)
  • Phelan, SuzanneCalifornia Polytechnic State University (author)
  • Scudeller, Tânia TEscola Paulista de Medicina (author)
  • Rauh, KathrinCompetence Centre for Nutrition (KErn),Technical University of Munich (author)
  • Hauner, HansTechnical University of Munich (author)
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  • Salvesen, Kjell ÅsmundLund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-ks4 (author)
  • Vinter, ChristinaUniversity of Southern Denmark (author)
  • Vitolo, MarciaFederal University of Health Sciences of Porto Alegre (author)
  • Astrup, ArneUniversity of Copenhagen (author)
  • Geiker, Nina Rica WiumHerlev Hospital (author)
  • McAuliffe, FionnualaUniversity College Dublin (author)
  • Poston, LucillaGuy's and St Thomas' NHS Foundation Trust (author)
  • Roberts, TracyUniversity of Birmingham (author)
  • Riley, Richard DUniversity of Birmingham (author)
  • Coomarasamy, ArriUniversity of Birmingham (author)
  • Khan, Khalid S.Queen Mary University (author)
  • Mol, Ben-WillemUniversity of Adelaide (author)
  • Thangaratinam, ShakilaQueen Mary University (author)
  • Amsterdam UMC - Vrije Universiteit AmsterdamAcademic Medical Center of University of Amsterdam (AMC) (creator_code:org_t)

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  • In:Systematic Reviews: Springer Science and Business Media LLC32046-4053

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