Contribution of Established Stroke Risk Factors to the Burden of Stroke in Young Adults

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MARC

Aigner, AnnetteUniversity Medical Center Hamburg-Eppendorf (author)

Contribution of Established Stroke Risk Factors to the Burden of Stroke in Young Adults

Article/chapterEnglish2017

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2017
8 s.

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LIBRIS-ID:oai:lup.lub.lu.se:953bdd83-d330-4c32-836a-62f15728f82c
https://lup.lub.lu.se/record/953bdd83-d330-4c32-836a-62f15728f82cURI
https://doi.org/10.1161/STROKEAHA.117.016599DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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Background and Purpose - As stroke in young adults is assumed to have different etiologies and risk factors than in older populations, the aim of this study was to examine the contribution of established potentially modifiable cardiovascular risk factors to the burden of stroke in young adults. Methods - A German nationwide case-control study based on patients enrolled in the SIFAP1 study (Stroke In Young Fabry Patients) 2007 to 2010 and controls from the population-based GEDA study (German Health Update) 2009 to 2010 was performed. Cases were 2125 consecutive patients aged 18 to 55 years with acute first-ever stroke from 26 clinical stroke centers; controls (age- and sex-matched, n=8500, without previous stroke) were from a nationwide community sample. Adjusted population-attributable risks of 8 risk factors (hypertension, hyperlipidemia, diabetes mellitus, coronary heart disease, smoking, heavy episodic alcohol consumption, low physical activity, and obesity) and their combinations for all stroke, ischemic stroke, and primary intracerebral hemorrhage were calculated. Results - Low physical activity and hypertension were the most important risk factors, accounting for 59.7% (95% confidence interval, 56.3-63.2) and 27.1% (95% confidence interval, 23.6-30.6) of all strokes, respectively. All 8 risk factors combined explained 78.9% (95% confidence interval, 76.3-81.4) of all strokes. Population-attributable risks of all risk factors were similar for all ischemic stroke subtypes. Population-attributable risks of most risk factors were higher in older age groups and in men. Conclusions - Modifiable risk factors previously established in older populations also account for a large part of stroke in younger adults, with 4 risk factors explaining almost 80% of stroke risk.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
case-control study
population-attributable risk
risk factors
stroke
young adults

Added entries (persons, corporate bodies, meetings, titles ...)

Grittner, UlrikeCharité - University Medicine Berlin (author)
Rolfs, ArndtUniversity of Rostock (author)
Norrving, BoLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Stroke policy och kvalitetsregisterforskning,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Stroke policy and quality register research(Swepub:lu)neur-bno (author)
Siegerink, BobRobert Koch Institut (author)
Busch, Markus A.Robert Koch Institut (author)
University Medical Center Hamburg-EppendorfCharité - University Medicine Berlin (creator_code:org_t)

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In:Stroke48:7, s. 1744-17510039-2499

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By the author/editor: Aigner, Annette; Grittner, Ulrike; Rolfs, Arndt; Norrving, Bo; Siegerink, Bob; Busch, Markus A.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

Articles in the publication: Stroke

By the university: Lund University

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