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Comparison of histo...
Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories
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- Wuestefeld, Anika (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Baumeister, Hannah (author)
- German Center for Neurodegenerative Diseases (DZNE) Magdeburg
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- Adams, Jenna N (author)
- University of California, Irvine
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- de Flores, Robin (author)
- University of Caen Normandy
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- Hodgetts, Carl (author)
- University of London
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- Mazloum-Farzaghi, Negar (author)
- University of Toronto
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Olsen, Rosanna K (author)
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- Puliyadi, Vyash (author)
- Johns Hopkins University
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- Tran, Tammy T (author)
- Stanford University
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Bakker, Arnold (author)
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- Canada, Kelsey L (author)
- Wayne State University
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- Dalton, Marshall A (author)
- University of Sydney
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Daugherty, Ana M (author)
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- Joie, Renaud La (author)
- University of California, San Francisco
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Wang, Lei (author)
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Bedard, Madigan (author)
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Buendia, Esther (author)
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Denning, Amanda (author)
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Irwin, David J (author)
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Ittyerah, Ranjit (author)
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Lee, Edward B (author)
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Lim, Sydney (author)
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de Onzoño Martin, Maria Mercedes Iñiguez (author)
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Lopez, Monica Munoz (author)
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Schuck, Theresa (author)
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Trotman, Winifred (author)
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Vela, Alicia (author)
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Yushkevich, Paul (author)
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Amunts, Katrin (author)
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Augustinack, Jean C (author)
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Ding, Song-Lin (author)
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Insausti, Ricardo (author)
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Kedo, Olga (author)
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- Berron, David (author)
- German Center for Neurodegenerative Diseases (DZNE) Magdeburg
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- Wisse, Laura E M (author)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,LU Profile Area: Proactive Ageing,Lund University Profile areas
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(creator_code:org_t)
- 2023
- English.
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- The medial temporal lobe (MTL) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies such as Alzheimer's disease neurofibrillary tau tangles. The MTL cortex is composed of several subregions which differ in their functional and cytoarchitectonic features. As neuroanatomical schools rely on different cytoarchitectonic definitions of these subregions, it is unclear to what extent their delineations of MTL cortex subregions overlap. Here, we provide an overview of cytoarchitectonic definitions of the cortices that make up the parahippocampal gyrus (entorhinal and parahippocampal cortices) and the adjacent Brodmann areas (BA) 35 and 36, as provided by four neuroanatomists from different laboratories, aiming to identify the rationale for overlapping and diverging delineations. Nissl-stained series were acquired from the temporal lobes of three human specimens (two right and one left hemisphere). Slices (50 µm thick) were prepared perpendicular to the long axis of the hippocampus spanning the entire longitudinal extent of the MTL cortex. Four neuroanatomists annotated MTL cortex subregions on digitized (20X resolution) slices with 5 mm spacing. Parcellations, terminology, and border placement were compared among neuroanatomists. Cytoarchitectonic features of each subregion are described in detail. Qualitative analysis of the annotations showed higher agreement in the definitions of the entorhinal cortex and BA35, while definitions of BA36 and the parahippocampal cortex exhibited less overlap among neuroanatomists. The degree of overlap of cytoarchitectonic definitions was partially reflected in the neuroanatomists' agreement on the respective delineations. Lower agreement in annotations was observed in transitional zones between structures where seminal cytoarchitectonic features are expressed more gradually. The results highlight that definitions and parcellations of the MTL cortex differ among neuroanatomical schools and thereby increase understanding of why these differences may arise. This work sets a crucial foundation to further advance anatomically-informed human neuroimaging research on the MTL cortex.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ovr (subject category)
- vet (subject category)
To the university's database
- By the author/editor
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Wuestefeld, Anik ...
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Baumeister, Hann ...
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Adams, Jenna N
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de Flores, Robin
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Hodgetts, Carl
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Mazloum-Farzaghi ...
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show more...
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Olsen, Rosanna K
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Puliyadi, Vyash
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Tran, Tammy T
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Bakker, Arnold
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Canada, Kelsey L
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Dalton, Marshall ...
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Daugherty, Ana M
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Joie, Renaud La
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Wang, Lei
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Bedard, Madigan
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Buendia, Esther
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Denning, Amanda
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Irwin, David J
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Ittyerah, Ranjit
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Lee, Edward B
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Lim, Sydney
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de Onzoño Martin ...
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Lopez, Monica Mu ...
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Schuck, Theresa
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Trotman, Winifre ...
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Vela, Alicia
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Yushkevich, Paul
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Amunts, Katrin
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Augustinack, Jea ...
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Ding, Song-Lin
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Insausti, Ricard ...
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Kedo, Olga
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Berron, David
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Wisse, Laura E M
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- By the university
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Lund University