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  • Stockhammer, PaulRuhrlandklinik (författare)

Krebs von den Lungen 6 (KL-6) is a novel diagnostic and prognostic biomarker in pleural mesothelioma

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:c365e068-ffe7-4da6-84bb-f3ba3e729621
  • https://lup.lub.lu.se/record/c365e068-ffe7-4da6-84bb-f3ba3e729621URI
  • https://doi.org/10.1016/j.lungcan.2023.107360DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Objectives: Pleural mesothelioma (PM) is a rare disease with dismal outcome. Systemic treatment options include chemotherapy and immunotherapy, but biomarkers for treatment personalization are missing. The only FDA-approved diagnostic biomarker is the soluble mesothelin-related protein (SMRP). Krebs von den Lungen-6 (KL-6) is a human mucin 1 (MUC1) glycoprotein, which has shown diagnostic and prognostic value as a biomarker in other malignancies. The present study investigated whether KL-6 can serve as a diagnostic and/or prognostic biomarker in PM. Materials and methods: Using a fully-automated chemiluminescence enzyme immunoassay (CLEIA) for KL-6 and SMRP, pleural effusion samples from 87 consecutive patients with PM and 25 patients with non-malignant pleural disorders were studied. In addition, KL-6 and SMRP levels were determined in corresponding patient sera, and in an independent validation cohort (n = 122). MUC1 mRNA and protein expression, and KL-6 levels in cell line supernatants were investigated in PM primary cell lines in vitro. Results: PM patients had significantly higher KL-6 levels in pleural effusion than non-malignant controls (AUC 0.78, p < 0.0001). Among PM patients, levels were highest in those with epithelioid or biphasic histologies. There was a strong positive correlation between pleural effusion levels of KL-6 and SMRP (p < 0.0001). KL-6 levels in sera similarly associated with diagnosis of PM, however, to a lesser extent (AUC 0.71, p = 0.008). PM patients with high pleural effusion KL-6 levels (≥303 IU/mL) had significantly better overall survival (OS) compared to those with low KL-6 levels (HR 0.51, p = 0.004). Congruently, high tumor cell MUC1 mRNA expression in primary cell lines associated with prolonged corresponding patient OS (HR 0.35, p = 0.004). These findings were confirmed in an independent validation cohort. Conclusion: This is the first study demonstrating KL-6 as a potential novel liquid-based diagnostic and prognostic biomarker in PM.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Baumeister, HannahRuhrlandklinik (författare)
  • Ploenes, TillRuhrlandklinik (författare)
  • Bonella, FrancescoRuhrlandklinik (författare)
  • Theegarten, DirkUniversity Hospital Essen (författare)
  • Dome, BalazsLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna(Swepub:lu)ba1464do (författare)
  • Pirker, ChristineMedical University of Vienna (författare)
  • Berger, WalterMedical University of Vienna (författare)
  • Hegedüs, LucaRuhrlandklinik (författare)
  • Baranyi, MarcellSemmelweis University (författare)
  • Schuler, MartinUniversity Hospital Essen (författare)
  • Deshayes, SophieUniversity of Nantes (författare)
  • Bölükbas, ServetRuhrlandklinik (författare)
  • Aigner, ClemensUniversity Hospital Essen,Ruhrlandklinik (författare)
  • Blanquart, ChristopheUniversity of Nantes (författare)
  • Hegedüs, BalazsRuhrlandklinik (författare)
  • RuhrlandklinikUniversity Hospital Essen (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Lung Cancer1850169-5002

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