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The decorin sequenc...
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Kalamajski, SebastianLund University,Lunds universitet,Åke Oldbergs forskargrupp,Forskargrupper vid Lunds universitet,Åke Oldberg´s group,Lund University Research Groups
(author)
The decorin sequence SYIRIADTNIT binds collagen type I.
- Article/chapterEnglish2007
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Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:95618b0d-40c1-4d33-9e6c-48f82faba9cb
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https://lup.lub.lu.se/record/167721URI
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https://doi.org/10.1074/jbc.M700073200DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Decorin belongs to the small leucine-rich repeat proteoglycan family, interacts with fibrillar collagens, and regulates the assembly, structure, and biomechanical properties of connective tissues. The decorin-collagen type I-binding region is located in leucine-rich repeats 5–6. Site-directed mutagenesis of this 54-residue-long collagen-binding sequence identifies Arg-207 and Asp-210 in leucine-rich repeat 6 as crucial for the binding to collagen. The synthetic peptide SYIRIADTNIT, which includes Arg-207 and Asp-210, inhibits the binding of full-length recombinant decorin to collagen in vitro. These collagen-binding amino acids are exposed on the exterior of the beta-sheet-loop structure of the leucine-rich repeat. This resembles the location of interacting residues in other leucine-rich repeat proteins.
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Aspberg, AndersLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)medk-aas
(author)
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Oldberg, ÅkeLund University,Lunds universitet,Åke Oldbergs forskargrupp,Forskargrupper vid Lunds universitet,Åke Oldberg´s group,Lund University Research Groups(Swepub:lu)medk-aog
(author)
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Åke Oldbergs forskargruppForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:Journal of Biological Chemistry282:22, s. 16062-160671083-351X
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