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Imaging in gynecolo...
Imaging in gynecological disease (27) : clinical and ultrasound characteristics of recurrent ovarian stromal cell tumors
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- Moro, F. (författare)
- Policlinico Universitario Agostino Gemelli
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- Giudice, M. T. (författare)
- Policlinico Universitario Agostino Gemelli
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- Bolomini, G. (författare)
- Policlinico Universitario Agostino Gemelli
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- Moruzzi, M. C. (författare)
- Policlinico Universitario Agostino Gemelli
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- Mascilini, F. (författare)
- Policlinico Universitario Agostino Gemelli
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- Quagliozzi, L. (författare)
- Policlinico Universitario Agostino Gemelli
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- Ciccarone, F. (författare)
- Policlinico Universitario Agostino Gemelli
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- Scambia, G. (författare)
- Catholic University of the Sacred Heart, Rome,Policlinico Universitario Agostino Gemelli
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- Fagotti, A. (författare)
- Policlinico Universitario Agostino Gemelli,Catholic University of the Sacred Heart, Rome
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- Valentin, L. (författare)
- Lund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups,Skåne University Hospital
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- Testa, A. C. (författare)
- Catholic University of the Sacred Heart, Rome,Policlinico Universitario Agostino Gemelli
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(creator_code:org_t)
- Engelska.
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Ingår i: Ultrasound in Obstetrics and Gynecology. - 0960-7692.
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: To describe the clinical and ultrasound characteristics of recurrent granulosa cell and Sertoli–Leydig cell tumors. Methods: This was a retrospective observational study performed at Fondazione Policlinico Universitario A. Gemelli, Istituto di Ricovero e Cura a Carattere Scientifico, IRCCS, Rome (Gemelli center). Patients with a histological diagnosis of recurrent granulosa cell tumor or Sertoli–Leydig cell tumor were identified from the database of the Department of Gynecological Oncology. Those who had undergone a preoperative ultrasound examination at the Gemelli center between 2012 and 2020 were included, and the data retrieved from the original ultrasound reports. In all of these reports, the recurrent tumors were described using International Ovarian Tumor Analysis (IOTA) terminology. If a patient had more than one episode of relapse, information from all episodes was collected. If there was more than one recurrent tumor at the same ultrasound examination, all tumors were included. One expert sonographer also reviewed all available ultrasound images to identify typical ultrasound patterns using pattern recognition. Results: We identified 30 patients with a histological diagnosis of recurrent granulosa cell tumor (25 patients, 55 tumors) or Sertoli–Leydig cell tumor (five patients, seven tumors). All 30 had undergone at least one preoperative ultrasound examination at the Gemelli center and were included. These women had a total of 66 episodes of relapse, of which a preoperative ultrasound examination had been performed at the Gemelli center in 34, revealing 62 recurrent lesions: one in 22/34 (64.7%) episodes of relapse, two in 4/34 (11.8%) episodes and three or more in 8/34 (23.5%) episodes. Most recurrent granulosa cell tumors (38/55, 69.1%) and recurrent Sertoli–Leydig tumors (6/7, 85.7%) were classified as solid or multilocular-solid tumors, while 8/55 (14.5%) recurrent granulosa cell tumors and 1/7 (14.3%) recurrent Sertoli–Leydig cell tumors were unilocular cysts and 9/55 (16.4%) recurrent granulosa cell tumors were multilocular cysts. The nine unilocular cysts had contents that were anechoic (n = 2) or had low-level echogenicity (n = 7), had either smooth (n = 4) or irregular (n = 5) internal cyst walls, and ranged in largest diameter from 8 to 38 mm, with three being < 20 mm and five being 20–30 mm. On retrospective review of the images, two typical ultrasound patterns were described: small solid tumor measuring < 2 cm (15/62, 24.2%) and tumor with vascularized echogenic ground-glass-like content (12/62, 19.4%). Conclusions: Some granulosa cell and Sertoli–Leydig cell recurrences manifest one of two typical ultrasound patterns, while some appear as unilocular cysts. These are usually classified as benign, but in patients being followed up for a granulosa cell tumor or Sertoli–Leydig cell tumor, a unilocular cyst should be considered suspicious of recurrence.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- granulosa cell tumor
- ovarian neoplasm
- recurrent tumor
- Sertoli–Leydig cell tumor
- ultrasonography
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Moro, F.
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Giudice, M. T.
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Bolomini, G.
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Moruzzi, M. C.
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Mascilini, F.
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Quagliozzi, L.
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visa fler...
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Ciccarone, F.
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Scambia, G.
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Fagotti, A.
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Valentin, L.
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Testa, A. C.
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Ultrasound in Ob ...
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Lunds universitet