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Structure and ion-r...
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Grønberg, ChristinaDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark
(author)
Structure and ion-release mechanism of P IB-4-type ATPases
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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eLife Sciences Publications Ltd,2022
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21 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:975c5e6d-df96-471b-9f67-dbe07791f8a3
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https://lup.lub.lu.se/record/975c5e6d-df96-471b-9f67-dbe07791f8a3URI
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https://doi.org/10.7554/eLife.73124DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191395URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Abstract Transition metals, such as zinc, are essential micronutrients in all organisms, but alsohighly toxic in excessive amounts. Heavy-metal transporting P-type (PIB) ATPases are crucial forhomeostasis, conferring cellular detoxification and redistribution through transport of these ionsacross cellular membranes. No structural information is available for the PIB-4-ATPases, the subclasswith the broadest cargo scope, and hence even their topology remains elusive. Here, we presentstructures and complementary functional analyses of an archetypal PIB-4-ATPase, sCoaT fromSulfitobacter sp. NAS14-1. The data disclose the architecture, devoid of classical so-called heavy-metal-binding domains (HMBDs), and provide fundamentally new insights into the mechanism anddiversity of heavy-metal transporters. We reveal several novel P-type ATPase features, includinga dual role in heavy-metal release and as an internal counter ion of an invariant histidine. We alsoestablish that the turnover of PIB-ATPases is potassium independent, contrasting to many otherP-type ATPases. Combined with new inhibitory compounds, our results open up for efforts in forexample drug discovery, since PIB-4-ATPases function as virulence factors in many pathogens.
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Hu, QiaoxiaDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark
(author)
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Mahato, Dhani RamUmeå universitet,Umeå University,Kemiska institutionen(Swepub:umu)dhra0002
(author)
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Longhin, ElenaDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark
(author)
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Salustros, NinaDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark
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Duelli, AnnetteDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark
(author)
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Lyu, PinDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark
(author)
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Bågenholm, ViktoriaDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark(Swepub:lu)bioc-vob
(author)
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Eriksson, JonasUmeå universitet,Umeå University,Kemiska institutionen(Swepub:umu)joer0061
(author)
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Umashankar Rao, KomalLund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Department of Laboratory Medicine, Lund University, Klinikgatan 28, Lund, Sweden(Swepub:lu)ko3044um
(author)
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Henderson, Domhnall IainDepartment of Laboratory Medicine, Lund University, Klinikgatan 28, Lund, Sweden
(author)
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Meloni, GabrieleDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd., TX, Richardson, United States
(author)
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Andersson, MagnusUmeå universitet,Umeå University,Kemiska institutionen(Swepub:umu)maan0701
(author)
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Croll, TristanCambridge Institute for Medical Research, Department of Haematology, University of Cambridge, Keith Peters Building, Hills Rd, Cambridge, United Kingdom
(author)
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Godaly, GabrielaLund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine,Medical Microbiology,Lund University Research Groups,Department of Laboratory Medicine, Lund University, Klinikgatan 28, Lund, Sweden(Swepub:lu)mmb-ggo
(author)
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Wang, KaituoDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark
(author)
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Gourdon, PontusLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine,Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark; Department of Experimental Medical Science, Lund University, Sölvegatan 19, Lund, Sweden(Swepub:lu)med-pgd
(author)
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Umeå UniversityDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark
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In:eLife: eLife Sciences Publications Ltd2050-084X
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Hu, Qiaoxia
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Mahato, Dhani Ra ...
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Longhin, Elena
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Salustros, Nina
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Duelli, Annette
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Lyu, Pin
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Bågenholm, Vikto ...
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Meloni, Gabriele
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Croll, Tristan
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Godaly, Gabriela
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Wang, Kaituo
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Gourdon, Pontus
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