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  • Grønberg, ChristinaDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark (author)

Structure and ion-release mechanism of P IB-4-type ATPases

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • eLife Sciences Publications Ltd,2022
  • 21 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:975c5e6d-df96-471b-9f67-dbe07791f8a3
  • https://lup.lub.lu.se/record/975c5e6d-df96-471b-9f67-dbe07791f8a3URI
  • https://doi.org/10.7554/eLife.73124DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191395URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Abstract Transition metals, such as zinc, are essential micronutrients in all organisms, but alsohighly toxic in excessive amounts. Heavy-metal transporting P-type (PIB) ATPases are crucial forhomeostasis, conferring cellular detoxification and redistribution through transport of these ionsacross cellular membranes. No structural information is available for the PIB-4-ATPases, the subclasswith the broadest cargo scope, and hence even their topology remains elusive. Here, we presentstructures and complementary functional analyses of an archetypal PIB-4-ATPase, sCoaT fromSulfitobacter sp. NAS14-1. The data disclose the architecture, devoid of classical so-called heavy-metal-binding domains (HMBDs), and provide fundamentally new insights into the mechanism anddiversity of heavy-metal transporters. We reveal several novel P-type ATPase features, includinga dual role in heavy-metal release and as an internal counter ion of an invariant histidine. We alsoestablish that the turnover of PIB-ATPases is potassium independent, contrasting to many otherP-type ATPases. Combined with new inhibitory compounds, our results open up for efforts in forexample drug discovery, since PIB-4-ATPases function as virulence factors in many pathogens.

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  • Hu, QiaoxiaDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark (author)
  • Mahato, Dhani RamUmeå universitet,Umeå University,Kemiska institutionen(Swepub:umu)dhra0002 (author)
  • Longhin, ElenaDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark (author)
  • Salustros, NinaDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark (author)
  • Duelli, AnnetteDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark (author)
  • Lyu, PinDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark (author)
  • Bågenholm, ViktoriaDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark(Swepub:lu)bioc-vob (author)
  • Eriksson, JonasUmeå universitet,Umeå University,Kemiska institutionen(Swepub:umu)joer0061 (author)
  • Umashankar Rao, KomalLund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Department of Laboratory Medicine, Lund University, Klinikgatan 28, Lund, Sweden(Swepub:lu)ko3044um (author)
  • Henderson, Domhnall IainDepartment of Laboratory Medicine, Lund University, Klinikgatan 28, Lund, Sweden (author)
  • Meloni, GabrieleDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd., TX, Richardson, United States (author)
  • Andersson, MagnusUmeå universitet,Umeå University,Kemiska institutionen(Swepub:umu)maan0701 (author)
  • Croll, TristanCambridge Institute for Medical Research, Department of Haematology, University of Cambridge, Keith Peters Building, Hills Rd, Cambridge, United Kingdom (author)
  • Godaly, GabrielaLund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine,Medical Microbiology,Lund University Research Groups,Department of Laboratory Medicine, Lund University, Klinikgatan 28, Lund, Sweden(Swepub:lu)mmb-ggo (author)
  • Wang, KaituoDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark (author)
  • Gourdon, PontusLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine,Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark; Department of Experimental Medical Science, Lund University, Sölvegatan 19, Lund, Sweden(Swepub:lu)med-pgd (author)
  • Umeå UniversityDepartment of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark (creator_code:org_t)

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  • In:eLife: eLife Sciences Publications Ltd2050-084X

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