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  • Chen, Kang (author)

Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-06-28
  • Springer Science and Business Media LLC,2009

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:9827d555-9fe0-4af3-aba4-f0b42718d772
  • https://lup.lub.lu.se/record/1461428URI
  • https://doi.org/10.1038/ni.1748DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell-dependent and T cell-independent IgM-to-IgD class switching in B cells of the human upper respiratory mucosa. This process required activation-induced cytidine deaminase (AID) and generated local and circulating IgD-producing plasmablasts reactive to respiratory bacteria. Circulating IgD bound to basophils through a calcium-mobilizing receptor that induced antimicrobial, opsonizing, inflammatory and B cell-stimulating factors, including cathelicidin, interleukin 1 (IL-1), IL-4 and B cell-activating factor (BAFF), after IgD crosslinking. By showing dysregulation of IgD class-switched B cells and 'IgD-armed' basophils in autoinflammatory syndromes with periodic fever, our data indicate that IgD orchestrates an ancestral surveillance system at the interface between immunity and inflammation.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Xu, Weifeng (author)
  • Wilson, Melanie (author)
  • He, Bing (author)
  • Miller, Norman W. (author)
  • Bengten, Eva (author)
  • Edholm, Eva-Stina (author)
  • Santini, Paul A. (author)
  • Rath, Poonam (author)
  • Chiu, April (author)
  • Cattalini, Marco (author)
  • Litzman, Jiri (author)
  • Bussel, James B. (author)
  • Huang, Bihui (author)
  • Meini, Antonella (author)
  • Riesbeck, KristianLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)mikr-kri (author)
  • Cunningham-Rundles, Charlotte (author)
  • Plebani, Alessandro (author)
  • Cerutti, Andrea (author)
  • Klinisk mikrobiologi, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Nature Immunology: Springer Science and Business Media LLC10:8, s. 121-8891529-29081529-2916

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