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Associations of Mat...
Associations of Maternal Diabetes During Pregnancy with Overweight in Offspring : Results from the Prospective TEDDY Study
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- Pitchika, Anitha (författare)
- Helmholtz Zentrum München,Technical University of Munich,Klinikum rechts der Isar
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- Vehik, Kendra (författare)
- University of South Florida
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- Hummel, Sandra (författare)
- Helmholtz Zentrum München,Technical University of Munich,Klinikum rechts der Isar
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- Norris, Jill M. (författare)
- University of Colorado
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- Uusitalo, Ulla M. (författare)
- University of South Florida
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- Yang, Jimin (författare)
- University of South Florida
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- Virtanen, Suvi M. (författare)
- Pirkanmaa Hospital District,University of Tampere,Tampere University Hospital,Finnish National Institute for Health and Welfare
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- Koletzko, Sibylle (författare)
- Dr. von Haunersches Kinderspital
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- Andrén Aronsson, Carin (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Ziegler, Anette G. (författare)
- Technical University of Munich,Klinikum rechts der Isar,Helmholtz Zentrum München
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- Beyerlein, Andreas (författare)
- Technical University of Munich,Klinikum rechts der Isar,Helmholtz Zentrum München
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(creator_code:org_t)
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- 2018-09-17
- 2018
- Engelska 10 s.
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Ingår i: Obesity. - : Wiley. - 1930-7381 .- 1930-739X. ; 26:9, s. 1457-1466
- Relaterad länk:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Objective: This study aimed to determine the relationship between different forms of, and potential pathways between, maternal diabetes and childhood obesity at different ages. Methods: Prospective cohort data from The Environmental Determinants of Diabetes in the Young (TEDDY) study, which was composed of 5,324 children examined from 0.25 to 6 years of age, were analyzed. Cross-sectional and longitudinal analyses taking into account potential confounders and effect modifiers such as maternal prepregnancy BMI and birth weight z scores were performed. Results: Offspring of mothers with gestational diabetes mellitus (GDM) or type 1 diabetes mellitus (T1DM) showed a higher BMI standard deviation score and increased risk for overweight and obesity at 5.5 years of age than offspring of mothers without diabetes. While these associations could be substantially explained by maternal prepregnancy BMI in offspring of mothers with GDM, significant associations disappeared after adjustment for birth weight z scores in offspring of T1DM mothers. Furthermore, overweight risk became stronger with increasing age in offspring of mothers with diabetes compared with offspring of mothers without diabetes. Conclusions: Maternal diabetes is associated with increased risk of offspring overweight, and the association appears to get stronger as children grow older. Indeed, intrauterine exposure to maternal T1DM may predispose children to later obesity through increased birth weight, while maternal BMI is more important in children exposed to GDM.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Obesity
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Pitchika, Anitha
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Vehik, Kendra
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Hummel, Sandra
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Norris, Jill M.
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Uusitalo, Ulla M ...
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Yang, Jimin
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visa fler...
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Virtanen, Suvi M ...
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Koletzko, Sibyll ...
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Andrén Aronsson, ...
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Ziegler, Anette ...
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Beyerlein, Andre ...
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