Tracking the neurodegeneration of parkinsonian disorders - A pilot study

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Nilsson, ChristerSkåne University Hospital (author)

Tracking the neurodegeneration of parkinsonian disorders - A pilot study

Article/chapterEnglish2007

Publisher, publication year, extent ...

2007-01-03
Springer Science and Business Media LLC,2007
9 s.

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LIBRIS-ID:oai:lup.lub.lu.se:986d3a14-9167-453b-babe-482de481c9ce
https://lup.lub.lu.se/record/165172URI
https://doi.org/10.1007/s00234-006-0165-1DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

The purpose of the study was to explore the possibilities of using diffusion tensor imaging (DTI) and tractography (DTT) for the differential diagnosis and monitoring of disease progression in idiopathic Parkinson's disease (IPD), compared with the atypical parkinsonian disorders multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). A 3.0-T MR scanner was used. DTI was acquired using a single-shot EPI sequence with diffusion encoding in 32 directions and a voxel size of 2×2×2 mm3. DTI data were analysed and DTT was performed using the PRIDE fibre tracking tool supplied by the manufacturer. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) within each tract were determined. DTI and DTT images in patients with moderate to advanced MSA demonstrated degeneration of the middle cerebellar peduncles and pontine crossing tracts, with decreased FA and increased ADC. This accounted for most of the pontine and cerebellar atrophy characteristic of this disease. In contrast, patients with PSP showed a selective degeneration of the superior cerebellar peduncle. Three-dimensional images of whole-brain white matter tracts demonstrated a reduction of cortical projection fibres in all patients with PSP. Visualization of the selective degeneration of individual fibre tracts, using DTI and DTT, adds qualitative data facilitating the differential diagnosis of parkinsonian disorders. Repeated measurements of FA and ADC values in a whole fibre tract might be used for monitoring disease progression and studying the effect of treatment in neuroprotective trials. The results are preliminary considering the small number of subjects in the study. © Springer-Verlag 2007.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Annan klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Other Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
Diffusion
Magnetic resonance imaging
Multiple system atrophy
Parkinson's disease
Progressive supranuclear palsy
adult
aged
anisotropy
article
cerebellum atrophy
clinical article
controlled study
diagnostic value
differential diagnosis
diffusion coefficient
diffusion tensor imaging
disease course
female
human
male
nerve degeneration
nerve projection
Parkinson disease
parkinsonism
pilot study
priority journal
progressive supranuclear palsy
qualitative analysis
Shy Drager syndrome
three dimensional imaging
white matter

Added entries (persons, corporate bodies, meetings, titles ...)

Markenroth Bloch, KarinPhilips Medical Systems(Swepub:lu)klin-km0 (author)
Brockstedt, SaraLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)rafy-sbr (author)
Lätt, J.Skåne University Hospital(Swepub:lu)radf-jla (author)
Widner, HåkanLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)mphy-hwi (author)
Larsson, Elna-MarieLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)drad-eml (author)
Skåne University HospitalPhilips Medical Systems (creator_code:org_t)

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In:Neuroradiology: Springer Science and Business Media LLC49:2, s. 111-1191432-19200028-3940

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