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  • Ibanez, BorjaHospital Fundación Jiménez Díaz,Centro Nacional de Investigaciones Cardiovasculares Carlos III (author)

Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials : JACC Scientific Expert Panel

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • Elsevier BV,2019
  • 19 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:987ccd98-25f8-45a9-8257-3ad8efd19186
  • https://lup.lub.lu.se/record/987ccd98-25f8-45a9-8257-3ad8efd19186URI
  • https://doi.org/10.1016/j.jacc.2019.05.024DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:for swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema, inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and ultimately replacement by fibrosis). The extension and magnitude of these changes contribute to long-term prognosis after MI. Cardiac magnetic resonance (CMR) is the gold-standard technique for noninvasive myocardial tissue characterization. CMR is also the preferred methodology for the identification of potential benefits associated with new cardioprotective strategies both in experimental and clinical trials. However, there is a wide heterogeneity in CMR methodologies used in experimental and clinical trials, including time of post-MI scan, acquisition protocols, and, more importantly, selection of endpoints. There is a need for standardization of these methodologies to improve the translation into a real clinical benefit. The main objective of this scientific expert panel consensus document is to provide recommendations for CMR endpoint selection in experimental and clinical trials based on pathophysiology and its association with hard outcomes.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Aletras, Anthony H.Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Cardiac MR Group,Lund University Research Groups,Aristotle University of Thessaloniki(Swepub:lu)med-aya (author)
  • Arai, Andrew E.National Heart Lung and Blood Institute (author)
  • Arheden, HakanLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Cardiac MR Group,Lund University Research Groups(Swepub:lu)klfy-har (author)
  • Bax, JeroenLeiden University Medical Centre (author)
  • Berry, ColinUniversity of Glasgow (author)
  • Bucciarelli-Ducci, ChiaraUniversity of Bristol (author)
  • Croisille, PierreUniversity of Lyon (author)
  • Dall'Armellina, EricaUniversity of Leeds (author)
  • Dharmakumar, RohanUniversity of California, Los Angeles (author)
  • Eitel, IngoGerman Centre for Cardiovascular Research (author)
  • Fernández-Jiménez, RodrigoCentro Nacional de Investigaciones Cardiovasculares Carlos III,Icahn School of Medicine at Mount Sinai (author)
  • Friedrich, Matthias G.Heidelberg University,McGill University (author)
  • García-Dorado, DavidAutonomous University of Barcelona (author)
  • Hausenloy, Derek J.University College London,National University of Singapore (author)
  • Kim, Raymond J.Duke University Medical Center (author)
  • Kozerke, SebastianETH Zürich (author)
  • Kramer, Christopher M.University of Virginia Health System (author)
  • Salerno, MichaelUniversity of Virginia Health System (author)
  • Sánchez-González, JavierPhilips Healthcare Netherlands (author)
  • Sanz, JavierCentro Nacional de Investigaciones Cardiovasculares Carlos III,Icahn School of Medicine at Mount Sinai (author)
  • Fuster, ValentinCentro Nacional de Investigaciones Cardiovasculares Carlos III,Icahn School of Medicine at Mount Sinai (author)
  • Hospital Fundación Jiménez DíazCentro Nacional de Investigaciones Cardiovasculares Carlos III (creator_code:org_t)

Related titles

  • In:Journal of the American College of Cardiology: Elsevier BV74:2, s. 238-2560735-1097

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