SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Poy Matthew N)
 

Search: WFRF:(Poy Matthew N) > (2014) > Argonaute2 Mediates...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Tattikota, Sudhir G (author)

Argonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell.

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • Elsevier BV,2014
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:98e5f289-e270-4fe1-9467-30459d28957f
  • https://lup.lub.lu.se/record/4223353URI
  • https://doi.org/10.1016/j.cmet.2013.11.015DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Pancreatic β cells adapt to compensate for increased metabolic demand during insulin resistance. Although the microRNA pathway has an essential role in β cell proliferation, the extent of its contribution is unclear. Here, we report that miR-184 is silenced in the pancreatic islets of insulin-resistant mouse models and type 2 diabetic human subjects. Reduction of miR-184 promotes the expression of its target Argonaute2 (Ago2), a component of the microRNA-induced silencing complex. Moreover, restoration of miR-184 in leptin-deficient ob/ob mice decreased Ago2 and prevented compensatory β cell expansion. Loss of Ago2 during insulin resistance blocked β cell growth and relieved the regulation of miR-375-targeted genes, including the growth suppressor Cadm1. Lastly, administration of a ketogenic diet to ob/ob mice rescued insulin sensitivity and miR-184 expression and restored Ago2 and β cell mass. This study identifies the targeting of Ago2 by miR-184 as an essential component of the compensatory response to regulate proliferation according to insulin sensitivity.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rathjen, Thomas (author)
  • McAnulty, Sarah J (author)
  • Wessels, Hans-Hermann (author)
  • Akerman, Ildem (author)
  • van de Bunt, Martijn (author)
  • Hausser, Jean (author)
  • Esguerra, JonathanLund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups(Swepub:lu)med-jer (author)
  • Musahl, Anne (author)
  • Pandey, Amit K (author)
  • You, Xintian (author)
  • Chen, Wei (author)
  • Herrera, Pedro L (author)
  • Johnson, Paul R (author)
  • O'Carroll, Donal (author)
  • Eliasson, LenaLund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups(Swepub:lu)mphy-lel (author)
  • Zavolan, Mihaela (author)
  • Gloyn, Anna L (author)
  • Ferrer, Jorge (author)
  • Shalom-Feuerstein, Ruby (author)
  • Aberdam, Daniel (author)
  • Poy, Matthew N (author)
  • Diabetes - öcellsexocytosForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Cell Metabolism: Elsevier BV19:1, s. 122-1341550-4131

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view