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Argonaute2 Mediates...
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Tattikota, Sudhir G
(author)
Argonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell.
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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Elsevier BV,2014
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:98e5f289-e270-4fe1-9467-30459d28957f
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https://lup.lub.lu.se/record/4223353URI
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https://doi.org/10.1016/j.cmet.2013.11.015DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Pancreatic β cells adapt to compensate for increased metabolic demand during insulin resistance. Although the microRNA pathway has an essential role in β cell proliferation, the extent of its contribution is unclear. Here, we report that miR-184 is silenced in the pancreatic islets of insulin-resistant mouse models and type 2 diabetic human subjects. Reduction of miR-184 promotes the expression of its target Argonaute2 (Ago2), a component of the microRNA-induced silencing complex. Moreover, restoration of miR-184 in leptin-deficient ob/ob mice decreased Ago2 and prevented compensatory β cell expansion. Loss of Ago2 during insulin resistance blocked β cell growth and relieved the regulation of miR-375-targeted genes, including the growth suppressor Cadm1. Lastly, administration of a ketogenic diet to ob/ob mice rescued insulin sensitivity and miR-184 expression and restored Ago2 and β cell mass. This study identifies the targeting of Ago2 by miR-184 as an essential component of the compensatory response to regulate proliferation according to insulin sensitivity.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Rathjen, Thomas
(author)
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McAnulty, Sarah J
(author)
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Wessels, Hans-Hermann
(author)
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Akerman, Ildem
(author)
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van de Bunt, Martijn
(author)
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Hausser, Jean
(author)
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Esguerra, JonathanLund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups(Swepub:lu)med-jer
(author)
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Musahl, Anne
(author)
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Pandey, Amit K
(author)
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You, Xintian
(author)
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Chen, Wei
(author)
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Herrera, Pedro L
(author)
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Johnson, Paul R
(author)
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O'Carroll, Donal
(author)
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Eliasson, LenaLund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups(Swepub:lu)mphy-lel
(author)
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Zavolan, Mihaela
(author)
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Gloyn, Anna L
(author)
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Ferrer, Jorge
(author)
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Shalom-Feuerstein, Ruby
(author)
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Aberdam, Daniel
(author)
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Poy, Matthew N
(author)
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Diabetes - öcellsexocytosForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Cell Metabolism: Elsevier BV19:1, s. 122-1341550-4131
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Tattikota, Sudhi ...
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Rathjen, Thomas
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McAnulty, Sarah ...
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Wessels, Hans-He ...
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Akerman, Ildem
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van de Bunt, Mar ...
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show more...
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Hausser, Jean
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Esguerra, Jonath ...
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Musahl, Anne
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Pandey, Amit K
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You, Xintian
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Chen, Wei
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Herrera, Pedro L
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Johnson, Paul R
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O'Carroll, Donal
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Eliasson, Lena
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Zavolan, Mihaela
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Gloyn, Anna L
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Ferrer, Jorge
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Shalom-Feuerstei ...
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Aberdam, Daniel
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Poy, Matthew N
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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Cell Metabolism
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Lund University