Sökning: WFRF:(Tuomi TiinaMaija) >
Smoking, use of smo...
-
Edstorp, JessicaKarolinska Institutet,Karolinska Institute
(författare)
Smoking, use of smokeless tobacco, HLA genotypes and incidence of latent autoimmune diabetes in adults
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
-
2022-07-28
-
Springer Science and Business Media LLC,2023
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:98f5f7e4-c289-4fec-ae63-762b9482c826
-
https://lup.lub.lu.se/record/98f5f7e4-c289-4fec-ae63-762b9482c826URI
-
https://doi.org/10.1007/s00125-022-05763-wDOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:150365414URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
Aims/hypotheses: Smoking and use of smokeless tobacco (snus) are associated with an increased risk of type 2 diabetes. We investigated whether smoking and snus use increase the risk of latent autoimmune diabetes in adults (LADA) and elucidated potential interaction with HLA high-risk genotypes. Methods: Analyses were based on Swedish case–control data (collected 2010–2019) with incident cases of LADA (n=593) and type 2 diabetes (n=2038), and 3036 controls, and Norwegian prospective data (collected 1984–2019) with incident cases of LADA (n=245) and type 2 diabetes (n=3726) during 1,696,503 person-years of follow-up. Pooled RRs with 95% CIs were estimated for smoking, and ORs for snus use (case–control data only). The interaction was assessed by attributable proportion (AP) due to interaction. A two-sample Mendelian randomisation (MR) study on smoking and LADA/type 2 diabetes was conducted based on summary statistics from genome-wide association studies. Results: Smoking (RRpooled 1.30 [95% CI 1.06, 1.59] for current vs never) and snus use (OR 1.97 [95% CI 1.20, 3.24] for ≥15 box-years vs never use) were associated with an increased risk of LADA. Corresponding estimates for type 2 diabetes were 1.38 (95% CI 1.28, 1.49) and 1.92 (95% CI 1.27, 2.90), respectively. There was interaction between smoking and HLA high-risk genotypes (AP 0.27 [95% CI 0.01, 0.53]) in relation to LADA. The positive association between smoking and LADA/type 2 diabetes was confirmed by the MR study. Conclusions/interpretation: Our findings suggest that tobacco use increases the risk of LADA and that smoking acts synergistically with genetic susceptibility in the promotion of LADA. Data availability: Analysis codes are shared through GitHub (https://github.com/jeseds/Smoking-use-of-smokeless-tobacco-HLA-genotypes-and-incidence-of-LADA). Graphical abstract: [Figure not available: see fulltext.]
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Wei, YuxiaKarolinska Institutet,Karolinska Institute
(författare)
-
Ahlqvist, EmmaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)infl-eah
(författare)
-
Alfredsson, LarsKarolinska Institutet,Karolinska Institute
(författare)
-
Grill, ValdemarNorwegian University of Science and Technology
(författare)
-
Groop, LeifLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki(Swepub:lu)endo-lgr
(författare)
-
Rasouli, BaharehKarolinska Institutet,Karolinska Institute,Harvard T.H. Chan School of Public Health
(författare)
-
Sørgjerd, Elin P.Norwegian University of Science and Technology,St. Olav’s University Hospital
(författare)
-
Thorsby, Per M.Oslo university hospital
(författare)
-
Tuomi, TiinamaijaLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Translational Muscle Research,Lund University Research Groups,University of Helsinki(Swepub:lu)ti8736tu
(författare)
-
Åsvold, Bjørn O.Norwegian University of Science and Technology,St. Olav’s University Hospital
(författare)
-
Carlsson, SofiaKarolinska Institutet,Karolinska Institute
(författare)
-
Karolinska InstitutetKarolinska Institute
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Diabetologia: Springer Science and Business Media LLC66, s. 70-810012-186X1432-0428
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Edstorp, Jessica
-
Wei, Yuxia
-
Ahlqvist, Emma
-
Alfredsson, Lars
-
Grill, Valdemar
-
Groop, Leif
-
visa fler...
-
Rasouli, Bahareh
-
Sørgjerd, Elin P ...
-
Thorsby, Per M.
-
Tuomi, Tiinamaij ...
-
Åsvold, Bjørn O.
-
Carlsson, Sofia
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Diabetologia
- Av lärosätet
-
Lunds universitet
-
Karolinska Institutet