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  • Edstorp, JessicaKarolinska Institutet,Karolinska Institute (författare)

Smoking, use of smokeless tobacco, HLA genotypes and incidence of latent autoimmune diabetes in adults

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2022-07-28
  • Springer Science and Business Media LLC,2023

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:98f5f7e4-c289-4fec-ae63-762b9482c826
  • https://lup.lub.lu.se/record/98f5f7e4-c289-4fec-ae63-762b9482c826URI
  • https://doi.org/10.1007/s00125-022-05763-wDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150365414URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Aims/hypotheses: Smoking and use of smokeless tobacco (snus) are associated with an increased risk of type 2 diabetes. We investigated whether smoking and snus use increase the risk of latent autoimmune diabetes in adults (LADA) and elucidated potential interaction with HLA high-risk genotypes. Methods: Analyses were based on Swedish case–control data (collected 2010–2019) with incident cases of LADA (n=593) and type 2 diabetes (n=2038), and 3036 controls, and Norwegian prospective data (collected 1984–2019) with incident cases of LADA (n=245) and type 2 diabetes (n=3726) during 1,696,503 person-years of follow-up. Pooled RRs with 95% CIs were estimated for smoking, and ORs for snus use (case–control data only). The interaction was assessed by attributable proportion (AP) due to interaction. A two-sample Mendelian randomisation (MR) study on smoking and LADA/type 2 diabetes was conducted based on summary statistics from genome-wide association studies. Results: Smoking (RRpooled 1.30 [95% CI 1.06, 1.59] for current vs never) and snus use (OR 1.97 [95% CI 1.20, 3.24] for ≥15 box-years vs never use) were associated with an increased risk of LADA. Corresponding estimates for type 2 diabetes were 1.38 (95% CI 1.28, 1.49) and 1.92 (95% CI 1.27, 2.90), respectively. There was interaction between smoking and HLA high-risk genotypes (AP 0.27 [95% CI 0.01, 0.53]) in relation to LADA. The positive association between smoking and LADA/type 2 diabetes was confirmed by the MR study. Conclusions/interpretation: Our findings suggest that tobacco use increases the risk of LADA and that smoking acts synergistically with genetic susceptibility in the promotion of LADA. Data availability: Analysis codes are shared through GitHub (https://github.com/jeseds/Smoking-use-of-smokeless-tobacco-HLA-genotypes-and-incidence-of-LADA). Graphical abstract: [Figure not available: see fulltext.]

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wei, YuxiaKarolinska Institutet,Karolinska Institute (författare)
  • Ahlqvist, EmmaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)infl-eah (författare)
  • Alfredsson, LarsKarolinska Institutet,Karolinska Institute (författare)
  • Grill, ValdemarNorwegian University of Science and Technology (författare)
  • Groop, LeifLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki(Swepub:lu)endo-lgr (författare)
  • Rasouli, BaharehKarolinska Institutet,Karolinska Institute,Harvard T.H. Chan School of Public Health (författare)
  • Sørgjerd, Elin P.Norwegian University of Science and Technology,St. Olav’s University Hospital (författare)
  • Thorsby, Per M.Oslo university hospital (författare)
  • Tuomi, TiinamaijaLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Translational Muscle Research,Lund University Research Groups,University of Helsinki(Swepub:lu)ti8736tu (författare)
  • Åsvold, Bjørn O.Norwegian University of Science and Technology,St. Olav’s University Hospital (författare)
  • Carlsson, SofiaKarolinska Institutet,Karolinska Institute (författare)
  • Karolinska InstitutetKarolinska Institute (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Diabetologia: Springer Science and Business Media LLC66, s. 70-810012-186X1432-0428

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