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Smoking, use of smo...
Smoking, use of smokeless tobacco, HLA genotypes and incidence of latent autoimmune diabetes in adults
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- Edstorp, Jessica (author)
- Karolinska Institutet,Karolinska Institute
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- Wei, Yuxia (author)
- Karolinska Institutet,Karolinska Institute
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- Ahlqvist, Emma (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Alfredsson, Lars (author)
- Karolinska Institutet,Karolinska Institute
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- Grill, Valdemar (author)
- Norwegian University of Science and Technology
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- Groop, Leif (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki
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- Rasouli, Bahareh (author)
- Karolinska Institutet,Karolinska Institute,Harvard T.H. Chan School of Public Health
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- Sørgjerd, Elin P. (author)
- St. Olav’s University Hospital,Norwegian University of Science and Technology
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- Thorsby, Per M. (author)
- Oslo university hospital
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- Tuomi, Tiinamaija (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Translational Muscle Research,Lund University Research Groups,University of Helsinki
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- Åsvold, Bjørn O. (author)
- St. Olav’s University Hospital,Norwegian University of Science and Technology
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- Carlsson, Sofia (author)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- 2022-07-28
- 2023
- English.
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In: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 66, s. 70-81
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Abstract
Subject headings
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- Aims/hypotheses: Smoking and use of smokeless tobacco (snus) are associated with an increased risk of type 2 diabetes. We investigated whether smoking and snus use increase the risk of latent autoimmune diabetes in adults (LADA) and elucidated potential interaction with HLA high-risk genotypes. Methods: Analyses were based on Swedish case–control data (collected 2010–2019) with incident cases of LADA (n=593) and type 2 diabetes (n=2038), and 3036 controls, and Norwegian prospective data (collected 1984–2019) with incident cases of LADA (n=245) and type 2 diabetes (n=3726) during 1,696,503 person-years of follow-up. Pooled RRs with 95% CIs were estimated for smoking, and ORs for snus use (case–control data only). The interaction was assessed by attributable proportion (AP) due to interaction. A two-sample Mendelian randomisation (MR) study on smoking and LADA/type 2 diabetes was conducted based on summary statistics from genome-wide association studies. Results: Smoking (RRpooled 1.30 [95% CI 1.06, 1.59] for current vs never) and snus use (OR 1.97 [95% CI 1.20, 3.24] for ≥15 box-years vs never use) were associated with an increased risk of LADA. Corresponding estimates for type 2 diabetes were 1.38 (95% CI 1.28, 1.49) and 1.92 (95% CI 1.27, 2.90), respectively. There was interaction between smoking and HLA high-risk genotypes (AP 0.27 [95% CI 0.01, 0.53]) in relation to LADA. The positive association between smoking and LADA/type 2 diabetes was confirmed by the MR study. Conclusions/interpretation: Our findings suggest that tobacco use increases the risk of LADA and that smoking acts synergistically with genetic susceptibility in the promotion of LADA. Data availability: Analysis codes are shared through GitHub (https://github.com/jeseds/Smoking-use-of-smokeless-tobacco-HLA-genotypes-and-incidence-of-LADA). Graphical abstract: [Figure not available: see fulltext.]
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Gene–environment interaction
- LADA
- Latent autoimmune diabetes in adults
- Mendelian randomisation analysis
- Smoking
- Tobacco use
- ANDIS
- diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Edstorp, Jessica
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Wei, Yuxia
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Ahlqvist, Emma
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Alfredsson, Lars
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Grill, Valdemar
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Groop, Leif
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Rasouli, Bahareh
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Sørgjerd, Elin P ...
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Thorsby, Per M.
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Tuomi, Tiinamaij ...
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Åsvold, Bjørn O.
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Carlsson, Sofia
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetologia
- By the university
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Lund University
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Karolinska Institutet