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EGLN2 DNA methylati...
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Zhang, RuyangHarvard University,Nanjing Medical University
(author)
EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-01-31
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Informa UK Limited,2019
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LIBRIS-ID:oai:lup.lub.lu.se:9935919c-6fe1-4748-8fc2-a81b0b406b6b
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https://lup.lub.lu.se/record/9935919c-6fe1-4748-8fc2-a81b0b406b6bURI
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https://doi.org/10.1080/15592294.2019.1573066DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Hypoxia occurs frequently in human cancers and promotes stabilization and activation of hypoxia inducible factor (HIF). HIF-1α is specific for the hypoxia response, and its degradation mediated by three enzymes EGLN1, EGLN2 and EGLN3. Although EGLNs expression has been found to be related to prognosis of many cancers, few studies examined DNA methylation in EGLNs and its relationship to prognosis of early-stage non-small cell lung cancer (NSCLC). We analyzed EGLNs DNA methylation data from tumor tissue samples of 1,230 early-stage NSCLC patients, as well as gene expression data from The Cancer Genome Atlas. The sliding windows sequential forward feature selection method and weighted random forest were used to screen out the candidate CpG probes in lung adenocarcinomas (LUAD) and lung squamous cell carcinomas patients, respectively, in both discovery and validation phases. Then Cox regression was performed to evaluate the association between DNA methylation and overall survival. Among the 34 CpG probes in EGLNs, DNA methylation at cg25923056EGLN2 was identified to be significantly associated with LUAD survival (HR = 1.02, 95% CI: 1.01–1.03, P = 9.90 × 10–5), and correlated with EGLN2 expression (r =–0.36, P = 1.52 × 10–11). Meanwhile, EGLN2 expression was negatively correlated with HIF1A expression in tumor tissues (r =–0.30, P = 4.78 × 10–8) and significantly (P = 0.037) interacted with HIF1A expression on overall survival. Therefore, DNA methylation of EGLN2- HIF1A is a potential marker for LUAD prognosis and these genes are potential treatment targets for further development of HIF-1α inhibitors in lung cancer therapy.
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Lai, LinjingNanjing Medical University
(author)
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He, JieyuNanjing Medical University
(author)
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Chen, ChaoNanjing Medical University
(author)
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You, DongfangNanjing Medical University
(author)
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Duan, WeiweiNanjing Medical University
(author)
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Dong, XuesiNanjing Medical University,Southeast University
(author)
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Zhu, YingNanjing Medical University
(author)
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Lin, LijuanNanjing Medical University
(author)
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Shen, SipengHarvard University,Nanjing Medical University
(author)
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Guo, YichenHarvard University
(author)
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Su, LiNanjing Medical University,Harvard University
(author)
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Shafer, AndreaMassachusetts General Hospital,Harvard University
(author)
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Moran, SebastianBellvitge Biomedical Research Institute,University of Barcelona,Catalan Institution for Research and Advanced Studies
(author)
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Fleischer, ThomasOslo university hospital
(author)
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Bjaanæs, Maria MoksnesOslo university hospital
(author)
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Karlsson, AnnaLund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups(Swepub:lu)med-akn
(author)
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Planck, MariaLund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups(Swepub:lu)onk-mpl
(author)
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Staaf, JohanLund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups(Swepub:lu)onk-jst
(author)
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Helland, ÅslaugOslo university hospital,University of Oslo
(author)
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Esteller, ManelBellvitge Biomedical Research Institute,Catalan Institution for Research and Advanced Studies,University of Barcelona
(author)
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Wei, YongyueNanjing Medical University,Harvard University
(author)
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Chen, FengNanjing Medical University
(author)
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Christiani, David C.Massachusetts General Hospital,Nanjing Medical University,Harvard University
(author)
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Harvard UniversityNanjing Medical University
(creator_code:org_t)
Related titles
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In:Epigenetics: Informa UK Limited14:2, s. 118-1291559-22941559-2308
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- By the author/editor
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Zhang, Ruyang
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Lai, Linjing
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He, Jieyu
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Chen, Chao
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You, Dongfang
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Duan, Weiwei
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show more...
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Dong, Xuesi
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Zhu, Ying
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Lin, Lijuan
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Shen, Sipeng
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Guo, Yichen
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Su, Li
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Shafer, Andrea
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Moran, Sebastian
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Fleischer, Thoma ...
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Bjaanæs, Maria M ...
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Karlsson, Anna
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Planck, Maria
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Staaf, Johan
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Helland, Åslaug
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Esteller, Manel
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Wei, Yongyue
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Chen, Feng
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Christiani, Davi ...
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and Basic Medicine
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and Medical Genetics
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Epigenetics
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Lund University