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Variants in MTNR1B ...
Variants in MTNR1B influence fasting glucose levels
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Prokopenko, Inga (author)
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Langenberg, Claudia (author)
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Florez, Jose C. (author)
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show more...
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Saxena, Richa (author)
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Soranzo, Nicole (author)
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Thorleifsson, Gudmar (author)
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Loos, Ruth J. F. (author)
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Manning, Alisa K. (author)
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Jackson, Anne U. (author)
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Aulchenko, Yurii (author)
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Potter, Simon C. (author)
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Erdos, Michael R. (author)
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Sanna, Serena (author)
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Hottenga, Jouke-Jan (author)
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Wheeler, Eleanor (author)
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Kaakinen, Marika (author)
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Chen, Wei-Min (author)
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Ahmadi, Kourosh (author)
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Beckmann, Jacques S. (author)
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Bergman, Richard N. (author)
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Bochud, Murielle (author)
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Bonnycastle, Lori L. (author)
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Buchanan, Thomas A. (author)
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Cao, Antonio (author)
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Cervino, Alessandra (author)
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Coin, Lachlan (author)
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Collins, Francis S. (author)
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Crisponi, Laura (author)
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De Geus, Eco J. C. (author)
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Dehghan, Abbas (author)
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Deloukas, Panos (author)
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Doney, Alex S. F. (author)
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Elliott, Paul (author)
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Freimer, Nelson (author)
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Gateva, Vesela (author)
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Herder, Christian (author)
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Hofman, Albert (author)
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Hughes, Thomas E. (author)
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Hunt, Sarah (author)
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Illig, Thomas (author)
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Inouye, Michael (author)
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Isomaa, Bo (author)
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Johnson, Toby (author)
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Kong, Augustine (author)
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Krestyaninova, Maria (author)
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Kuusisto, Johanna (author)
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Laakso, Markku (author)
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Lim, Noha (author)
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- Lindblad, Ulf (author)
- Gothenburg University,Göteborgs universitet,Lund University,Lunds universitet,Samhällsmedicin,Forskargrupper vid Lunds universitet,Community Medicine,Lund University Research Groups,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Lindgren, Cecilia M. (author)
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McCann, Owen T. (author)
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Mohlke, Karen L. (author)
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Morris, Andrew D. (author)
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Naitza, Silvia (author)
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Orru, Marco (author)
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Palmer, Colin N. A. (author)
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Pouta, Anneli (author)
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Randall, Joshua (author)
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Rathmann, Wolfgang (author)
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Saramies, Jouko (author)
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Scheet, Paul (author)
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Scott, Laura J. (author)
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Scuteri, Angelo (author)
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Sharp, Stephen (author)
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Sijbrands, Eric (author)
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Smit, Jan H. (author)
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Song, Kijoung (author)
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Steinthorsdottir, Valgerdur (author)
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Stringham, Heather M. (author)
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Tuomi, Tiinamaija (author)
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Tuomilehto, Jaakko (author)
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Uitterlinden, Andre G. (author)
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Voight, Benjamin F. (author)
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Waterworth, Dawn (author)
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Wichmann, H-Erich (author)
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Willemsen, Gonneke (author)
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Witteman, Jacqueline C. M. (author)
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Yuan, Xin (author)
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Zhao, Jing Hua (author)
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Zeggini, Eleftheria (author)
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Schlessinger, David (author)
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Sandhu, Manjinder (author)
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Boomsma, Dorret I. (author)
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Uda, Manuela (author)
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Spector, Tim D. (author)
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Penninx, Brenda W. J. H. (author)
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Altshuler, David (author)
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Vollenweider, Peter (author)
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Jarvelin, Marjo Riitta (author)
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Lakatta, Edward (author)
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Waeber, Gerard (author)
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Fox, Caroline S. (author)
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Peltonen, Leena (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Mooser, Vincent (author)
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Cupples, L. Adrienne (author)
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Thorsteinsdottir, Unnur (author)
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Boehnke, Michael (author)
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Barroso, Ines (author)
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Van Duijn, Cornelia (author)
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Dupuis, Josee (author)
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Watanabe, Richard M. (author)
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Stefansson, Kari (author)
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McCarthy, Mark I. (author)
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Wareham, Nicholas J. (author)
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Meigs, James B. (author)
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Abecasis, Goncalo R. (author)
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(creator_code:org_t)
- 2008-12-07
- 2009
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:1, s. 77-81
- Related links:
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http://dx.doi.org/10...
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https://cdr.lib.unc....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Subject headings
Close
- To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 x 10(-50)) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B, P = 1.1 x 10(-15)). The same allele was associated with an increased risk of type 2 diabetes (odds ratio = 1.09 (1.05-1.12), per G allele P = 3.3 x 10(-7)) in a meta-analysis of 13 case-control studies totaling 18,236 cases and 64,453 controls. Our analyses also confirm previous associations of fasting glucose with variants at the G6PC2 (rs560887, P = 1.1 x 10(-57)) and GCK (rs4607517, P = 1.0 x 10(-25)) loci.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Prokopenko, Inga
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Langenberg, Clau ...
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Florez, Jose C.
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Saxena, Richa
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Soranzo, Nicole
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Thorleifsson, Gu ...
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show more...
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Loos, Ruth J. F.
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Manning, Alisa K ...
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Jackson, Anne U.
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Aulchenko, Yurii
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Potter, Simon C.
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Erdos, Michael R ...
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Sanna, Serena
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Hottenga, Jouke- ...
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Wheeler, Eleanor
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Kaakinen, Marika
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Lyssenko, Valeri ...
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Chen, Wei-Min
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Ahmadi, Kourosh
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Beckmann, Jacque ...
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Bergman, Richard ...
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Bochud, Murielle
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Bonnycastle, Lor ...
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Buchanan, Thomas ...
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Cao, Antonio
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Cervino, Alessan ...
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Coin, Lachlan
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Collins, Francis ...
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Crisponi, Laura
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De Geus, Eco J. ...
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Dehghan, Abbas
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Deloukas, Panos
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Doney, Alex S. F ...
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Elliott, Paul
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Freimer, Nelson
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Gateva, Vesela
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Herder, Christia ...
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Hofman, Albert
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Hughes, Thomas E ...
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Hunt, Sarah
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Illig, Thomas
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Inouye, Michael
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Isomaa, Bo
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Johnson, Toby
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Kong, Augustine
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Krestyaninova, M ...
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Kuusisto, Johann ...
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Laakso, Markku
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Lim, Noha
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Lindblad, Ulf
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Lindgren, Cecili ...
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McCann, Owen T.
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Mohlke, Karen L.
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Morris, Andrew D ...
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Naitza, Silvia
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Orru, Marco
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Palmer, Colin N. ...
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Pouta, Anneli
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Randall, Joshua
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Rathmann, Wolfga ...
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Saramies, Jouko
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Scheet, Paul
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Scott, Laura J.
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Scuteri, Angelo
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Sharp, Stephen
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Sijbrands, Eric
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Smit, Jan H.
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Song, Kijoung
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Steinthorsdottir ...
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Stringham, Heath ...
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Tuomi, Tiinamaij ...
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Tuomilehto, Jaak ...
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Uitterlinden, An ...
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Voight, Benjamin ...
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Waterworth, Dawn
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Wichmann, H-Eric ...
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Willemsen, Gonne ...
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Witteman, Jacque ...
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Yuan, Xin
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Zhao, Jing Hua
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Zeggini, Elefthe ...
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Schlessinger, Da ...
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Sandhu, Manjinde ...
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Boomsma, Dorret ...
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Uda, Manuela
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Spector, Tim D.
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Penninx, Brenda ...
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Altshuler, David
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Vollenweider, Pe ...
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Jarvelin, Marjo ...
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Lakatta, Edward
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Waeber, Gerard
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Fox, Caroline S.
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Peltonen, Leena
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Groop, Leif
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Mooser, Vincent
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Cupples, L. Adri ...
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Thorsteinsdottir ...
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Boehnke, Michael
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Barroso, Ines
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Van Duijn, Corne ...
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Dupuis, Josee
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Watanabe, Richar ...
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Stefansson, Kari
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McCarthy, Mark I ...
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Wareham, Nichola ...
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Meigs, James B.
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Abecasis, Goncal ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and General Practice
- Articles in the publication
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Nature Genetics
- By the university
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Lund University
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University of Gothenburg