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Associations of pho...
Associations of phosphorylated tau pathology with whole-hemisphere ex vivo morphometry in 7 tesla MRI
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- Sadaghiani, Shokufeh (author)
- University of Pennsylvania
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- Trotman, Winifred (author)
- University of Pennsylvania
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- Lim, Sydney A. (author)
- University of Pennsylvania
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show more...
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- Chung, Eunice (author)
- University of Pennsylvania
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- Ittyerah, Ranjit (author)
- University of Pennsylvania
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- Ravikumar, Sadhana (author)
- University of Pennsylvania
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- Khandelwal, Pulkit (author)
- University of Pennsylvania
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- Prabhakaran, Karthik (author)
- University of Pennsylvania
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- Lavery, Madigan L. (author)
- University of Pennsylvania
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- Ohm, Daniel T. (author)
- University of Pennsylvania
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- Gabrielyan, Marianna (author)
- University of Pennsylvania
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- Das, Sandhitsu R. (author)
- University of Pennsylvania
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- Schuck, Theresa (author)
- University of Pennsylvania
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- Capp, Noah (author)
- University of Pennsylvania
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- Peterson, Claire S. (author)
- University of Pennsylvania
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- Migdal, Elyse (author)
- University of Pennsylvania
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- Artacho-Pérula, Emilio (author)
- University of Castilla La Mancha
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- Jiménez, María del Mar Arroyo (author)
- University of Castilla La Mancha
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- Rabal, Maria del Pilar Marcos (author)
- University of Castilla La Mancha
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- Sánchez, Sandra Cebada (author)
- University of Castilla La Mancha
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- Prieto, Carlos de la Rosa (author)
- University of Castilla La Mancha
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- Parada, Marta Córcoles (author)
- University of Castilla La Mancha
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- Insausti, Ricardo (author)
- University of Castilla La Mancha
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- Robinson, John L. (author)
- University of Pennsylvania
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- McMillan, Corey (author)
- University of Pennsylvania
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- Grossman, Murray (author)
- University of Pennsylvania
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- Lee, Edward B. (author)
- University of Pennsylvania
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- Detre, John A. (author)
- University of Pennsylvania
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- Xie, Sharon X. (author)
- University of Pennsylvania
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- Trojanowski, John Q. (author)
- University of Pennsylvania
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- Tisdall, M. Dylan (author)
- University of Pennsylvania
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- Wisse, Laura E.M. (author)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,University of Pennsylvania
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- Irwin, David J. (author)
- University of Pennsylvania
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- Wolk, David A. (author)
- University of Pennsylvania
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- Yushkevich, Paul A. (author)
- University of Pennsylvania
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(creator_code:org_t)
- 2022-12-04
- 2023
- English 10 s.
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In: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 19:6, s. 2355-2364
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Introduction: Neurodegenerative disorders are associated with different pathologies that often co-occur but cannot be measured specifically with in vivo methods. Methods: Thirty-three brain hemispheres from donors with an Alzheimer's disease (AD) spectrum diagnosis underwent T2-weighted magnetic resonance imaging (MRI). Gray matter thickness was paired with histopathology from the closest anatomic region in the contralateral hemisphere. Results: Partial Spearman correlation of phosphorylated tau and cortical thickness with TAR DNA-binding protein 43 (TDP-43) and α-synuclein scores, age, sex, and postmortem interval as covariates showed significant relationships in entorhinal and primary visual cortices, temporal pole, and insular and posterior cingulate gyri. Linear models including Braak stages, TDP-43 and α-synuclein scores, age, sex, and postmortem interval showed significant correlation between Braak stage and thickness in the parahippocampal gyrus, entorhinal cortex, and Broadman area 35. Conclusion: We demonstrated an association of measures of AD pathology with tissue loss in several AD regions despite a limited range of pathology in these cases. Highlights: Neurodegenerative disorders are associated with co-occurring pathologies that cannot be measured specifically with in vivo methods. Identification of the topographic patterns of these pathologies in structural magnetic resonance imaging (MRI) may provide probabilistic biomarkers. We demonstrated the correlation of the specific patterns of tissue loss from ex vivo brain MRI with underlying pathologies detected in postmortem brain hemispheres in patients with Alzheimer's disease (AD) spectrum disorders. The results provide insight into the interpretation of in vivo structural MRI studies in patients with AD spectrum disorders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- biomarkers
- cortical thickness
- ex vivo MRI
- neurodegeneration
Publication and Content Type
- art (subject category)
- ref (subject category)
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Sadaghiani, Shok ...
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Trotman, Winifre ...
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Lim, Sydney A.
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Chung, Eunice
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Ittyerah, Ranjit
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Ravikumar, Sadha ...
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show more...
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Khandelwal, Pulk ...
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Prabhakaran, Kar ...
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Lavery, Madigan ...
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Ohm, Daniel T.
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Gabrielyan, Mari ...
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Das, Sandhitsu R ...
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Schuck, Theresa
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Capp, Noah
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Peterson, Claire ...
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Migdal, Elyse
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Artacho-Pérula, ...
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Jiménez, María d ...
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Rabal, Maria del ...
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Sánchez, Sandra ...
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Prieto, Carlos d ...
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Parada, Marta Có ...
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Insausti, Ricard ...
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Robinson, John L ...
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McMillan, Corey
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Grossman, Murray
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Lee, Edward B.
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Detre, John A.
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Xie, Sharon X.
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Trojanowski, Joh ...
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Tisdall, M. Dyla ...
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Wisse, Laura E.M ...
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Irwin, David J.
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Wolk, David A.
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Yushkevich, Paul ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's and ...
- By the university
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Lund University