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Interaction Between...
Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload : Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study
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- Thorsen, Steffen U (author)
- University of Copenhagen
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- Liu, Xiang (author)
- University of South Florida
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- Kataria, Yachana (author)
- Boston University
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- Mandrup-Poulsen, Thomas (author)
- University of Copenhagen
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- Kaur, Simranjeet (author)
- Copenhagen University Hospital
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- Uusitalo, Ulla (author)
- University of South Florida
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- Virtanen, Suvi M (author)
- Finnish National Institute for Health and Welfare
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- Norris, Jill M (author)
- University of Colorado at Denver Anschutz Medical Campus
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- Rewers, Marian (author)
- Pacific Northwest Research Institute
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- Hagopian, William (author)
- University of Colorado-Denver
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Yang, Jimin (author)
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She, Jin-Xiong (author)
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Akolkar, Beena (author)
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Rich, Stephen (author)
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- Aronsson, Carin Andrén (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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Ziegler, Anette-Gabriele (author)
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Toppari, Jorma (author)
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Krischer, Jeffrey (author)
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- Parikh, Hemang M (author)
- University of South Florida
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Ellervik, Christina (author)
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Svensson, Jannet (author)
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(creator_code:org_t)
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- 2023-03-03
- 2023
- English.
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In: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 46:5, s. 1014-1018
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Abstract
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- OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.RESULTS: We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.CONCLUSIONS: Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Thorsen, Steffen ...
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Liu, Xiang
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Kataria, Yachana
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Mandrup-Poulsen, ...
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Kaur, Simranjeet
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Uusitalo, Ulla
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show more...
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Virtanen, Suvi M
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Norris, Jill M
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Rewers, Marian
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Hagopian, Willia ...
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Yang, Jimin
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She, Jin-Xiong
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Akolkar, Beena
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Rich, Stephen
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Aronsson, Carin ...
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Lernmark, Åke
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Ziegler, Anette- ...
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Toppari, Jorma
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Krischer, Jeffre ...
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Parikh, Hemang M
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Ellervik, Christ ...
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Svensson, Jannet
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes Care
- By the university
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Lund University