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  • Bhattacharya, RomitHarvard Medical School,Broad Institute,Massachusetts General Hospital (author)

Risk factors for clonal hematopoiesis of indeterminate potential in people with HIV : a report from the REPRIEVE trial

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • 2024
  • 9 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:9a881499-0dd7-4771-90b1-c8af0724eb9b
  • https://lup.lub.lu.se/record/9a881499-0dd7-4771-90b1-c8af0724eb9bURI
  • https://doi.org/10.1182/bloodadvances.2023011324DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Clonal hematopoiesis of indeterminate potential (CHIP), the clonal expansion of myeloid cells with leukemogenic mutations, results in increased coronary artery disease (CAD) risk. CHIP is more prevalent among people with HIV (PWH), but the risk factors are unknown. CHIP was identified among PWH in REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) using whole-exome sequencing. Logistic regression was used to associate sociodemographic factors and HIV-specific factors with CHIP adjusting for age, sex, and smoking status. In the studied global cohort of 4486 PWH, mean age was 49.9 (standard deviation [SD], 6.4) years; 1650 (36.8%) were female; and 3418 (76.2%) were non-White. CHIP was identified in 223 of 4486 (4.97%) and in 38 of 373 (10.2%) among those aged ≥60 years. Age (odds ratio [OR], 1.07; 95% confidence interval [CI], 1.05-1.09; P < .0001) and smoking (OR, 1.37; 95% CI, 1.14-1.66; P < .001) associated with increased odds of CHIP. Globally, participants outside of North America had lower odds of CHIP including sub- Saharan Africa (OR, 0.57; 95% CI, 0.4-0.81; P = .0019), South Asia (OR, 0.45; 95% CI, 0.23-0.80; P = .01), and Latin America/Caribbean (OR, 0.56; 95% CI, 0.34-0.87; P = .014). Hispanic/Latino ethnicity (OR, 0.38; 95% CI, 0.23-0.54; P = .002) associated with significantly lower odds of CHIP. Among HIV-specific factors, CD4 nadir <50 cells/mm3 associated with a 1.9-fold (95% CI, 1.21-3.05; P = .006) increased odds of CHIP, with the effect being significantly stronger among individuals with short duration of antiretroviral therapy (ART; OR, 4.15; 95% CI, 1.51-11.1; P = .005) (Pinteraction= .0492). Among PWH at low-to-moderate CAD risk on stable ART, smoking, CD4 nadir, North American origin, and non-Hispanic ethnicity associated with increased odds of CHIP.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Uddin, Md MesbahBroad Institute (author)
  • Patel, Aniruddh P.Broad Institute,Massachusetts General Hospital,Harvard Medical School (author)
  • Niroula, AbhishekLund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Broad Institute,Dana-Farber Cancer Institute(Swepub:lu)med-anu (author)
  • Finneran, PhoebeMassachusetts General Hospital (author)
  • Bernardo, RachelMassachusetts General Hospital (author)
  • Fitch, Kathleen V.Harvard Medical School,Massachusetts General Hospital (author)
  • Lu, Michael T.Massachusetts General Hospital (author)
  • Bloomfield, Gerald S.Duke Clinical Research Institute (DCRI) (author)
  • Malvestutto, CarlosOhio State University (author)
  • Aberg, Judy A.Icahn School of Medicine at Mount Sinai (author)
  • Fichtenbaum, Carl J.University of Cincinnati College of Medicine (author)
  • Hornsby, WhitneyMassachusetts General Hospital (author)
  • Ribaudo, Heather J. (author)
  • Libby, PeterHarvard Medical School (author)
  • Ebert, Benjamin L.Howard Hughes Medical Institute,Broad Institute,Dana-Farber Cancer Institute,Harvard Medical School (author)
  • Zanni, Markella V.Harvard Medical School,Massachusetts General Hospital (author)
  • Douglas, Pamela S.Duke Clinical Research Institute (DCRI) (author)
  • Grinspoon, Steven K.Harvard Medical School,Massachusetts General Hospital (author)
  • Natarajan, PradeepHarvard Medical School,Massachusetts General Hospital,Broad Institute (author)
  • Harvard Medical SchoolBroad Institute (creator_code:org_t)

Related titles

  • In:Blood Advances8:4, s. 959-9672473-9529

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