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Psychometric Proper...
Psychometric Properties of Clinical Indicators for Identification and Management of Advanced Parkinson’s Disease : Real-World Evidence From G7 Countries
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- Antonini, Angelo (author)
- University of Padova
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- Pahwa, Rajesh (author)
- University of Kansas
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- Odin, Per (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Henriksen, Tove (author)
- Bispebjerg Hospital
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Soileau, Michael J. (author)
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- Rodriguez-Cruz, Ramon (author)
- Synaptic Precision Inc.
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Isaacson, Stuart H. (author)
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- Merola, Aristide (author)
- Ohio State University
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- Lindvall, Susanna (author)
- European Parkinson's Disease Association
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- Domingos, Josefa (author)
- European Parkinson's Disease Association
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- Alobaidi, Ali (author)
- AbbVie Inc.,University of Illinois at Chicago
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- Jalundhwala, Yash J. (author)
- AbbVie Inc.
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- Kandukuri, Prasanna L. (author)
- AbbVie Inc.
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- Parra, Juan Carlos (author)
- AbbVie Inc.
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- Kukreja, Pavnit K. (author)
- AbbVie Inc.
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- Onuk, Koray (author)
- AbbVie Inc.
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- Bergmann, Lars (author)
- AbbVie Inc.
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Pike, James (author)
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- Ray Chaudhuri, K. (author)
- King's College Hospital
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(creator_code:org_t)
- 2022-01-11
- 2022
- English.
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In: Neurology and Therapy. - : Springer Science and Business Media LLC. - 2193-8253 .- 2193-6536. ; 11:1, s. 303-318
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Abstract
Subject headings
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- Introduction: Standardized and validated criteria to define advanced Parkinson’s disease (PD) or identify patient eligibility for device-aided therapy are needed. This study assessed the psychometric properties of clinical indicators of advanced PD and eligibility for device-aided therapy in a large population. Methods: This retrospective analysis of the Adelphi Parkinson’s Disease Specific Programme collected data from device-aided therapy-naïve people with PD in G7 countries. We assessed the presence of 15 clinical indicators of advancing PD and seven indicators of eligibility for device-aided therapy in patients classified with advanced PD or as eligible for device-aided therapy by the treating physician. Accuracy was assessed using area under the curve (AUC) and multivariable logistic regression models. Construct validity was examined via known-group comparisons of disease severity and burden among patients with and without each clinical indicator. Results: Of 4714 PD patients, 14.9% were classified with advanced PD and 17.5% as eligible for device-aided therapy by physician judgment. The presence of each clinical indicator was 1.9- to 7.3-fold more likely in patients classified with advanced PD. Similarly, the presence of device-aided therapy eligibility indicators was 1.8- to 5.5-fold more likely in patients considered eligible for device-aided therapy. All indicators demonstrated high clinical screening accuracy for identifying advanced PD (AUC range 0.84–0.89) and patients eligible for device-aided therapy (AUC range 0.73–0.80). The Unified Parkinson’s Disease Rating Scale (UPDRS) score, cognitive function, quality of life, and caregiver burden were significantly worse in indicator-positive patients. Conclusion: Specific clinical indicators of advanced PD and eligibility for device-aided therapy demonstrated excellent psychometric properties in a large sample, and thus may provide an objective and reliable approach for patient identification and treatment optimization.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Accuracy
- Advanced Parkinson’s disease
- Clinical indicators
- Device-aided therapy eligibility
- Validity
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Antonini, Angelo
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Pahwa, Rajesh
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Odin, Per
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Henriksen, Tove
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Soileau, Michael ...
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Rodriguez-Cruz, ...
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show more...
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Isaacson, Stuart ...
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Merola, Aristide
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Lindvall, Susann ...
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Domingos, Josefa
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Alobaidi, Ali
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Jalundhwala, Yas ...
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Kandukuri, Prasa ...
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Parra, Juan Carl ...
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Kukreja, Pavnit ...
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Onuk, Koray
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Bergmann, Lars
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Pike, James
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Ray Chaudhuri, K ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Neurology and Th ...
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Lund University