id:"swepub:oai:lup.lub.lu.se:9acb6080-4f7d-4ede-b273-2ffbe12d87ce"
Search: id:"swepub:oai:lup.lub.lu.se:9acb6080-4f7d-4ede-b273-2ffbe12d87ce" > Aire-ing self antig...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Holmdahl, RikardLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups (author)
Aire-ing self antigen variability and tolerance.
- Article/chapterEnglish2007
Publisher, publication year, extent ...
- Wiley,2007
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:9acb6080-4f7d-4ede-b273-2ffbe12d87ce
- https://lup.lub.lu.se/record/165419URI
- https://doi.org/10.1002/eji.200737152DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Positional cloning of the underlying genes for the rare syndrome autoimmune polyendocrinopathy candidadiasis extrodermal dystrophy (APECED) opened a new venue of research on the role of central tolerance in autoimmunity. The associated autoimmune regulator gene (AIRE), was found to be expressed in medullary thymus epithelial cells (mTEC) in both man and mice, and to control promiscuous expression of sets of self antigens. The lack of AIRE in both mice and man led to the development of a quite specific, but also an inter-individual variable, set of autoimmune and infectious diseases. An article in this issue of the European Journal of Immunology demonstrates that several autoantigens controlled by AIRE are variably expressed in different human individuals. Most importantly it is shown that carriers of the type 1 diabetes (T1D) associated locus IDDM2 show lower expression of insulin in mTEC, as controlled by AIRE. The genetic variability of autoantigen expression in the thymus thus seems to determine the variable predisposition to autoimmunity.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
- medullary thymic epithelial cells
- AIRE
- diabetes
- insulin
Added entries (persons, corporate bodies, meetings, titles ...)
- ImmunologiForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:European Journal of Immunology: Wiley37:3, s. 598-6011521-41410014-2980
Internet link
Find in a library
- European Journal of Immunology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Holmdahl, Rikard
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Immunology in th ...
- Articles in the publication
- European Journal ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
