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Life-long impairmen...
Life-long impairment of glucose homeostasis upon prenatal exposure to psychostimulants
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- Korchynska, Solomiia (author)
- Medical University of Vienna
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- Krassnitzer, Maria (author)
- Medical University of Vienna
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- Malenczyk, Katarzyna (author)
- Medical University of Vienna
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- Prasad, Rashmi B (author)
- Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital
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- Tretiakov, Evgenii O (author)
- Medical University of Vienna
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- Rehman, Sabah (author)
- Medical University of Vienna
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- Cinquina, Valentina (author)
- Medical University of Vienna
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- Gernedl, Victoria (author)
- CeMM Research Center for Molecular Medicine
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- Farlik, Matthias (author)
- CeMM Research Center for Molecular Medicine
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- Petersen, Julian (author)
- Medical University of Vienna
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- Hannes, Sophia (author)
- Medical University of Vienna
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- Schachenhofer, Julia (author)
- Medical University of Vienna
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Reisinger, Sonali N (author)
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- Zambon, Alice (author)
- Medical University of Vienna
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- Asplund, Olof (author)
- Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Artner, Isabella (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Endokrin Celldifferentiering,Forskargrupper vid Lunds universitet,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Endocrine Cell Differentiation and Function,Lund University Research Groups
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Keimpema, Erik (author)
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- Lubec, Gert (author)
- Paracelsus Private Medical University of Salzburg
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- Mulder, Jan (author)
- Karolinska Institutet,Karolinska Institute
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Bock, Christoph (author)
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Pollak, Daniela D (author)
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Romanov, Roman A (author)
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Pifl, Christian (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital
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- Hökfelt, Tomas Gm (author)
- Karolinska Institute
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- Harkany, Tibor (author)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- 2019-11-21
- 2020
- English.
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In: EMBO Journal. - : EMBO. - 1460-2075 .- 0261-4189. ; 39:1
- Related links:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Maternal drug abuse during pregnancy is a rapidly escalating societal problem. Psychostimulants, including amphetamine, cocaine, and methamphetamine, are amongst the illicit drugs most commonly consumed by pregnant women. Neuropharmacology concepts posit that psychostimulants affect monoamine signaling in the nervous system by their affinities to neurotransmitter reuptake and vesicular transporters to heighten neurotransmitter availability extracellularly. Exacerbated dopamine signaling is particularly considered as a key determinant of psychostimulant action. Much less is known about possible adverse effects of these drugs on peripheral organs, and if in utero exposure induces lifelong pathologies. Here, we addressed this question by combining human RNA-seq data with cellular and mouse models of neuroendocrine development. We show that episodic maternal exposure to psychostimulants during pregnancy coincident with the intrauterine specification of pancreatic β cells permanently impairs their ability of insulin production, leading to glucose intolerance in adult female but not male offspring. We link psychostimulant action specifically to serotonin signaling and implicate the sex-specific epigenetic reprogramming of serotonin-related gene regulatory networks upstream from the transcription factor Pet1/Fev as determinants of reduced insulin production.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Korchynska, Solo ...
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Krassnitzer, Mar ...
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Malenczyk, Katar ...
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Prasad, Rashmi B
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Tretiakov, Evgen ...
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Rehman, Sabah
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show more...
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Cinquina, Valent ...
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Gernedl, Victori ...
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Farlik, Matthias
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Petersen, Julian
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Hannes, Sophia
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Schachenhofer, J ...
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Reisinger, Sonal ...
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Zambon, Alice
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Asplund, Olof
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Artner, Isabella
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Keimpema, Erik
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Lubec, Gert
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Mulder, Jan
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Bock, Christoph
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Pollak, Daniela ...
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Romanov, Roman A
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Pifl, Christian
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Groop, Leif
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Hökfelt, Tomas G ...
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Harkany, Tibor
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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EMBO Journal
- By the university
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Lund University
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Karolinska Institutet