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Inflammation-associ...
Inflammation-associated graft loss in renal transplant recipients
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Dahle, Dag Olav (author)
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Mjoen, Geir (author)
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- Öqvist, Björn (author)
- Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Scharnagl, Hubert (author)
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Weihrauch, Gisela (author)
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Grammer, Tanja (author)
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Maerz, Winfried (author)
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Abedini, Sadollah (author)
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Norby, Gudrun E. (author)
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Holme, Ingar (author)
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- Fellström, Bengt (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Jardine, Alan (author)
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Holdaas, Hallvard (author)
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(creator_code:org_t)
- 2011-04-21
- 2011
- English.
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In: Nephrology Dialysis Transplantation. - : Oxford University Press (OUP). - 1460-2385 .- 0931-0509. ; 26:11, s. 3756-3761
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Abstract
Subject headings
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- Background. Although short-term graft survival has improved substantially in renal transplant recipients, long-term graft survival has not improved over the last decades. The lack of knowledge of specific causes and risk factors has hampered improvements in long-term allograft survival. There is an uncertainty if inflammation is associated with late graft loss. Methods. We examined, in a large prospective trial, the inflammation markers high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) and their association with chronic graft dysfunction. We collected data from the Assessment of Lescol in Renal Transplant trial, which recruited 2102 maintenance renal transplant recipients. Results. Baseline values were hsCRP 3.8 +/- 6.7 mg/L and IL-6 2.9 +/- 1.9 pg/mL. Adjusted for traditional risk factors, hsCRP and IL-6 were independently associated with death-censored graft loss, the composite end points graft loss or death and doubling of serum creatinine, graft loss or death. Conclusion. The inflammation markers hsCRP and IL-6 are associated with long-term graft outcomes in renal transplant recipients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- ALERT
- high-sensitivity CRP
- inflammation
- interleukin-6
- renal
- allograft survival
- ALERT
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Dahle, Dag Olav
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Mjoen, Geir
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Öqvist, Björn
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Scharnagl, Huber ...
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Weihrauch, Gisel ...
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Grammer, Tanja
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show more...
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Maerz, Winfried
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Abedini, Sadolla ...
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Norby, Gudrun E.
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Holme, Ingar
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Fellström, Bengt
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Jardine, Alan
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Holdaas, Hallvar ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Nephrology Dialy ...
- By the university
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Lund University
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Uppsala University