Tissue proteome profiling of preeclamptic placenta using recombinant antibody microarrays

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: id:"swepub:oai:lup.lub.lu.se:9b696e41-d6b5-42d0-ba93-f683ab2837be" > Tissue proteome pro...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Dexlin Mellby, LindaLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH (author)

Tissue proteome profiling of preeclamptic placenta using recombinant antibody microarrays

Article/chapterEnglish2010

Publisher, publication year, extent ...

2010-10-04
Wiley,2010
14 s.

Numbers

LIBRIS-ID:oai:lup.lub.lu.se:9b696e41-d6b5-42d0-ba93-f683ab2837be
https://lup.lub.lu.se/record/1752759URI
https://doi.org/10.1002/prca.201000001DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

PURPOSE: preeclampsia (PE) is a severe, multi-system pregnancy disorder of yet unknown cause, missing means of treatment, and our fundamental understanding of the disease is still impaired. The purpose of this discovery study was to define candidate placenta tissue protein biomarker signatures to further decipher the molecular features of PE.EXPERIMENTAL DESIGN: we used recombinant antibody microarrays for multiplexed protein expression profiling of preeclamptic placenta tissue (n=25) versus normal placenta (n=11) targeting mainly immunoregulatory water-soluble proteins and membrane proteins. Furthermore, the three known subgroups of PE were profiled, including women with early onset preeclampsia and late onset preeclampsia, as well as women with PE and bilateral notching and intrauterine growth restrictions.RESULTS: the data showed that the first generation of candidate PE-associated placenta tissue protein signatures were delineated, indicating that PE (receiver operating characteristics (ROC) AUC value of 0.83) and the subgroups thereof (ROC AUC values ≤ 0.91) could be distinguished. Notably, the data implied that all subgroups, but preeclampsia with bilateral notching and IUGR, could be further classified into novel subsets (ROC AUC values of 1.0) displaying different inflammatory signatures.CONCLUSIONS AND CLINICAL RELEVANCE: we have taken one step further toward de-convoluting the complex features of PE at the molecular level using affinity proteomics.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
Adult
Female
Gene Expression Profiling/methods
Gestational Age
Humans
Middle Aged
Placenta/metabolism
Pre-Eclampsia/genetics
Pregnancy
Protein Array Analysis/methods
Proteome/analysis
Recombinant Proteins/genetics
Young Adult

Added entries (persons, corporate bodies, meetings, titles ...)

Sandström Gerdtsson, AnnaLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)an1350sa (author)
Centlow, MagnusLund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)gyn-mce (author)
Sjögren, SaraLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)immu-srn (author)
Hansson, StefanLund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)gyn-sha (author)
Borrebaeck, CarlLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)immt-cbo (author)
Wingren, ChristerLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)immt-cwi (author)
Institutionen för immunteknologiInstitutioner vid LTH (creator_code:org_t)

Related titles

In:Proteomics Clinical Applications: Wiley4:10-11, s. 794-8071862-83541862-8346

Internet link

Find in a library

Proteomics Clinical Applications (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Dexlin Mellby, L ...; Sandström Gerdts ...; Centlow, Magnus; Sjögren, Sara; Hansson, Stefan; Borrebaeck, Carl; show more...; Wingren, Christe ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

Articles in the publication: Proteomics Clini ...

By the university: Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se