Expression and motor effects of secretin in small and large intestine of the rat

Sökning: L773:0196 9781 > Expression and moto...

Andersson, AmelieLund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups (författare)

Immunocytochemistry and in situ hybridization revealed abundant secretin expressing cells on duodenal villi with a gradual decrease throughout the small intestines of the rat. They were absent in pancreas, stomach and colon. Secretin caused relaxation of rat intestinal longitudinal muscle in vitro. Studies on colon revealed that the secretin-evoked response was unaffected by apamin, tetrodotoxin, L-NAME, VIP or PACAP pretreatment; secretin itself caused desensitization. Addition of VIP or PACAP when the secretin-evoked relaxation was maximal evoked a further relaxation suggesting the presence of distinct receptors. Secretin causes relaxation via activation of secretin receptors located on the smooth muscle and not via any of the related VIP/PACAP receptors.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Acetylcholine/pharmacology
Animals
Apamin/pharmacology
Colon/drug effects
Dose-Response Relationship, Drug
Female
Ganglia/metabolism
Gastric Mucosa/metabolism
Ileum/drug effects
Immunohistochemistry
In Situ Hybridization
Intestine, Large/drug effects
Intestine, Small/drug effects
Muscle, Smooth/drug effects
NG-Nitroarginine Methyl Ester/pharmacology
Neuropeptides/pharmacology
Neurotransmitter Agents/pharmacology
Pancreas/metabolism
Pituitary Adenylate Cyclase-Activating Polypeptide
Rats
Rats, Sprague-Dawley
Secretin/biosynthesis
Tetrodotoxin/pharmacology
Vasoactive Intestinal Peptide/pharmacology

Sundler, FrankLund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups(Swepub:lu)mphy-fsu (författare)
Ekblad, EvaLund University,Lunds universitet,Neurogastroenterologi,Forskargrupper vid Lunds universitet,Neurogastroenterology,Lund University Research Groups(Swepub:lu)mphy-eek (författare)
Neuroendokrin cellbiologiForskargrupper vid Lunds universitet (creator_code:org_t)

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

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