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Intrathecally appli...
Intrathecally applied morphine inhibits nociceptive C fiber input to the primary somatosensory cortex (SI) of the rat
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- Kalliomäki, Jarkko (författare)
- Skåne University Hospital
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- Luo, Xiao Ling (författare)
- Skåne University Hospital
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- Yu, Yong Bei (författare)
- Skåne University Hospital
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- Schouenborg, Jens (författare)
- Lund University,Lunds universitet,Neuronano Research Center (NRC),Forskargrupper vid Lunds universitet,Lund University Research Groups
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(creator_code:org_t)
- 1998
- 1998
- Engelska.
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Ingår i: Pain. - 0304-3959. ; 77:3, s. 323-329
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Nociceptive C fiber input to SI in the halothane-nitrous oxide anesthetized rat was assessed by recording cortical field potentials evoked by noxious thermal cutaneous stimulation with CO2-laser pulses. Morphine topically applied onto the lumbar spinal cord produced a dose-dependent inhibition of nociceptive C fiber input from the hind paw to the contralateral SI. The inhibitory effect of morphine was reversed by naloxone. Potentials evoked by CO2-laser stimulation of the forepaw were unaffected by morphine applied on the lumbar cord, indicating that the effect of morphine was exerted at the segmental level. It is concluded that input from nociceptive C fibers to SI is relayed in the spinal cord and can be inhibited by spinal opioid receptor activation. The present method offers an interesting model of ascending nociceptive transmission to the cerebral cortex. Copyright (C) 1998 International Association for the Study of Pain. Published by Elsevier Science B.V.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Analgesia
- Cerebral cortex
- Evoked potential
- Opioids
- Pain
- Somatosensory pathways
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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