Cancer risks associated with germline PALB2 pathogenic variants : An international study of 524 families

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Search: WFRF:(Concannon Patrick) > Domchek Susan M. > Cancer risks associ...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Yang, XinUniversity of Cambridge (author)

Cancer risks associated with germline PALB2 pathogenic variants : An international study of 524 families

Article/chapterEnglish2020

Publisher, publication year, extent ...

2020

Numbers

LIBRIS-ID:oai:lup.lub.lu.se:9c2cb720-8f1e-451d-a459-53260d1bafbb
https://lup.lub.lu.se/record/9c2cb720-8f1e-451d-a459-53260d1bafbbURI
https://doi.org/10.1200/JCO.19.01907DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

PURPOSE To estimate age-specific relative and absolute cancer risks of breast cancer and to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers associated with germline PALB2 pathogenic variants (PVs) because these risks have not been extensively characterized. METHODS We analyzed data from 524 families with PALB2 PVs from 21 countries. Complex segregation analysis was used to estimate relative risks (RRs; relative to country-specific population incidences) and absolute risks of cancers. The models allowed for residual familial aggregation of breast and ovarian cancer and were adjusted for the family-specific ascertainment schemes. RESULTS We found associations between PALB2 PVs and risk of female breast cancer (RR, 7.18; 95% CI, 5.82 to 8.85; P = 6.5 × 10-76), ovarian cancer (RR, 2.91; 95% CI, 1.40 to 6.04; P = 4.1 × 10-3), pancreatic cancer (RR, 2.37; 95% CI, 1.24 to 4.50; P = 8.7 × 10-3), and male breast cancer (RR, 7.34; 95% CI, 1.28 to 42.18; P = 2.6 3 1022). There was no evidence for increased risks of prostate or colorectal cancer. The breast cancer RRs declined with age (P for trend = 2.0 × 10-3). After adjusting for family ascertainment, breast cancer risk estimates on the basis of multiple case families were similar to the estimates from families ascertained through population-based studies (P for difference = .41). On the basis of the combined data, the estimated risks to age 80 years were 53% (95% CI, 44% to 63%) for female breast cancer, 5% (95% CI, 2% to 10%) for ovarian cancer, 2%-3% (95% CI females, 1% to 4%; 95% CI males, 2% to 5%) for pancreatic cancer, and 1% (95% CI, 0.2% to 5%) for male breast cancer. CONCLUSION These results confirm PALB2 as a major breast cancer susceptibility gene and establish substantial associations between germline PALB2 PVs and ovarian, pancreatic, and male breast cancers. These findings will facilitate incorporation of PALB2 into risk prediction models and optimize the clinical cancer risk management of PALB2 PV carriers.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

Leslie, GoskaUniversity of Cambridge (author)
Doroszuk, AlicjaUniversity of Cambridge (author)
Schneider, SandraUniversity of Cambridge (author)
Allen, JamieUniversity of Cambridge (author)
Decker, BrennanNational Human Genome Research Institute,University of Cambridge,Brigham and Women's Hospital / Harvard Medical School (author)
Dunning, Alison M.University of Cambridge (author)
Redman, JamesUniversity of Cambridge (author)
Scarth, JamesUniversity of Cambridge (author)
Plaskocinska, IngaUniversity of Cambridge (author)
Luccarini, CraigUniversity of Cambridge (author)
Shah, MitulUniversity of Cambridge (author)
Pooley, KarenUniversity of Cambridge (author)
Dorling, LeilaUniversity of Cambridge (author)
Leei, AndrewUniversity of Cambridge (author)
Adank, Muriel A.Antoni Van Leeuwenhoek Hospital (author)
Adlard, JulianChapel Allerton Hospital (author)
Aittomäki, KristiinaHelsinki University Central Hospital (author)
Andrulis, Irene L.Mount Sinai Hospital of University of Toronto (author)
Ang, PeterNational Cancer Centre Singapore (author)
Barwell, JulianUniversity Hospitals of Leicester NHS Trust (author)
Bernstein, Jonine L.Memorial Sloan-Kettering Cancer Center (author)
Bobolis, KristieClinical Cancer Genomics Community Research Network (author)
Borg, ÅkeLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-abo (author)
Blomqvist, CarlHelsinki University Central Hospital (author)
Claes, Kathleen B.M.Ghent University Hospital (author)
Concannon, PatrickUniversity of Florida (author)
Cuggia, AdelineMcGill University (author)
Culver, Julie O.University of Southern California (author)
Damiola, FrancescaCentre Léon Bérard (author)
De Pauw, AntoineCurie Institute, Paris (author)
Diez, OrlandVall d’Hebron Institute of Oncology (author)
Dolinsky, Jill S.Ambry Genetics Corporation (author)
Domchek, Susan M.University of Pennsylvania,Prospective registry of multiplex testing (PROMPT) (author)
Engel, ChristophLeipzig University (author)
Evans, D. GarethUniversity of Manchester (author)
Fostira, FlorentiaNational Centre for Scientific Research Demokritos (author)
Garber, JudyDana-Farber Cancer Institute,Prospective registry of multiplex testing (PROMPT) (author)
Golmard, LisaCurie Institute, Paris (author)
Goode, Ellen L.Mayo Clinic Minnesota (author)
Gruber, Stephen B.Beckman Research Institute of City of Hope (author)
Hahnen, EricUniversity of Cologne,University Hospital of Cologne (author)
Hake, ChristopherClinical Cancer Genomics Community Research Network (author)
Heikkinen, TuomasHelsinki University Central Hospital (author)
Hurley, Judith E.University of Miami (author)
Janavicius, RamunasVilnius University Hospital,State Research Institute Innovative Medicine Center (author)
Kleibl, ZdenekGeneral University Hospital in Prague (author)
Kleiblova, PetraGeneral University Hospital in Prague,Charles University in Prague (author)
Konstantopoulou, IreneNational Centre for Scientific Research Demokritos (author)
Kvist, AndersLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)ekol-akv (author)
Laduca, HollyAmbry Genetics Corporation (author)
Lee, Ann S.G.University Hospitals of Leicester NHS Trust,National University of Singapore,Duke–NUS Medical School (author)
Lesueur, FabiennePSL University (author)
Maher, Eamonn R.University of Cambridge (author)
Mannermaa, ArtoUniversity of Eastern Finland (author)
Manoukian, SiranoushIstituto Nazionale dei Tumori (author)
McFarland, RachelAmbry Genetics Corporation,University of California, Irvine (author)
McKinnon, WendyUniversity of Vermont (author)
Meindl, AlfonsLudwig-Maximilian University of Munich (author)
Metcalfe, KellyUniversity of Toronto (author)
Taib, Nur Aishah MohdUniversity of Malaya (author)
Moilanen, JukkaOulu University Hospital (author)
Nathanson, Katherine L.University of Pennsylvania (author)
Neuhausen, SusanBeckman Research Institute of City of Hope (author)
Ng, Pei SzeCancer Research Initiatives Foundation,University of Malaya (author)
Nguyen-Dumont, TuMonash University,University of Melbourne (author)
Nielsen, Sarah M.University of Chicago (author)
Obermair, FlorianKepler University Hospital Linz (author)
Offit, KennethMemorial Sloan-Kettering Cancer Center (author)
Olopade, Olufunmilayo I.University of Chicago (author)
Ottini, LauraSapienza University of Rome (author)
Penkert, JudithHannover Medical School (author)
Pylkäs, KatriUniversity of Oulu (author)
Goldgar, DavidIstituto Nazionale dei Tumori (author)
Ramus, Susan J.University of New South Wales,Garvan Institute of Medical Research (author)
Rudaitis, ViliusVilnius University Hospital (author)
Side, LucyPrincess Anne Hospital (author)
Silva-Smith, RachelUniversity of Miami (author)
Silvestri, ValentinaSapienza University of Rome (author)
Skytte, Anne BineAarhus University Hospital (author)
Slavin, ThomasClinical Cancer Genomics Community Research Network,Beckman Research Institute of City of Hope (author)
Soukupova, JanaGeneral University Hospital in Prague (author)
Tondini, CarloPapa Giovanni XXIII Hospital (author)
Trainer, Alison H.Peter MacCallum Cancer Centre,University of Melbourne (author)
Unzeitig, GaryClinical Cancer Genomics Community Research Network (author)
Usha, LydiaClinical Cancer Genomics Community Research Network (author)
Van Overeem Hansen, ThomasCopenhagen University Hospital (author)
Whitworth, JamesUniversity of Cambridge (author)
Wood, MarieUniversity of Vermont (author)
Yip, Cheng HarCancer Research Initiatives Foundation (author)
Yoon, Sook YeeCancer Research Initiatives Foundation (author)
Yussuf, AmalAmbry Genetics Corporation (author)
Zogopoulos, GeorgeMcGill University (author)
Radice, PaoloHuntsman Cancer Institute (author)
Hopper, John L.University of Melbourne (author)
Chenevix-Trench, GeorgiaQIMR Berghofer Medical Research Institute (author)
Pharoah, PaulUniversity of Cambridge (author)
George, Sophia H.L.University of Miami (author)
Balmaña, JudithProspective registry of multiplex testing (PROMPT),Vall d’Hebron Institute of Oncology (author)
Houdayer, ClaudeRouen University Hospital,Curie Institute, Paris (author)
James, PaulUniversity of Melbourne,Peter MacCallum Cancer Centre (author)
El-Haffaf, ZakiUniversity Of Montreal Health Center (CRCHUM) (author)
Ehrencrona, HansLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)med-hen (author)
Janatova, MarketaGeneral University Hospital in Prague (author)
Peterlongo, PaoloIFOM - The FIRC Institute of Molecular Oncology (author)
Nevanlinna, HeliHelsinki University Central Hospital (author)
Schmutzler, RitaUniversity Hospital of Cologne,University of Cologne (author)
Teo, Soo HwangCancer Research Initiatives Foundation,University of Malaya (author)
Robson, MarkMemorial Sloan-Kettering Cancer Center,Prospective registry of multiplex testing (PROMPT) (author)
Pal, TuyaVanderbilt University (author)
Couch, FergusMayo Clinic Minnesota (author)
Weitzel, Jeffrey N.Clinical Cancer Genomics Community Research Network,Beckman Research Institute of City of Hope (author)
Elliott, AaronAmbry Genetics Corporation (author)
Southey, MelissaMonash University,University of Melbourne (author)
Winqvist, RobertUniversity of Oulu (author)
Easton, Douglas F.University of Cambridge (author)
Foulkes, William D.McGill University (author)
Antoniou, Antonis C.University of Cambridge (author)
Tischkowitz, MarcUniversity of Cambridge (author)
University of CambridgeNational Human Genome Research Institute (creator_code:org_t)

Related titles

In:Journal of Clinical Oncology38:7, s. 674-6850732-183X

Internet link

Find in a library

Journal of Clinical Oncology (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Yang, Xin; Leslie, Goska; Doroszuk, Alicja; Schneider, Sandr ...; Allen, Jamie; Decker, Brennan; show more...; Dunning, Alison ...; Redman, James; Scarth, James; Plaskocinska, In ...; Luccarini, Craig; Shah, Mitul; Pooley, Karen; Dorling, Leila; Leei, Andrew; Adank, Muriel A.; Adlard, Julian; Aittomäki, Krist ...; Andrulis, Irene ...; Ang, Peter; Barwell, Julian; Bernstein, Jonin ...; Bobolis, Kristie; Borg, Åke; Blomqvist, Carl; Claes, Kathleen ...; Concannon, Patri ...; Cuggia, Adeline; Culver, Julie O.; Damiola, Frances ...; De Pauw, Antoine; Diez, Orland; Dolinsky, Jill S ...; Domchek, Susan M ...; Engel, Christoph; Evans, D. Gareth; Fostira, Florent ...; Garber, Judy; Golmard, Lisa; Goode, Ellen L.; Gruber, Stephen ...; Hahnen, Eric; Hake, Christophe ...; Heikkinen, Tuoma ...; Hurley, Judith E ...; Janavicius, Ramu ...; Kleibl, Zdenek; Kleiblova, Petra; Konstantopoulou, ...; Kvist, Anders; Laduca, Holly; Lee, Ann S.G.; Lesueur, Fabienn ...; Maher, Eamonn R.; Mannermaa, Arto; Manoukian, Siran ...; McFarland, Rache ...; McKinnon, Wendy; Meindl, Alfons; Metcalfe, Kelly; Taib, Nur Aishah ...; Moilanen, Jukka; Nathanson, Kathe ...; Neuhausen, Susan; Ng, Pei Sze; Nguyen-Dumont, T ...; Nielsen, Sarah M ...; Obermair, Floria ...; Offit, Kenneth; Olopade, Olufunm ...; Ottini, Laura; Penkert, Judith; Pylkäs, Katri; Goldgar, David; Ramus, Susan J.; Rudaitis, Vilius; Side, Lucy; Silva-Smith, Rac ...; Silvestri, Valen ...; Skytte, Anne Bin ...; Slavin, Thomas; Soukupova, Jana; Tondini, Carlo; Trainer, Alison ...; Unzeitig, Gary; Usha, Lydia; Van Overeem Hans ...; Whitworth, James; Wood, Marie; Yip, Cheng Har; Yoon, Sook Yee; Yussuf, Amal; Zogopoulos, Geor ...; Radice, Paolo; Hopper, John L.; Chenevix-Trench, ...; Pharoah, Paul; George, Sophia H ...; Balmaña, Judith; Houdayer, Claude; James, Paul; El-Haffaf, Zaki; Ehrencrona, Hans; Janatova, Market ...; Peterlongo, Paol ...; Nevanlinna, Heli; Schmutzler, Rita; Teo, Soo Hwang; Robson, Mark; Pal, Tuya; Couch, Fergus; Weitzel, Jeffrey ...; Elliott, Aaron; Southey, Melissa; Winqvist, Robert; Easton, Douglas ...; Foulkes, William ...; Antoniou, Antoni ...; Tischkowitz, Mar ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: Journal of Clini ...

By the university: Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se