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IgG Fc sialylation ...
IgG Fc sialylation is regulated during the germinal center reaction upon immunization with different adjuvants
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- Bartsch, Yannic C (author)
- University of Lübeck
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- Eschweiler, Simon (author)
- University of Lübeck
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- Leliavski, Alexei (author)
- University of Lübeck
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- Lunding, Hanna B (author)
- University of Lübeck
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- Wagt, Sander (author)
- University of Lübeck,Leiden University Medical Centre
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- Petry, Janina (author)
- University of Lübeck
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- Lilienthal, Gina-Maria (author)
- University of Lübeck
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- Rahmöller, Johann (author)
- University of Lübeck,University Medical Center Schleswig-Holstein
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- de Haan, Noortje (author)
- Leiden University Medical Centre
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- Hölscher, Alexandra (author)
- Research Center Borstel
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- Erapaneedi, Raghu (author)
- University Hospital of Wϋrzburg
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- Giannou, Anastasios D (author)
- University Medical Center Hamburg-Eppendorf
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- Aly, Lilian (author)
- Technical University of Munich
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- Sato, Ryota (author)
- RIKEN Center for Integrative Medical Sciences
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- de Neef, Louise A (author)
- Leiden University Medical Centre
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- Winkler, André (author)
- University of Lübeck
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- Braumann, Dominique (author)
- University of Lübeck
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- Hobusch, Juliane (author)
- University of Lübeck
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- Kuhnigk, Kyra (author)
- University of Lübeck
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- Krémer, Vanessa (author)
- University of Lübeck
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- Steinhaus, Moritz (author)
- University of Lübeck
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- Blanchard, Véronique (author)
- Charité - University Medicine Berlin
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- Gemoll, Timo (author)
- University of Lübeck
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- Habermann, Jens K (author)
- University of Lübeck
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- Collin, Mattias (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infektion och immunmodulering,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Infection and immunomodulation,Lund University Research Groups
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- Salinas, Gabriela (author)
- University Medical Center Göttingen
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- Manz, Rudolf A (author)
- University of Lübeck
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- Fukuyama, Hidehiro (author)
- RIKEN Center for Integrative Medical Sciences
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- Korn, Thomas (author)
- Technical University of Munich
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- Waisman, Ari (author)
- Johannes-Gutenberg University Mainz
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- Yogev, Nir (author)
- University Hospital of Cologne
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- Huber, Samuel (author)
- University Medical Center Hamburg-Eppendorf
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- Rabe, Björn (author)
- University of Kiel
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- Rose-John, Stefan (author)
- University of Kiel
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- Busch, Hauke (author)
- University of Lübeck
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- Berberich-Siebelt, Friederike (author)
- Julius Maximilian University of Würzburg
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- Hölscher, Christoph (author)
- Research Center Borstel
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- Wuhrer, Manfred (author)
- Leiden University
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- Ehlers, Marc (author)
- University of Lübeck,German Center for Lung Research (DZL),German Research Centre for Rheumatology, Berlin
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English 15 s.
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In: The Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 146:3, s. 652-666
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Abstract
Subject headings
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- BACKGROUND: Effector functions of IgG antibodies (Abs) are regulated by their Fc N-glycosylation pattern. IgG Fc glycans that lack galactose and terminal sialic acid residues correlate with the severity of inflammatory (auto)immune disorders and have also been linked to the protection against viral infection and discussed in the context of vaccine-induced protection. In contrast, sialylated IgG Abs have shown immunosuppressive effects.OBJECTIVE: We sought to investigate IgG glycosylation programming during the germinal center (GC) reaction upon immunization of mice with a foreign protein antigen and different adjuvants.METHODS: Mice were analyzed for GC T, B cell and plasma cell responses as well as antigen-specific serum IgG subclass titers and Fc glycosylation patterns.RESULTS: Different adjuvants induce distinct IgG+ GC B cell responses with specific transcriptomes and expression levels of the α2,6-sialyltransferase responsible for IgG sialylation that correspond to distinct serum IgG Fc glycosylation patterns. Low IgG Fc sialylation programming in GC B cells was overall highly dependent on the T follicular helper (TFH) cell-inducing cytokine IL-6, especially induced by water-in-oil adjuvants and Mycobacterium tuberculosis (Mtb). Furthermore, low IgG Fc sialylation programming was dependent on adjuvants that induced IL-27R-dependent IFNγ+ TFH1 cells, IL-6/IL-23-dependent IL-17A+ TFH17 cells and high TFH/T follicular regulatory (TFR) cell ratios. The two latter were here dependent on Mtb and its cord factor.CONCLUSION: These findings on adjuvant-dependent GC responses and IgG glycosylation programming may aid the development of novel vaccination strategies to induce IgG Abs with both high affinity and defined Fc glycosylation patterns.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Bartsch, Yannic ...
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Eschweiler, Simo ...
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Leliavski, Alexe ...
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Lunding, Hanna B
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Wagt, Sander
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Petry, Janina
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show more...
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Lilienthal, Gina ...
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Rahmöller, Johan ...
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de Haan, Noortje
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Hölscher, Alexan ...
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Erapaneedi, Ragh ...
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Giannou, Anastas ...
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Aly, Lilian
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Sato, Ryota
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de Neef, Louise ...
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Winkler, André
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Braumann, Domini ...
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Hobusch, Juliane
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Kuhnigk, Kyra
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Krémer, Vanessa
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Steinhaus, Morit ...
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Blanchard, Véron ...
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Gemoll, Timo
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Habermann, Jens ...
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Collin, Mattias
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Salinas, Gabriel ...
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Manz, Rudolf A
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Fukuyama, Hidehi ...
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Korn, Thomas
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Waisman, Ari
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Yogev, Nir
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Huber, Samuel
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Rabe, Björn
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Rose-John, Stefa ...
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Busch, Hauke
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Berberich-Siebel ...
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Hölscher, Christ ...
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Wuhrer, Manfred
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Ehlers, Marc
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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MEDICAL AND HEAL ...
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and Infectious Medic ...
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