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  • Kemppainen, Kaisa MUniversity of Florida (författare)

Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • American Medical Association (AMA),2017
  • 9 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:9d6b780f-6cb0-4264-b457-1ddf41166622
  • https://lup.lub.lu.se/record/9d6b780f-6cb0-4264-b457-1ddf41166622URI
  • https://doi.org/10.1001/jamapediatrics.2017.2905DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Importance: Evidence is lacking regarding the consequences of antibiotic use in early life and the risk of certain autoimmune diseases.Objective: To test the association between early-life antibiotic use and islet or celiac disease (CD) autoimmunity in genetically at-risk children prospectively followed up for type 1 diabetes (T1D) or CD.Design, Setting, and Participants: HLA-genotyped newborns from Finland, Germany, Sweden, and the United States were enrolled in the prospective birth cohort of The Environmental Determinants of Diabetes in the Young (TEDDY) study between November 20, 2004, and July 8, 2010. The dates of analysis were November 20, 2004, to August 31, 2014. Individuals from the general population and those having a first-degree relative with T1D were enrolled if they had 1 of 9 HLA genotypes associated with a risk for T1D.Exposures: Parental reports of the most common antibiotics (cephalosporins, penicillins, and macrolides) used between age 3 months and age 4 years were recorded prospectively.Main Outcomes and Measures: Islet autoimmunity and CD autoimmunity were defined as being positive for islet or tissue transglutaminase autoantibodies at 2 consecutive clinic visits at least 3 months apart. Hazard ratios and 95% CIs calculated from Cox proportional hazards regression models were used to assess the relationship between antibiotic use in early life before seroconversion and the development of autoimmunity.Results: Participants were 8495 children (49.0% female) and 6558 children (48.7% female) enrolled in the TEDDY study who were tested for islet and tissue transglutaminase autoantibodies, respectively. Exposure to and frequency of use of any antibiotic assessed in this study in early life or before seroconversion did not influence the risk of developing islet autoimmunity or CD autoimmunity. Cumulative use of any antibiotic during the first 4 years of life was not associated with the appearance of any autoantibody (hazard ratio [HR], 0.98; 95% CI, 0.95-1.01), multiple islet autoantibodies (HR, 0.99; 95% CI, 0.95-1.03), or the transglutaminase autoantibody (HR, 1.00; 95% CI, 0.98-1.02).Conclusions and Relevance: The use of the most prescribed antibiotics during the first 4 years of life, regardless of geographic region, was not associated with the development of autoimmunity for T1D or CD. These results suggest that a risk of islet or tissue transglutaminase autoimmunity need not influence the recommendations for clinical use of antibiotics in young children at risk for T1D or CD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Vehik, KendraUniversity of South Florida(Swepub:lu)med-krv (författare)
  • Lynch, Kristian FUniversity of South Florida(Swepub:lu)kr7183ly (författare)
  • Larsson, Helena EldingLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-hla (författare)
  • Canepa, Ronald JUniversity of Florida (författare)
  • Simell, VilleUniversity of Turku (författare)
  • Koletzko, SibylleLudwig-Maximilian University of Munich (författare)
  • Liu, EdwinUniversity of Colorado-Denver (författare)
  • Simell, Olli GUniversity of Turku (författare)
  • Toppari, JormaUniversity of Turku (författare)
  • Ziegler, Anette GTechnical University of Munich (författare)
  • Rewers, Marian J (författare)
  • Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-ale (författare)
  • Hagopian, William A (författare)
  • She, Jin-Xiong (författare)
  • Akolkar, Beena (författare)
  • Schatz, Desmond A (författare)
  • Atkinson, Mark A (författare)
  • Blaser, Martin J (författare)
  • Krischer, Jeffrey P (författare)
  • Hyöty, Heikki (författare)
  • Agardh, DanielLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-dia (författare)
  • Triplett, Eric W (författare)
  • University of FloridaUniversity of South Florida (creator_code:org_t)
  • TEDDY Study Group

Sammanhörande titlar

  • Ingår i:JAMA Pediatrics: American Medical Association (AMA)171:12, s. 1217-12252168-62112168-6203

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