CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression : A study of fully automated immunoassays in BioFINDER and ADNI cohorts

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Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital (author)

CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression : A study of fully automated immunoassays in BioFINDER and ADNI cohorts

Article/chapterEnglish2018

Publisher, publication year, extent ...

2018-02-27
Wiley,2018

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LIBRIS-ID:oai:lup.lub.lu.se:9d721213-1523-4d6d-b249-6fa9025688b8
https://lup.lub.lu.se/record/9d721213-1523-4d6d-b249-6fa9025688b8URI
https://doi.org/10.1016/j.jalz.2018.01.010DOI
https://gup.ub.gu.se/publication/265774URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

Introduction: We studied whether fully automated Elecsys cerebrospinal fluid (CSF) immunoassay results were concordant with positron emission tomography (PET) and predicted clinical progression, even with cutoffs established in an independent cohort. Methods: Cutoffs for Elecsys amyloid-β1–42 (Aβ), total tau/Aβ(1–42), and phosphorylated tau/Aβ(1–42) were defined against [18F]flutemetamol PET in Swedish BioFINDER (n = 277) and validated against [18F]florbetapir PET in Alzheimer's Disease Neuroimaging Initiative (n = 646). Clinical progression in patients with mild cognitive impairment (n = 619) was studied. Results: CSF total tau/Aβ(1–42) and phosphorylated tau/Aβ(1–42) ratios were highly concordant with PET classification in BioFINDER (overall percent agreement: 90%; area under the curve: 94%). The CSF biomarker statuses established by predefined cutoffs were highly concordant with PET classification in Alzheimer's Disease Neuroimaging Initiative (overall percent agreement: 89%–90%; area under the curves: 96%) and predicted greater 2-year clinical decline in patients with mild cognitive impairment. Strikingly, tau/Aβ ratios were as accurate as semiquantitative PET image assessment in predicting visual read–based outcomes. Discussion: Elecsys CSF biomarker assays may provide reliable alternatives to PET in Alzheimer's disease diagnosis.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Amyloid PET concordance
Amyloid-β (1–42)
Biomarker validation
Clinical progression
CSF biomarkers
Cutoffs
Phosphorylated tau (pTau)
Total tau (tTau)

Added entries (persons, corporate bodies, meetings, titles ...)

Seibyl, JohnInstitute For Neurodegenerative Disorders (author)
Stomrud, ErikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-esr (author)
Zetterberg, HenrikGothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,University College London,UK Dementia Research Institute,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
Trojanowski, John Q.University of Pennsylvania (author)
Bittner, TobiasRoche Diagnostics, Germany (author)
Lifke, ValeriaRoche Diagnostics, Germany (author)
Corradini, VeronikaRoche Diagnostics International (author)
Eichenlaub, UdoRoche Diagnostics, Germany (author)
Batrla, RichardRoche Diagnostics International (author)
Buck, KatharinaRoche Diagnostics, Germany (author)
Zink, KatharinaRoche Diagnostics, Germany (author)
Rabe, ChristinaRoche Diagnostics, Germany (author)
Blennow, KajGothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
Shaw, Leslie M.University of Pennsylvania (author)
Klinisk minnesforskningForskargrupper vid Lunds universitet (creator_code:org_t)
Swedish BioFINDER study group
Alzheimer's Disease Neuroimaging Initiative

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In:Alzheimer's and Dementia: Wiley14:11, s. 1470-14811552-52601552-5279

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By the author/editor: Hansson, Oskar; Seibyl, John; Stomrud, Erik; Zetterberg, Henr ...; Trojanowski, Joh ...; Bittner, Tobias; show more...; Lifke, Valeria; Corradini, Veron ...; Eichenlaub, Udo; Batrla, Richard; Buck, Katharina; Zink, Katharina; Rabe, Christina; Blennow, Kaj; Shaw, Leslie M.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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By the university: Lund University; University of Gothenburg

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