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Clinical characteri...
Clinical characteristics and outcomes of patients with Hodgkin lymphoma with central nervous system involvement : An international multicenter collaboration
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- Cheah, Chan Y. (author)
- University of Texas,University of Western Australia, Crawley
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- Bröckelmann, Paul J. (author)
- Memorial Sloan-Kettering Cancer Center
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- Chihara, Dai (author)
- University of Texas
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- Moskowitz, Alison J. (author)
- Memorial Sloan-Kettering Cancer Center
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- Engert, Andreas (author)
- University Hospital of Cologne
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- Jerkeman, Mats (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- El-Galaly, Tarec C. (author)
- Aalborg University Hospital
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- Augustson, Bradley (author)
- University of Western Australia, Crawley
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- Vose, Julie (author)
- University of Nebraska Medical Center
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- Bartlett, Nancy L. (author)
- Washington University in St. Louis
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- Villa, Diego (author)
- British Columbia Cancer Agency
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- Connors, Joseph M. (author)
- British Columbia Cancer Agency
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- Feldman, Tatyana (author)
- Hackensack University Medical Center
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- Pinnix, Chelsea C. (author)
- University of Texas
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- Milgrom, Sarah A. (author)
- University of Texas
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- Dabaja, Bouthaina (author)
- University of Texas
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- Oki, Yasuhiro (author)
- University of Texas
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- Fanale, Michelle A. (author)
- University of Texas
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(creator_code:org_t)
- 2016-06-20
- 2016
- English 6 s.
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In: American Journal of Hematology. - : Wiley. - 0361-8609. ; 91:9, s. 894-899
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Abstract
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- Central nervous system (CNS) involvement is rare in patients with Hodgkin lymphoma (HL). Thus, the clinical features and outcomes are not well described. Cases of histologically confirmed CNS HL diagnosed between 1995 and 2015 were retrospectively identified in institutional (n = 7), national (n = 2), and cooperative group (n = 1) databases. We screened 30,781 patients with HL in our combined databases and identified 21 patients meeting eligibility criteria, an estimated frequency of 0.07%. CNS involvement was present at initial diagnosis in 10 patients (48%) and a feature of relapsed/refractory disease in 11 (52%). Among these 11 patients, the median time from initial diagnosis of HL to development of CNS involvement was 1.9 years (range 0.4–6.6) and the median number of prior lines of therapy was 2 (range 1–7). Altogether, treatments included radiation, multiagent systemic chemotherapy, combined modality therapy, and subtotal resection. The overall response rate was 65%. After a median follow-up of 3.6 years (range 0.8–13.2) from diagnosis of CNS HL, the median PFS and OS were 7.6 and 29 months, respectively. CNS involvement as a feature of relapsed/refractory disease was adversely prognostic for both PFS and OS; however, four patients remain alive and free of relapse at 7–78 months follow-up. CNS involvement in HL is exceedingly rare and has a distinct clinical presentation with predilection for parenchymal lesions with dural extension. Around one-quarter of patients, mostly with CNS involvement at initial HL diagnosis, experience prolonged disease-free survival. Am. J. Hematol. 91:894–899, 2016.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- By the author/editor
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Cheah, Chan Y.
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Bröckelmann, Pau ...
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Chihara, Dai
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Moskowitz, Aliso ...
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Engert, Andreas
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Jerkeman, Mats
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show more...
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El-Galaly, Tarec ...
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Augustson, Bradl ...
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Vose, Julie
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Bartlett, Nancy ...
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Villa, Diego
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Connors, Joseph ...
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Feldman, Tatyana
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Pinnix, Chelsea ...
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Milgrom, Sarah A ...
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Dabaja, Bouthain ...
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Oki, Yasuhiro
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Fanale, Michelle ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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American Journal ...
- By the university
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Lund University