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  • Bendtsen, Katja MariaThe National Research Centre for the Working Environment (author)

Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-08-08
  • Springer Science and Business Media LLC,2020

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:9e420b8c-e1fe-4981-a752-d132c78b95ce
  • https://lup.lub.lu.se/record/9e420b8c-e1fe-4981-a752-d132c78b95ceURI
  • https://doi.org/10.1186/s12989-020-00369-9DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • BACKGROUND: Diesel exhaust is carcinogenic and exposure to diesel particles cause health effects. We investigated the toxicity of diesel exhaust particles designed to have varying physicochemical properties in order to attribute health effects to specific particle characteristics. Particles from three fuel types were compared at 13% engine intake O2 concentration: MK1 ultra low sulfur diesel (DEP13) and the two renewable diesel fuels hydrotreated vegetable oil (HVO13) and rapeseed methyl ester (RME13). Additionally, diesel particles from MK1 ultra low sulfur diesel were generated at 9.7% (DEP9.7) and 17% (DEP17) intake O2 concentration. We evaluated physicochemical properties and histopathological, inflammatory and genotoxic responses on day 1, 28, and 90 after single intratracheal instillation in mice compared to reference diesel particles and carbon black. RESULTS: Moderate variations were seen in physical properties for the five particles: primary particle diameter: 15-22 nm, specific surface area: 152-222 m2/g, and count median mobility diameter: 55-103 nm. Larger differences were found in chemical composition: organic carbon/total carbon ratio (0.12-0.60), polycyclic aromatic hydrocarbon content (1-27 μg/mg) and acid-extractable metal content (0.9-16 μg/mg). Intratracheal exposure to all five particles induced similar toxicological responses, with different potency. Lung particle retention was observed in DEP13 and HVO13 exposed mice on day 28 post-exposure, with less retention for the other fuel types. RME exposure induced limited response whereas the remaining particles induced dose-dependent inflammation and acute phase response on day 1. DEP13 induced acute phase response on day 28 and inflammation on day 90. DNA strand break levels were not increased as compared to vehicle, but were increased in lung and liver compared to blank filter extraction control. Neutrophil influx on day 1 correlated best with estimated deposited surface area, but also with elemental carbon, organic carbon and PAHs. DNA strand break levels in lung on day 28 and in liver on day 90 correlated with acellular particle-induced ROS. CONCLUSIONS: We studied diesel exhaust particles designed to differ in physicochemical properties. Our study highlights specific surface area, elemental carbon content, PAHs and ROS-generating potential as physicochemical predictors of diesel particle toxicity.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Gren, LouiseLund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)educ-leg (author)
  • Malmborg, Vilhelm BergLund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)desi-vhb (author)
  • Shukla, Pravesh ChandraLund University,Lunds universitet,Förbränningsmotorer,Institutionen för energivetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Combustion Engines,Department of Energy Sciences,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)pr6303sh (author)
  • Tunér, MartinLund University,Lunds universitet,Förbränningsmotorer,Institutionen för energivetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Combustion Engines,Department of Energy Sciences,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)forb-mtu (author)
  • Essig, Yona J. (author)
  • Krais, Annette M.Lund University,Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups(Swepub:lu)med-ak5 (author)
  • Clausen, Per AxelThe National Research Centre for the Working Environment (author)
  • Berthing, TrineThe National Research Centre for the Working Environment (author)
  • Loeschner, KatrinTechnical University of Denmark (author)
  • Jacobsen, Nicklas RaunThe National Research Centre for the Working Environment (author)
  • Wolff, HenrikFinnish Institute of Occupational Health (author)
  • Pagels, JoakimLund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)ie-jpa (author)
  • Vogel, Ulla BirgitteTechnical University of Denmark,The National Research Centre for the Working Environment (author)
  • The National Research Centre for the Working EnvironmentNanoLund: Centre for Nanoscience (creator_code:org_t)

Related titles

  • In:Particle and Fibre Toxicology: Springer Science and Business Media LLC17:11743-8977

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