Prolonged labour associated with lower expression of syndecan 3 and connexin 43 in human uterine tissue

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Cluff, AH (author)

Prolonged labour associated with lower expression of syndecan 3 and connexin 43 in human uterine tissue

Article/chapterEnglish2006

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2006-05-04
Springer Science and Business Media LLC,2006

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LIBRIS-ID:oai:lup.lub.lu.se:9e77d100-ffa9-4ff5-960a-8a24c2a7f702
https://lup.lub.lu.se/record/405830URI
https://doi.org/10.1186/1477-7827-4-24DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:1940121URI

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Language:English
Summary in:English

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Background: Prolonged labour is associated with greater morbidity and mortality for mother and child. Connexin 43 is a major myometrial gap junction protein found in human myometrium. Syndecan 3 seems to prevail in the human uterus among heparan sulphate proteoglycans, showing the most significant increase during labour. The aims of the present study were to investigate syndecan 3 and connexin 43 mRNA expressions and protein distributions in human uterine tissue during normal and prolonged labour. Methods: Uterine isthmic biopsies were collected from non-pregnant (n = 7), term pregnant women not in labour (n = 14), in normal labour (n = 7) and in prolonged labour (n = 7). mRNA levels of syndecan 3 and connexin 43 were determined by real time RT-PCR. The localization and expression were demonstrated by immunohistochemistry and confocal microscopy. Results: In women with prolonged labour, the mRNA expressions of syndecan 3 and Connexin 43 were considerably lower than the expression level at normal labour (p < 0.05). In term-pregnant tissue, the expression of syndecan 3 and connexin 43 did not differ significantly compared to nonpregnant and normal labour. The immunoreactivity of syndecan 3 was strong at normal labour, in contrast to prolonged labour, where both a weaker expression and an irregular distribution were detected. The immunoreactivity of connexin 43 increased until term and further stronger staining occurred at normal labour. At prolonged labour, the immunoreactivity was weaker and more unevenly distributed. At labour, a co-localization of syndecan 3 and connexin 43 could be demonstrated in the smooth muscle by confocal microscopy. Conclusion: The high expression of syndecan 3 and connexin 43 and their co-localization to the smooth muscle bundles during normal labour, together with the significant reduction in prolonged labour, may indicate a role for these proteins in the co-ordination of myometrial contractility.

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Bystrom, BKarolinska Institutet (author)
Klimaviciute, AKarolinska Institutet (author)
Dahlqvist, CamillaLund University,Lunds universitet,Matrixbiologi,Forskargrupper vid Lunds universitet,Matrix Biology,Lund University Research Groups(Swepub:lu)medk-cda (author)
Cebers, G (author)
Malmström, AndersLund University,Lunds universitet,Matrixbiologi,Forskargrupper vid Lunds universitet,Matrix Biology,Lund University Research Groups(Swepub:lu)medk-ama (author)
Ekman-Ordeberg, GKarolinska Institutet (author)
Karolinska InstitutetMatrixbiologi (creator_code:org_t)

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In:Reproductive Biology and Endocrinology: Springer Science and Business Media LLC41477-7827

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

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By the university: Lund University; Karolinska Institutet

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