Search: id:"swepub:oai:lup.lub.lu.se:9edcc2ce-64ad-4947-8ef6-d62ef1d64673" >
Paradoxical role of...
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Cebrián, María José GarcíaUppsala University Hospital
(author)
Paradoxical role of hmgb1 in pancreatic cancer : Tumor suppressor or tumor promoter?
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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Anticancer Research USA Inc.2016
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10 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:9edcc2ce-64ad-4947-8ef6-d62ef1d64673
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https://lup.lub.lu.se/record/9edcc2ce-64ad-4947-8ef6-d62ef1d64673URI
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https://doi.org/10.21873/anticanres.10981DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:for swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Pancreatic cancer has a dismal prognosis and there is an increasing and unmet need to identify better diagnostic and therapeutic targets in order to ameliorate the course of the disease. HMGB1, a nuclear DNA-binding protein that acts as a transcription factor, is currently in the limelight. HMGB1 exhibits a dual role in pancreatic cancer; when intracellular, it acts as an anti-tumor protein stabilizing the genome, whereas extracellular HMGB1 behaves as a protumor protein with cytokine, chemokine and growth factor functions. Although the exact mechanisms of HMGB1 in pancreatic cancer are still to be elucidated, the significance of this protein for processes, such as autophagy, immunogenic cell death, tumor growth, metastasis and resistance to chemotherapy, have become increasingly clear. In this review, we provide a systematic summary and review of the biological and clinical relevance of HMGB1 in pancreatic cancer.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Bauden, MonikaLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lever-, pankreas- och gallvägskirurgi,Forskargrupper vid Lunds universitet,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Hepato-Pancreato-Biliary Surgery,Lund University Research Groups(Swepub:lu)med-mnb
(author)
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Andersson, RolandLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lever-, pankreas- och gallvägskirurgi,Forskargrupper vid Lunds universitet,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Hepato-Pancreato-Biliary Surgery,Lund University Research Groups(Swepub:lu)kir-ran
(author)
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Holdenrieder, StefanTechnical University of Munich
(author)
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Ansari, DanielLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lever-, pankreas- och gallvägskirurgi,Forskargrupper vid Lunds universitet,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Hepato-Pancreato-Biliary Surgery,Lund University Research Groups(Swepub:lu)med-dar
(author)
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Uppsala University HospitalKirurgi, Lund
(creator_code:org_t)
Related titles
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In:Anticancer research: Anticancer Research USA Inc.36:9, s. 4381-43900250-7005
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