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- Landin-Olsson, MLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diabetes lab,Forskargrupper vid Lunds universitet,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital (författare)
Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children
- Artikel/kapitelEngelska1992
Förlag, utgivningsår, omfång ...
- 1992
Nummerbeteckningar
- LIBRIS-ID:oai:lup.lub.lu.se:9ef41b7e-6d7b-408c-a814-9c701fb63bf8
- https://lup.lub.lu.se/record/9ef41b7e-6d7b-408c-a814-9c701fb63bf8URI
- https://doi.org/10.1007/BF02221683DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Most studies evaluating immune markers for prediction of Type 1 (insulin-dependent) diabetes mellitus have focused on first degree relatives, although only 10% of newly-diagnosed patients have an affected first degree relative. The Swedish Childhood Diabetes Register identifies 99% of all diabetic children at diagnosis. In this population-based study, islet cell antibodies and insulin autoantibodies in 0-14-year-old Swedish consecutively-diagnosed patients and control subjects were analysed to define their sensitivity and specificity. Over 16 months (1986-1987), 515 Swedish children developed diabetes. Plasma samples were obtained from 494 (96%) patients, and 420 matched control children. Among patients, the frequency of islet cell antibodies was 84% (415 of 494), insulin autoantibodies 43% (145 of 334); 40% (135 of 334) were positive for both and 88% (294 of 334) were positive for one or both. Among control children, 3% (14 of 420) had islet cell antibodies, 1% (4 of 390) insulin autoantibodies, and 4% (16 of 390) had either autoantibody marker. The predictive value of finding a patient with the disease was only 7% since 4% of the control children were antibody-positive and the cumulative incidence rate up to 15 years of age is 0.38%. None of the autoantibody-positive (n = 21) or negative control children developed diabetes during 3 to 5 years of follow-up. Longitudinal investigations of islet cell or insulin-autoantibody-positive healthy children are necessary to accurately determine the conversion rate from marker positivity to disease onset.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
- Adolescent
- Autoantibodies/analysis
- Biomarkers/analysis
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1/diagnosis
- Follow-Up Studies
- Humans
- Incidence
- Infant
- Insulin Antibodies/analysis
- Islets of Langerhans/immunology
- Longitudinal Studies
- Population
- Predictive Value of Tests
- Sweden/epidemiology
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Palmer, J P (författare)
- Lernmark, AUniversity of Washington, Seattle(Swepub:lu)endo-ale (författare)
- Blom, LUmeå University(Swepub:lu)pedi-lbl (författare)
- Sundkvist, GLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)endo-gsu (författare)
- Nyström, LKarolinska Institutet (författare)
- Dahlquist, GUmeå University (författare)
- Medicin, LundSektion II (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Diabetologia35:11, s. 73-10680012-186X
Internetlänk
Hitta mer i SwePub
- Av författaren/redakt...
- Landin-Olsson, M
- Palmer, J P
- Lernmark, A
- Blom, L
- Sundkvist, G
- Nyström, L
- visa fler...
- Dahlquist, G
- visa färre...
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- Diabetologia
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- Lunds universitet
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