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Measures of Physica...
Measures of Physical Performance and Muscle Strength as Predictors of Fracture Risk Independent of FRAX, Falls, and aBMD : A Meta-Analysis Of The Osteoporotic Fractures In Men (MrOS) Study
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- Harvey, Nicholas C. (author)
- Univ Southampton, Lifecourse Epidemiol Unit, MRC, Southampton, Hants, England;Univ Southampton, Southampton Biomed Res Ctr, NIHR, Southampton, Hants, England;Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England,University of Southampton,University Hospital Southampton,University of Oxford
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- Oden, Anders (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska Academy,University of Sheffield,Centre for Bone and Arthritis Research
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- Orwoll, Eric (author)
- Oregon Hlth & Sci Univ, Portland, OR 97201 USA,Oregon Health & Science University
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- Lapidus, Jodi (author)
- Oregon Hlth & Sci Univ, Div Biostat, Dept Publ Hlth & Prevent Med, Portland, OR 97201 USA,Oregon Health & Science University
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- Kwok, Timothy (author)
- Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China;Chinese Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China,Chinese University of Hong Kong
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- Karlsson, Magnus K. (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital
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- Rosengren, Björn E. (author)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital
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- Ribom, Eva L (author)
- Uppsala University,Uppsala universitet,Ortopedi
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- Cooper, Cyrus (author)
- Univ Southampton, Lifecourse Epidemiol Unit, MRC, Southampton, Hants, England;Univ Southampton, Southampton Biomed Res Ctr, NIHR, Southampton, Hants, England;Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England;Univ Oxford, Biomed Res Ctr, NIHR, Oxford, England
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- Cawthon, Peggy M. (author)
- Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA,California Pacific Medical Center,University of California System
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- Kanis, John A. (author)
- Univ Sheffield, Ctr Metab Bone Dis, Sheffield, S Yorkshire, England;Catholic Univ Australia, Inst Hlth & Aging, Melbourne, Vic, Australia,University of Sheffield,Australian Catholic University
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Mellström, Dan, 1945 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Johansson, Helena, 1981 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,University of Sheffield,Australian Catholic University,Centre for Bone and Arthritis Research
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- McCloskey, Eugene (author)
- Univ Sheffield, Ctr Metab Bone Dis, Sheffield, S Yorkshire, England;Univ Sheffield, Ctr Integrated Res Musculoskeletal Ageing CIMA, Mellanby Ctr Bone Res, Sheffield, S Yorkshire, England,University of Sheffield
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(creator_code:org_t)
- 2018-08-29
- 2018
- English.
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In: Journal of Bone and Mineral Research. - : Wiley. - 0884-0431 .- 1523-4681. ; 33:12, s. 2150-2157
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Abstract
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- Measures of muscle mass, strength, and function predict risk of incident fractures, but it is not known whether this risk information is additive to that from FRAX (fracture risk assessment tool) probability. In the Osteoporotic Fractures in Men (MrOS) Study cohorts (Sweden, Hong Kong, United States), we investigated whether measures of physical performance/appendicular lean mass (ALM) by DXA predicted incident fractures in older men, independently of FRAX probability. Baseline information included falls history, clinical risk factors for falls and fractures, femoral neck aBMD, and calculated FRAX probabilities. An extension of Poisson regression was used to investigate the relationship between time for five chair stands, walking speed over a 6 m distance, grip strength, ALM adjusted for body size (ALM/height(2)), FRAX probability (major osteoporotic fracture [MOF]) with or without femoral neck aBMD, available in a subset of n = 7531), and incident MOF (hip, clinical vertebral, wrist, or proximal humerus). Associations were adjusted for age and time since baseline, and are reported as hazard ratios (HRs) for first incident fracture per SD increment in predictor using meta-analysis. 5660 men in the United States (mean age 73.5 years), 2764 men in Sweden (75.4 years), and 1987 men in Hong Kong (72.4 years) were studied. Mean follow-up time was 8.7 to 10.9 years. Greater time for five chair stands was associated with greater risk of MOF (HR 1.26; 95% CI, 1.19 to 1.34), whereas greater walking speed (HR 0.85; 95% CI, 0.79 to 0.90), grip strength (HR 0.77; 95% CI, 0.72 to 0.82), and ALM/height(2) (HR 0.85; 95% CI, 0.80 to 0.90) were associated with lower risk of incident MOF. Associations remained largely similar after adjustment for FRAX, but associations between ALM/height(2) and MOF were weakened (HR 0.92; 95% CI, 0.85 to 0.99). Inclusion of femoral neck aBMD markedly attenuated the association between ALM/height(2) and MOF (HR 1.02; 95% CI, 0.96 to 1.10). Measures of physical performance predicted incident fractures independently of FRAX probability. Whilst the predictive value of ALM/height(2) was substantially reduced by inclusion of aBMD requires further study, these findings support the consideration of physical performance in fracture risk assessment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Osteoporosis
- Epidemiology
- Frax
- Falls
- Fracture
- Interaction
- EPIDEMIOLOGY
- FALLS
- FRACTURE
- FRAX
- INTERACTION
- OSTEOPOROSIS
Publication and Content Type
- ref (subject category)
- art (subject category)
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Harvey, Nicholas ...
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Oden, Anders
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Orwoll, Eric
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Lapidus, Jodi
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Kwok, Timothy
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Karlsson, Magnus ...
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Rosengren, Björn ...
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Ribom, Eva L
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Cooper, Cyrus
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Cawthon, Peggy M ...
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Kanis, John A.
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Ohlsson, Claes, ...
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Mellström, Dan, ...
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Johansson, Helen ...
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McCloskey, Eugen ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Journal of Bone ...
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Uppsala University
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Lund University
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University of Gothenburg