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Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT : An IMI DIRECT Study

Tura, Andrea (author)
CNR Istituto per le Tecnologie Applicate ai Beni Culturali (CNR-ITABC),CNR Inst Neurosci, Padua, Italy.
Grespan, Eleonora (author)
CNR Istituto per le Tecnologie Applicate ai Beni Culturali (CNR-ITABC)
Göbl, Christian S. (author)
Medical University of Vienna
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Koivula, Robert W. (author)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital,University of Oxford
Franks, Paul W. (author)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
Pearson, Ewan R. (author)
University of Dundee
Walker, Mark (author)
University of Newcastle upon Tyne
Forgie, Ian M. (author)
University of Dundee
Giordano, Giuseppe N. (author)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
Pavo, Imre (author)
Eli Lilly Regional Operations G.m.b.H.
Ruetten, Hartmut (author)
Boehringer Ingelheim GmbH
Dermitzakis, Emmanouil T. (author)
University of Geneva Medical School
McCarthy, Mark I. (author)
University of Oxford
Pedersen, Oluf (author)
University of Copenhagen
Schwenk, Jochen M. (author)
KTH,KTH Royal Institute of Technology,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
Adamski, Jerzy (author)
University of Ljubljana,National University of Singapore,Helmholtz Zentrum München
De Masi, Federico (author)
Technical University of Denmark,University of Copenhagen
Tsirigos, Konstantinos D. (author)
University of Copenhagen,Technical University of Denmark
Brunak, Søren (author)
Technical University of Denmark,University of Copenhagen
Viñuela, Ana (author)
University of Geneva Medical School,University of Newcastle upon Tyne
Mahajan, Anubha (author)
Wellcome Trust Centre for Human Genetics
McDonald, Timothy J. (author)
Royal Devon and Exeter NHS Foundation Trust
Kokkola, Tarja (author)
University of Eastern Finland
Vangipurapu, Jagadish (author)
University of Eastern Finland
Cederberg, Henna (author)
University of Eastern Finland
Laakso, Markku (author)
University of Eastern Finland
Rutters, Femke (author)
Amsterdam UMC - Vrije Universiteit Amsterdam
Elders, Petra J.M. (author)
Amsterdam UMC - Vrije Universiteit Amsterdam
Koopman, Anitra D.M. (author)
Amsterdam UMC - Vrije Universiteit Amsterdam
Beulens, Joline W. (author)
Amsterdam UMC - Vrije Universiteit Amsterdam
Ridderstråle, Martin (author)
Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
Hansen, Tue H. (author)
University of Copenhagen
Allin, Kristine H. (author)
University of Copenhagen
Hansen, Torben (author)
University of Copenhagen
Vestergaard, Henrik (author)
University of Copenhagen,Bornholms Hospital
Mari, Andrea (author)
CNR Institute of Neuroscience, Pisa,CNR Inst Neurosci, Padua, Italy.
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CNR Istituto per le Tecnologie Applicate ai Beni Culturali (CNR-ITABC) CNR Inst Neurosci, Padua, Italy (creator_code:org_t)
 
2021-07-07
2021
English 15 s.
In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 70:9, s. 2092-2106
Related links:
http://dx.doi.org/10... (free)
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https://diabetes.dia...
https://doi.org/10.2...
https://lup.lub.lu.s...
https://doi.org/10.2...
https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or HbA1c indicative of prediabetes [IA1c]), two defects (IFG+IGT, IFG+IA1c, or IGT+IA1c), or all defects (IFG+IGT+IA1c). β-Cell function (BCF) and insulin sensitivity were assessed from OGTT. At baseline, in pooling of participants with isolated defects, they showed impairment in both BCF and insulin sensitivity compared with healthy control subjects. Pooled groups with two or three defects showed progressive further deterioration. Among groups with isolated defect, those with IGT showed lower insulin sensitivity, insulin secretion at reference glucose (ISRr), and insulin secretion potentiation (P < 0.002). Conversely, those with IA1c showed higher insulin sensitivity and ISRr (P < 0.0001). Among groups with two defects, we similarly found differences in both BCF and insulin sensitivity. At 48 months, we found higher type 2 diabetes incidence for progressively increasing number of prediabetes defects (odds ratio >2, P < 0.008). In conclusion, the prediabetes groups showed differences in type/degree of glucometabolic impairment. Compared with the pooled group with isolated defects, those with double or triple defect showed progressive differences in diabetes incidence.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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art (subject category)
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