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  • Steffen, Annika (author)

Meat and Heme Iron Intake and Risk of Squamous Cell Carcinoma of the Upper Aero-Digestive Tract in the European Prospective Investigation into Cancer and Nutrition (EPIC)

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • 2012

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:9f4405a3-f31e-4c66-90ec-5097a5d8cd54
  • https://lup.lub.lu.se/record/3367885URI
  • https://doi.org/10.1158/1055-9965.EPI-12-0835DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-64048URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Evidence from prospective studies on intake of meat and fish and risk of squamous cell carcinoma (SCC) of the upper aero-digestive tract (UADT) is scarce. We prospectively investigated the association of meat and fish intake with risk of SCC of the UADT and the possible mechanism via heme iron in the large multicenter European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: Multivariable proportional hazards models were used to estimate relative risks (RR) of SCC of the UADT in relation to intake of total meat, as well as subtypes of meat, fish, and heme iron among 348,738 individuals from 7 European countries. Results: During an average follow-up of 11.8 years, a total of 682 incident cases of UADT SCC were accrued. Intake of processed meat was positively associated with risk of SCC of the UADT in the total cohort (highest vs. lowest quintile: RR = 1.41; 95% confidence interval (CI) = 1.03-1.941, however, in stratified analyses, this association was confined to the group of current smokers (highest vs. lowest quintile: RR = 1.89; 95% CI = 1.22-2.93). Red meat, poultry, fish, and heme iron were not consistently related to UADT SCC. Conclusion: Higher intake of processed meat was positively associated with KC of the UADT among smokers. Although this finding was stable in various sensitivity analyses, we cannot rule out residual confounding by smoking. Confirmation in future studies and identification of biologic mechanisms is warranted. Impact: Smokers may further increase their risk for SCC of the UADT if they additionally consume large amounts of processed meat. Cancer Epidemiol Biomarkers Prev; 21(12); 2738-48. (C)2012 AACR.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Bergmann, Manuela M. (author)
  • Sanchez, Maria-Jose (author)
  • Chirlaque, Maria-Dolores (author)
  • Jakszyn, Paula (author)
  • Amiano, Pilar (author)
  • Ramon Quiros, J. (author)
  • Barricarte Gurrea, Aurelio (author)
  • Ferrari, Pietro (author)
  • Romieu, Isabelle (author)
  • Fedirko, Veronika (author)
  • Bueno-de-Mesquita, H. B(as) (author)
  • Siersema, Peter D. (author)
  • Peeters, Petra H. M. (author)
  • Khaw, Kay-Tee (author)
  • Wareham, Nick (author)
  • Allen, Naomi E. (author)
  • Crowe, Francesca L. (author)
  • Skeie, Guri (author)
  • Hallmanns, GöranUmeå universitet,Näringsforskning(Swepub:umu)goha0001 (author)
  • Johansson, IngegerdUmeå universitet,Institutionen för odontologi(Swepub:umu)injo0003 (author)
  • Borgquist, SigneLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)ront-sbo (author)
  • Ericson, UlrikaLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)medf-upe (author)
  • Egeberg, Rikke (author)
  • Tjonneland, Anne (author)
  • Overvad, Kim (author)
  • Grote, Verena (author)
  • Li, Kuanrong (author)
  • Trichopoulou, Antonia (author)
  • Oikonomidou, Despoina (author)
  • Pantzalis, Menelaos (author)
  • Tumino, Rosario (author)
  • Panico, Salvatore (author)
  • Palli, Domenico (author)
  • Krogh, Vittorio (author)
  • Naccarati, Alessio (author)
  • Mouw, Traci (author)
  • Vergnaud, Anne-Claire (author)
  • Norat, Teresa (author)
  • Boeing, Heiner (author)
  • Umeå universitetNäringsforskning (creator_code:org_t)

Related titles

  • In:Cancer Epidemiology Biomarkers & Prevention21:12, s. 2138-21481538-77551055-9965

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