Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

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Bellenguez, Celine (author)

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

Article/chapterEnglish2012

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2012-02-05
Springer Science and Business Media LLC,2012

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LIBRIS-ID:oai:lup.lub.lu.se:9f4ca94e-282a-49a3-98de-890883b7ea45
https://lup.lub.lu.se/record/2379201URI
https://doi.org/10.1038/ng.1081DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 x 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Bevan, Steve (author)
Gschwendtner, Andreas (author)
Spencer, Chris C. A. (author)
Burgess, Annette I. (author)
Pirinen, Matti (author)
Jackson, Caroline A. (author)
Traylor, Matthew (author)
Strange, Amy (author)
Su, Zhan (author)
Band, Gavin (author)
Syme, Paul D. (author)
Malik, Rainer (author)
Pera, Joanna (author)
Norrving, BoLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)neur-bno (author)
Lemmens, Robin (author)
Freeman, Colin (author)
Schanz, Renata (author)
James, Tom (author)
Poole, Deborah (author)
Murphy, Lee (author)
Segal, Helen (author)
Cortellini, Lynelle (author)
Cheng, Yu-Ching (author)
Woo, Daniel (author)
Nalls, Michael A. (author)
Mueller-Myhsok, Bertram (author)
Meisinger, Christa (author)
Seedorf, Udo (author)
Ross-Adams, Helen (author)
Boonen, Steven (author)
Wloch-Kopec, Dorota (author)
Valant, Valerie (author)
Slark, Julia (author)
Furie, Karen (author)
Delavaran, HosseinLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-hmh (author)
Langford, Cordelia (author)
Deloukas, Panos (author)
Edkins, Sarah (author)
Hunt, Sarah (author)
Gray, Emma (author)
Dronov, Serge (author)
Peltonen, Leena (author)
Gretarsdottir, Solveig (author)
Thorleifsson, Gudmar (author)
Thorsteinsdottir, Unnur (author)
Stefansson, Kari (author)
Boncoraglio, Giorgio B. (author)
Parati, Eugenio A. (author)
Attia, John (author)
Holliday, Elizabeth (author)
Levi, Chris (author)
Franzosi, Maria-Grazia (author)
Goel, Anuj (author)
Helgadottir, Anna (author)
Blackwell, Jenefer M. (author)
Bramon, Elvira (author)
Brown, Matthew A. (author)
Casas, Juan P. (author)
Corvin, Aiden (author)
Duncanson, Audrey (author)
Jankowski, Janusz (author)
Mathew, Christopher G. (author)
Palmer, Colin N. A. (author)
Plomin, Robert (author)
Rautanen, Anna (author)
Sawcer, Stephen J. (author)
Trembath, Richard C. (author)
Viswanathan, Ananth C. (author)
Wood, Nicholas W. (author)
Worrall, Bradford B. (author)
Kittner, Steven J. (author)
Mitchell, Braxton D. (author)
Kissela, Brett (author)
Meschia, James F. (author)
Thijs, Vincent (author)
Lindgren, ArneLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)neur-ali (author)
Macleod, Mary Joan (author)
Slowik, Agnieszka (author)
Walters, Matthew (author)
Rosand, Jonathan (author)
Sharma, Pankaj (author)
Farrall, Martin (author)
Sudlow, Cathie L. M. (author)
Rothwell, Peter M. (author)
Dichgans, Martin (author)
Donnelly, Peter (author)
Markus, Hugh S. (author)
Neurologi, LundSektion IV (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC44:3, s. 141-3281546-17181061-4036

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By the author/editor: Bellenguez, Celi ...; Bevan, Steve; Gschwendtner, An ...; Spencer, Chris C ...; Burgess, Annette ...; Pirinen, Matti; show more...; Jackson, Carolin ...; Traylor, Matthew; Strange, Amy; Su, Zhan; Band, Gavin; Syme, Paul D.; Malik, Rainer; Pera, Joanna; Norrving, Bo; Lemmens, Robin; Freeman, Colin; Schanz, Renata; James, Tom; Poole, Deborah; Murphy, Lee; Segal, Helen; Cortellini, Lyne ...; Cheng, Yu-Ching; Woo, Daniel; Nalls, Michael A ...; Mueller-Myhsok, ...; Meisinger, Chris ...; Seedorf, Udo; Ross-Adams, Hele ...; Boonen, Steven; Wloch-Kopec, Dor ...; Valant, Valerie; Slark, Julia; Furie, Karen; Delavaran, Hosse ...; Langford, Cordel ...; Deloukas, Panos; Edkins, Sarah; Hunt, Sarah; Gray, Emma; Dronov, Serge; Peltonen, Leena; Gretarsdottir, S ...; Thorleifsson, Gu ...; Thorsteinsdottir ...; Stefansson, Kari; Boncoraglio, Gio ...; Parati, Eugenio ...; Attia, John; Holliday, Elizab ...; Levi, Chris; Franzosi, Maria- ...; Goel, Anuj; Helgadottir, Ann ...; Blackwell, Jenef ...; Bramon, Elvira; Brown, Matthew A ...; Casas, Juan P.; Corvin, Aiden; Duncanson, Audre ...; Jankowski, Janus ...; Mathew, Christop ...; Palmer, Colin N. ...; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen ...; Trembath, Richar ...; Viswanathan, Ana ...; Wood, Nicholas W ...; Worrall, Bradfor ...; Kittner, Steven ...; Mitchell, Braxto ...; Kissela, Brett; Meschia, James F ...; Thijs, Vincent; Lindgren, Arne; Macleod, Mary Jo ...; Slowik, Agnieszk ...; Walters, Matthew; Rosand, Jonathan; Sharma, Pankaj; Farrall, Martin; Sudlow, Cathie L ...; Rothwell, Peter ...; Dichgans, Martin; Donnelly, Peter; Markus, Hugh S.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

Articles in the publication: Nature Genetics

By the university: Lund University

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