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Sökning: id:"swepub:oai:lup.lub.lu.se:9f8025b2-ea67-476e-abb4-651f3c5fcd5d" > Patients with Lemie...

  • Valerio, LucaUniversitätsmedizin Mainz (författare)

Patients with Lemierre syndrome have a high risk of new thromboembolic complications, clinical sequelae and death : an analysis of 712 cases

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2020-06-18
  • Wiley,2021

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:9f8025b2-ea67-476e-abb4-651f3c5fcd5d
  • https://lup.lub.lu.se/record/9f8025b2-ea67-476e-abb4-651f3c5fcd5dURI
  • https://doi.org/10.1111/joim.13114DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background: Lemierre syndrome is characterized by head/neck vein thrombosis and septic embolism usually complicating an acute oropharyngeal bacterial infection in adolescents and young adults. We described the course of Lemierre syndrome in the contemporary era. Methods: In our individual-level analysis of 712 patients (2000–2017), we included cases described as Lemierre syndrome if these criteria were met: (i) primary site of bacterial infection in the head/neck; (ii) objectively confirmed local thrombotic complications or septic embolism. The study outcomes were new or recurrent venous thromboembolism or peripheral septic lesions, major bleeding, all-cause death and clinical sequelae. Results: The median age was 21 (Q1–Q3: 17–33) years, and 295 (41%) were female. At diagnosis, acute thrombosis of head/neck veins was detected in 597 (84%) patients, septic embolism in 582 (82%) and both in 468 (80%). After diagnosis and during in-hospital follow-up, new venous thromboembolism occurred in 34 (5.2%, 95% CI 3.8–7.2%) patients, new peripheral septic lesions became evident in 76 (11.7%; 9.4–14.3%). The rate of either was lower in patients who received anticoagulation (OR: 0.59; 0.36–0.94), higher in those with initial intracranial involvement (OR: 2.35; 1.45–3.80). Major bleeding occurred in 19 patients (2.9%; 1.9–4.5%), and 26 died (4.0%; 2.7–5.8%). Clinical sequelae were reported in 65 (10.4%, 8.2–13.0%) individuals, often consisting of cranial nerve palsy (n = 24) and orthopaedic limitations (n = 19). Conclusions: Patients with Lemierre syndrome were characterized by a substantial risk of new thromboembolic complications and death. This risk was higher in the presence of initial intracranial involvement. One-tenth of survivors suffered major clinical sequelae.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Zane, FedericaHospital of Sondrio (författare)
  • Sacco, ClaraHumanitas Research Hospital (författare)
  • Granziera, Serena (författare)
  • Nicoletti, TommasoPoliclinico Universitario Agostino Gemelli (författare)
  • Russo, MariaconcettaUniversitätsmedizin Mainz (författare)
  • Corsi, GabrieleFatebenefratelli Hospital (författare)
  • Holm, KarinLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Translationell infektionsmedicin,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Translational infection medicine,Lund University Research Groups(Swepub:lu)med-khm (författare)
  • Hotz, Michel AndréUniversity of Bern (författare)
  • Righini, ChristianGrenoble University Hospital (författare)
  • Karkos, Petros D.Aristotle University of Thessaloniki (författare)
  • Mahmoudpour, Seyed HamidrezaUniversitätsmedizin Mainz(Swepub:lu)se8521ha (författare)
  • Kucher, NilsUniversity Hospital of Zurich (författare)
  • Verhamme, PeterUniversity Hospitals Leuven (författare)
  • Di Nisio, MarcelloUniversity G.d'Annunzio of Chieti-Pescara (författare)
  • Centor, Robert M. (författare)
  • Konstantinides, Stavros V.Democritus University of Thrace,Universitätsmedizin Mainz (författare)
  • Pecci, AlessandroPoliclinico San Matteo Pavia Fondazione (författare)
  • Barco, StefanoUniversitätsmedizin Mainz,University Hospital of Zurich (författare)
  • Universitätsmedizin MainzHospital of Sondrio (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Internal Medicine: Wiley289:3, s. 325-3390954-68201365-2796

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