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Patients with Lemie...
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Valerio, LucaUniversitätsmedizin Mainz
(författare)
Patients with Lemierre syndrome have a high risk of new thromboembolic complications, clinical sequelae and death : an analysis of 712 cases
- Artikel/kapitelEngelska2021
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:9f8025b2-ea67-476e-abb4-651f3c5fcd5d
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https://lup.lub.lu.se/record/9f8025b2-ea67-476e-abb4-651f3c5fcd5dURI
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https://doi.org/10.1111/joim.13114DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Background: Lemierre syndrome is characterized by head/neck vein thrombosis and septic embolism usually complicating an acute oropharyngeal bacterial infection in adolescents and young adults. We described the course of Lemierre syndrome in the contemporary era. Methods: In our individual-level analysis of 712 patients (2000–2017), we included cases described as Lemierre syndrome if these criteria were met: (i) primary site of bacterial infection in the head/neck; (ii) objectively confirmed local thrombotic complications or septic embolism. The study outcomes were new or recurrent venous thromboembolism or peripheral septic lesions, major bleeding, all-cause death and clinical sequelae. Results: The median age was 21 (Q1–Q3: 17–33) years, and 295 (41%) were female. At diagnosis, acute thrombosis of head/neck veins was detected in 597 (84%) patients, septic embolism in 582 (82%) and both in 468 (80%). After diagnosis and during in-hospital follow-up, new venous thromboembolism occurred in 34 (5.2%, 95% CI 3.8–7.2%) patients, new peripheral septic lesions became evident in 76 (11.7%; 9.4–14.3%). The rate of either was lower in patients who received anticoagulation (OR: 0.59; 0.36–0.94), higher in those with initial intracranial involvement (OR: 2.35; 1.45–3.80). Major bleeding occurred in 19 patients (2.9%; 1.9–4.5%), and 26 died (4.0%; 2.7–5.8%). Clinical sequelae were reported in 65 (10.4%, 8.2–13.0%) individuals, often consisting of cranial nerve palsy (n = 24) and orthopaedic limitations (n = 19). Conclusions: Patients with Lemierre syndrome were characterized by a substantial risk of new thromboembolic complications and death. This risk was higher in the presence of initial intracranial involvement. One-tenth of survivors suffered major clinical sequelae.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Zane, FedericaHospital of Sondrio
(författare)
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Sacco, ClaraHumanitas Research Hospital
(författare)
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Granziera, Serena
(författare)
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Nicoletti, TommasoPoliclinico Universitario Agostino Gemelli
(författare)
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Russo, MariaconcettaUniversitätsmedizin Mainz
(författare)
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Corsi, GabrieleFatebenefratelli Hospital
(författare)
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Holm, KarinLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Translationell infektionsmedicin,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Translational infection medicine,Lund University Research Groups(Swepub:lu)med-khm
(författare)
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Hotz, Michel AndréUniversity of Bern
(författare)
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Righini, ChristianGrenoble University Hospital
(författare)
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Karkos, Petros D.Aristotle University of Thessaloniki
(författare)
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Mahmoudpour, Seyed HamidrezaUniversitätsmedizin Mainz(Swepub:lu)se8521ha
(författare)
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Kucher, NilsUniversity Hospital of Zurich
(författare)
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Verhamme, PeterUniversity Hospitals Leuven
(författare)
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Di Nisio, MarcelloUniversity G.d'Annunzio of Chieti-Pescara
(författare)
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Centor, Robert M.
(författare)
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Konstantinides, Stavros V.Democritus University of Thrace,Universitätsmedizin Mainz
(författare)
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Pecci, AlessandroPoliclinico San Matteo Pavia Fondazione
(författare)
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Barco, StefanoUniversitätsmedizin Mainz,University Hospital of Zurich
(författare)
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Universitätsmedizin MainzHospital of Sondrio
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Internal Medicine: Wiley289:3, s. 325-3390954-68201365-2796
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Valerio, Luca
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Zane, Federica
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Sacco, Clara
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Granziera, Seren ...
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Nicoletti, Tomma ...
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Russo, Mariaconc ...
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visa fler...
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Corsi, Gabriele
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Holm, Karin
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Hotz, Michel And ...
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Righini, Christi ...
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Karkos, Petros D ...
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Mahmoudpour, Sey ...
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Kucher, Nils
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Verhamme, Peter
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Di Nisio, Marcel ...
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Centor, Robert M ...
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Konstantinides, ...
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Pecci, Alessandr ...
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Barco, Stefano
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Journal of Inter ...
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Lunds universitet