Search: id:"swepub:oai:lup.lub.lu.se:9f8e3d59-64dd-4d59-8379-f7913373c203" >
Obstructive sleep a...
-
Strausz, SatuHelsinki University Central Hospital,University of Helsinki,Finnish National Institute for Health and Welfare
(author)
Obstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes : A longitudinal population-based study in Finland
- Article/chapterEnglish2018
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:9f8e3d59-64dd-4d59-8379-f7913373c203
-
https://lup.lub.lu.se/record/9f8e3d59-64dd-4d59-8379-f7913373c203URI
-
https://doi.org/10.1136/bmjopen-2018-022752DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:139963628URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Objective To evaluate if obstructive sleep apnoea (OSA) modifies the risk of coronary heart disease, type 2 diabetes (T2D) and diabetic complications in a gender-specific fashion. Design and setting A longitudinal population-based study with up to 25-year follow-up data on 36 963 individuals (>500 000 person years) from three population-based cohorts: the FINRISK study, the Health 2000 Cohort Study and the Botnia Study. Main outcome measures Incident coronary heart disease, diabetic kidney disease, T2D and all-cause mortality from the Finnish National Hospital Discharge Register and the Finnish National Causes-of-Death Register. Results After adjustments for age, sex, region, high-density lipoprotein (HDL) and total cholesterol, current cigarette smoking, body mass index, hypertension, T2D baseline and family history of stroke or myocardial infarction, OSA increased the risk for coronary heart disease (HR=1.36, p=0.0014, 95% CI 1.12 to 1.64), particularly in women (HR=2.01, 95% CI 1.31 to 3.07, p=0.0012). T2D clustered with OSA independently of obesity (HR=1.48, 95% CI 1.26 to 1.73, p=9.11× 10 7). The risk of diabetic kidney disease increased 1.75-fold in patients with OSA (95% CI 1.13 to 2.71, p=0.013). OSA increased the risk for coronary heart disease similarly among patients with T2D and in general population (HR=1.36). All-cause mortality was increased by OSA in diabetic individuals (HR=1.35, 95% CI 1.06 to 1.71, p=0.016). Conclusion OSA is an independent risk factor for coronary heart disease, T2D and diabetic kidney disease. This effect is more pronounced even in women, who until now have received less attention in diagnosis and treatment of OSA than men.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Havulinna, Aki S.Finnish National Institute for Health and Welfare,University of Helsinki
(author)
-
Tuomi, TiinamaijaUniversity of Helsinki,Helsinki University Central Hospital,Folkhälsan Research Center(Swepub:lu)ti8736tu
(author)
-
Bachour, AdelHelsinki University Central Hospital
(author)
-
Groop, LeifLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki(Swepub:lu)endo-lgr
(author)
-
Mäkitie, AnttiKarolinska Institutet,Helsinki University Central Hospital,University of Helsinki
(author)
-
Koskinen, SeppoFinnish National Institute for Health and Welfare
(author)
-
Salomaa, VeikkoFinnish National Institute for Health and Welfare
(author)
-
Palotie, AarnoUniversity of Helsinki,Broad Institute,Massachusetts General Hospital(Swepub:lu)med-aop
(author)
-
Ripatti, SamuliUniversity of Helsinki(Swepub:lu)med-sur
(author)
-
Palotie, TuulaHelsinki University Central Hospital,University of Helsinki
(author)
-
Helsinki University Central HospitalUniversity of Helsinki
(creator_code:org_t)
Related titles
-
In:BMJ Open: BMJ8:102044-6055
Internet link
Find in a library
-
BMJ Open
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Strausz, Satu
-
Havulinna, Aki S ...
-
Tuomi, Tiinamaij ...
-
Bachour, Adel
-
Groop, Leif
-
Mäkitie, Antti
-
show more...
-
Koskinen, Seppo
-
Salomaa, Veikko
-
Palotie, Aarno
-
Ripatti, Samuli
-
Palotie, Tuula
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Respiratory Medi ...
- Articles in the publication
-
BMJ Open
- By the university
-
Lund University
-
Karolinska Institutet